
Places to stay near Biosphere 2
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Top-rated vacation rentals near Biosphere 2
Guests agree: these stays are highly rated for location, cleanliness, and more.

Luxury Home In Catalina Foothills Tucson
Stunning Modern Home in Catalina Foothills This beautifully remodeled home sits on a spacious one-acre lot in the highly sought-after Catalina Foothills. Featuring 3 master suites, each with brand-new bathrooms, walking showers, and double vanities, this home effortlessly blends comfort and modern design. Ideally located, you’re just minutes from shopping, fine dining, and a 10–15 minute drive to downtown, University Ave, and 4th Avenue. Space, style, and location--all in one stunning package!

The Zendo Oasis. Your Private Resort in Tucson.
Discover the Zendo Oasis, your private resort in midtown Tucson. Don't settle for a sterile hotel room that can cost hundreds more. The Zendo offers a retreat atmosphere that will impress. Exercise in our full gym and luxuriate in a hot stone sauna! After, jump in the pool! Sip wine while enjoying evenings around a chiminea under starlit skies. Lounge by the pool in the sun or shade on the deck or under louvered patios. The Zendo is close to the UA and downtown. Book now and escape the ordinary!

Hilltop Home with Amazing views to entire Tucson
Rejuvenate in the only home in the neighborhood what provides undisrupted views to Cathalina mountains and the entire city of Tucson! This home offers sustainable living, with a fully indoor/outdoor connection, swimming pool, hot tub and amazing privacy! The light, airy home features open-plan living and over sized windows to maximize the breathtaking views. Enjoy drinks on the patio and a sunset. In the evening, light a fire in the outdoor fireplace and relax in a lounge chair under the stars.

The Cottage @ Sanctuary Cove, 80 acres of serenity
A secluded getaway, Sanctuary Cove's Guest Cottage is surrounded by 80 acres of pristine Southwest Desert. Stewarded by a religious non-profit, Sanctuary Cove is a place of respite from the happenings of modern life. The property has hiking trails, easy access to less explored areas of Saguaro National Park, a non-denominational chapel for prayer and meditation, an amphitheater overlooking the Tucson Valley, and a traditional labyrinth. For more information, visit the Sanctuary Cove website.

West-side Trailhead Retreat in the Sonoran Desert
2017 guest house in Tucson Mountain foothills adjacent to Sweetwater Preserve (14+ mi.s of trails: mountain biking, horseback, running, & hiking)! Enjoy the giant soaking tub, BBQ grill, sunsets & patio. A full kitchen, sitting area, bath & BR are downstairs (550 sq. ft.). Up a 90-degree ladder to BR/retreat space, wonderful for getaway views. Our property is a 3-acre lot w/ desert flora/fauna, stars, & quietness, yet only 10 mi. from UA. Horses add to the ambiance with a taste of ranch life.

Villa Clemente Central 1br Resort Oasis UofA Dtwn
Welcome to Villa Clemente, your peaceful desert escape in the heart of Tucson! This stylish, resort-inspired 1-bedroom retreat is perfect for solo travelers, couples, or a trio seeking comfort and convenience. Whether you're here for a campus visit, golf weekend, hiking adventure, or a restful staycation, Villa Clemente offers everything you need to relax and recharge. 1BR w/ rain shower, full kitchen, coffee bar, grill, putting green, luxe touches, near UofA, Reid Park, golf & hiking trails.

A Secluded Retreat in Nature - La Casita
La Casita is nestled on 2.3 secluded acres next to the Coronado National Forest. The comfortable vintage cottage has good light and sweeping views of the foothills and woodlands around it. A beautiful garden and various outdoor sitting areas provide relaxing places to enjoy the quiet nature and many birds that live there. The Oracle Ridge trailhead to Mt. Lemmon is just a 5-minute walk from the house. These features and more are what make your stay at La Casita so enjoyable and special.

Cozy Mountain Retreat w/ Hot Tub
Come visit our small horse ranch in NW Tucson! Tucked into the foothills of the Santa Catalina Mountains, you’ll enjoy great views, and slightly cooler temperatures. You'll be close enough to town to have access restaurants,shopping, entertainment, etc, yet you'll have unlimited access to hiking and mountain biking right out our gate. * Not suitable for children under 12yrs. **This is a smoke-free property, sorry, no exceptions. *you must be able to climb a small flight of stairs*

Attractive Casita In Tucson
A charming getaway casita with stunning views of the majestic Saguaro National Park and the Picture Rock Mountains for spectacular sunsets. The 5-acre site is home to many varieties of cacti, including giant saguaros and other native plants and trees. Through the casita's panoramic windows, you can observe desert vegetation, birds, rabbits, coyotes, bobcats, javelinas, and deer. An evening bath in the jacuzzi under the starry sky will certainly remain in your memory for a long time.

Forest Hermitage With Creek. Close To Everything!
Imagine waking up to the sounds of birds chirping and the trickling of water from the creek as you sip your favorite hot drink from the balcony among the pine and fir trees. This cabin is just a stone's throw away from town center with a food shop right across the street, but is a true mountain hermitage where you can unplug and unwind from all your concerns. And with fast Wifi, you can do your best work remotely amidst the serenity of nature while a fresh mountain breeze blows.

Tucson Poet's Studio
Tucson Poet's Studio was featured in Architectural Digest (10-1-2025) “50 Best Airbnbs Across the United States", New York Magazine (6-19-2015) “Taste the Flavors of Tucson” and LivAbility (7-6-2018) “Accessible Airbnb” *NEW* EV Charger! The studio shares the private, walled courtyard and pool with the main house where my husband and I live. Located in the Peter Howell neighborhood, a convenient midtown area close to everything (2.5 mi to UA, 5 mi to downtown).

Modern Loft w/ Pool & Hot Tub-Views!
Stargaze, admire the incredible mountain views & wildlife at this 2 story gated loft! Enjoy the pool table, above ground pool, hot tub, new appliances/bathroom, grill, Smart TVs, and games! Minutes away from popular hikes, 8 mins from Agua Caliente Park, 12 mins from Saguaro National Park, 15 mins from Sabino Canyon, 55 mins from Mount Lemon (a must visit!). The loft has a lot of character and is set up for only 4 guests! No parties, smoking, or gatherings.
Popular amenities for vacation rentals near Biosphere 2
Condo rentals with wifi

Upstairs Corner Casita w/ incredible sunset views.

1st Floor Casita Greens At Ventana Canyon 85750

Cozy studio UNIT 3, WHITE DOOR

The Sunrise Suite, a luxury 1 bed condo

Catalina Foothills Getaway

Gorgeous Mountain & City Views, Pools, & Hot Tubs

Tasteful, Modern Luxury. Great Location.

Luxury Ventana Canyon Condo!
Family-friendly house rentals

Lux Million Dollar Views Gem in the Mountains

Indoor/outdoor desert retreat

INDOOR Pool , AMAZING Views, Game Room, Gym & more

Hacienda Riad: free pool heat, hot tub, views

Santa Fe style 3 bedroom home with private pool

Stunning Southwest Style Vacation Home

Exclusive La Cholla Luxury House

Views-GameRoom-Comfy Beds-Pool-Hiking@Saguaro West
Apartment rentals with air conditioning

The Saguaro Suite-SW Retreat w/Private Entrance

Prime Location, 3 Pool Areas, Fitness Center, More

Casita Linda: one minute walk to the U of A

Downtown Historic Adobe

Unique, Vintage Studio Apartment near U of A

Jungle Escape • King Bed • Walk Downtown & U of A

Midtown pied-à-terre: Agua Linda Suite

Saguaro Retreat
Other great vacation rentals near Biosphere 2

Peaceful Desert Oasis in Central Tucson Foothills

Tucson Mountain Retreat

Avra Ranchette, artist retreat & naturalist dream

Mountain View Casita

The Tucson Bungalow | Designer Sam Hughes Retreat

Rural hilltop gem, 360 views

Catalina Foothills West Red Suite Rooftop Patio

Giant Saguaros | Casita | 15 min to Downtown
Destinations to explore
- Saguaro National Park
- Mount Lemmon
- Mt Lemmon Ski Valley
- University of Arizona
- University of Arizona
- Sabino Canyon
- Arizona-Sonora Desert Museum
- Tumamoc Hill
- Tucson Botanical Gardens
- Sabino Canyon Recreation Area
- Reid Park Zoo
- Catalina State Park
- Titan Missile Museum
- Mission San Xavier del Bac
- Tucson Museum of Art
- Pima Air & Space Museum
- Tucson Convention Center
- Rialto Theatre
- Children's Museum Tucson
- Picacho Peak State Park
- Mini Time Machine Museum of Miniatures
- Casa Grande Ruins National Monument
- Trail Dust Town
- Roy P Drachman - Agua Caliente Regional Park





