Vacation rentals in Cape Girardeau County

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Top-rated vacation rentals in Cape Girardeau County

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favourite
Guest suite in Cape Girardeau
MAINSTAY CAPE [downtown]
Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.
Jun. 5 – 12
$122 CAD per night
4.96 out of 5 average rating, 103 reviews
Guest favourite
Apartment in Cape Girardeau
Brand new 2 bedroom unit right in downtown Cape.
This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .
Jan. 13 – 20
$184 CAD per night
4.94 out of 5 average rating, 163 reviews
Guest favourite
Apartment in Cape Girardeau
Unique Design | Walk Downtown/River | .5 mile SEMO
At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.
Sep. 29 – Oct. 6
$140 CAD per night
4.85 out of 5 average rating, 525 reviews

Popular amenities for Cape Girardeau County vacation rentals

Other great vacation rentals in Cape Girardeau County

Guest favourite
Home in Jackson
The Rusty Owl-A Charming Victorian Dwelling
Apr. 22 – 29
$159 CAD per night
4.92 out of 5 average rating, 260 reviews
Guest favourite
Apartment in Cape Girardeau
Beautiful Historic Boulevard District Apartment
Aug. 31 – Sep. 7
$154 CAD per night
4.97 out of 5 average rating, 339 reviews
Guest favourite
Cottage in Cape Girardeau
Historic Cottage Walkable to Downtown Cape
Jun. 13 – 20
$260 CAD per night
4.98 out of 5 average rating, 170 reviews
Guest favourite
Home in Cape Girardeau
The Hamilton House
Aug. 15 – 22
$158 CAD per night
4.98 out of 5 average rating, 343 reviews
Guest favourite
Home in Cape Girardeau
River Run
Oct. 18 – 25
$361 CAD per night
4.97 out of 5 average rating, 116 reviews
Guest favourite
Treehouse in Cape Girardeau
Twisted Sassafras Treehouse
Feb. 3 – 10
$403 CAD per night
4.98 out of 5 average rating, 48 reviews
Guest favourite
Guesthouse in Cape Girardeau
Cozy 1-BR guest house w/free parking on premises
Apr. 29 – May 6
$115 CAD per night
4.94 out of 5 average rating, 51 reviews
Guest favourite
Barn in Cape Girardeau
Under the Stars - Farmhouse
Aug. 18 – 25
$317 CAD per night
4.95 out of 5 average rating, 92 reviews
Guest favourite
Home in Cape Girardeau
House Of Clubs- 2 Bed 1.5 Bath
Nov. 18 – 25
$217 CAD per night
4.95 out of 5 average rating, 62 reviews
Guest favourite
Cottage in Cape Girardeau
Country cottage with view of winding creek
Jul. 24 – 31
$195 CAD per night
4.9 out of 5 average rating, 72 reviews
Guest favourite
Apartment in Cape Girardeau
Private Downtown Apartment
Oct. 4 – 11
$184 CAD per night
4.97 out of 5 average rating, 58 reviews
Guest favourite
Apartment in Cape Girardeau
Historical Kage House
Sep. 9 – 16
$231 CAD per night
4.97 out of 5 average rating, 70 reviews

Destinations to explore