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Vacation rentals in Doña Ana

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Top-rated vacation rentals in Doña Ana

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favourite
Guesthouse in Las Cruces
4.95 out of 5 average rating, 196 reviews

Quaint casita for 2

*Sep 2025 New bed/Aug 2024 New A/C mini split* Quiet cul-de-sac and peaceful landing spot within minutes to NMSU and Old Mesilla. Easy access to I-10 and I-25. Close to golf courses, shopping and the beauty of Las Cruces and Mesilla. Private entrance to casita, patio with dining table and a cozy bedroom, bathroom with tub/shower, WiFi, coffee station, refrigerator with small freezer, microwave. Wonderful hiking trails nearby and less than 60 minutes to White Sands National Park and ELP Airport.

Top guest favourite
An aerial view of a Pueblo Style home is presented, showcasing a serene pool surrounded by a spacious outdoor area. The home is set against a backdrop of rolling hills and a cloudy sky. Desert vegetation is seen throughout the landscape, enhancing the natural beauty.
Home in Las Cruces
4.98 out of 5 average rating, 144 reviews

Desert Oasis with Pool

Pueblo Style home on 1+ Acre with Pool! This charming 4BR/2BA Pueblo Style home features stunning details throughout. Gorgeous saltillo tile in the living areas with beautiful wood beam accents, and a kiva-style fireplace for cozy winter nights. The primary suite offers direct access to the covered patio for summer dips in the pool and evening Sunsets. The 4th bedroom is huge and could be used as a second living area. The pool is not heated but will be open and cleaned all year. Sorry no pets.

Top guest favourite
The living area features an open layout with a spacious couch, accent chairs, and a decorative coffee table on a colorful area rug. A television is positioned against a light wall, with artwork depicting floral designs hung above. Natural light enters through various windows.
Home in Las Cruces
4.99 out of 5 average rating, 123 reviews

Bonita Casita

This is a centrally located, remodeled 2 bedroom, 2 bathroom townhouse, very convenient to HWY 70, a straight shot to White Sands National Park, and Main Street, easy access to Downtown Las Cruces, home to Las Cruces's Farmer's Market. This townhouse features a split and open floor plan, full kitchen with everything you need to prepare a meal, dishwasher, microwave and gas cooking. You will also find an office and outdoor seating area. The property is located very near the lovely 4-Hills Park.

Top guest favourite
An outdoor seating area is highlighted by four Adirondack chairs arranged around a glowing gas fire pit. A stone wall forms the background, while a dining set is visible in the distance, with soft evening light creating a serene atmosphere.
Home in Las Cruces
4.96 out of 5 average rating, 132 reviews

Luxury Southwest Retreat

Our home provides comfort, relaxation, and convenience in an invitingly decorated setting. Three rooms offer various sleeping arrangements to meet all of your needs. Choose from a king, queen, or twin beds. Fully equipped and thoughtfully appointed kitchen provides for all of your meal needs. Luxurious backyard with Adirondack chairs, gas fire pit, porch rocking chairs, and outdoor dining set allow for relaxing and socializing. Washer & dryer available, detergent and fabric softener provided.

Guest favourite
The exterior of a Southwestern home is showcased, featuring adobe-style architecture with a textured beige facade. A two-car garage is visible, along with a gravel front yard and desert landscaping, highlighted by rocks and sparse vegetation under a clear blue sky.
Home in Las Cruces
4.87 out of 5 average rating, 309 reviews

Casa Miranda, The Organ Mountains Looking House

Experience your clean, comfortable & spacious Southwestern home in Las Cruces, NM, now with a brand new refrigerated AC system. Your home has wonderful amenities: a fully stocked kitchen, washer/dryer, iron, comfortable beds (king & queen size), 65' flat screen TV in the living room with Wifi, secure two car garage, and a backyard with a breathtaking view of The Organ Mountains. Located minutes from both I-25/ US-70, easily get to downtown, Mesilla, NMSU, White Sands, and The Lincoln Forest.

Superhost
A cozy living room is depicted, featuring a comfortable dark sofa with decorative cushions. A large piece of wall art displays two figures sitting on a bench, creating a sense of connection. An antique trunk and a decorative green vase enhance the inviting space.
Earth homes in Las Cruces
4.84 out of 5 average rating, 610 reviews

Southwest Mexican Adobe Casa Historic District

This wonderful adobe home with refrigerated air is located directly in the heart of the city the Mesquite Historic District of Las Cruces. This Mexican home combines the neighborhood classic adobe style. Directly across the street is a Mexican cafe and a coffee shop. Seven minute walk to downtown which has wonderful pubs and restaurants. This home is located directly across the street from my other two casitas that are listed in Airbnb. Dog fee $10.00 which can be left on the table.

Top guest favourite
A vibrant yellow casita is framed by a rocky landscape and native vegetation. Large windows and a covered porch are visible, inviting natural light. The casita's exterior showcases a blend of rustic charm and modern design, set against a clear blue sky.
Guesthouse in Las Cruces
4.98 out of 5 average rating, 147 reviews

Raven's House

Casita De Cuervo is a beautiful detached casita. This spacious & quiet casita is very close to popular hiking trails and feels remote while being less than 15 minutes from I-25, NMSU, and both hospitals. This home has a full kitchen, king bed, open living room, work nook, bar stool dining, & much more. Dogs are welcome - there is an enclosed side yard with tall walls for your use. Enjoy the sunrise over the Organ Mountains on the back porch and breathtaking sunset views over the city.

Superhost
The image captures a clear salt-water pool with sparkling turquoise water under a bright blue sky. Sunlight reflects off the surface, while a yellow flowering tree and lounging chairs are visible in the background, creating a serene outdoor space.
Shipping container in Las Cruces
4.91 out of 5 average rating, 1,050 reviews

Nature Retreat 12-min from Downtown (with pool)

Re-purposed 40-foot shipping container w/Ikea cabinets & furniture at edge of desert. Loft is 1 of 2 dwellings on 5-acre lot, private exterior doors & adjacent reserved parking. Picture window with wonderful view of Organ Mountains. Compact kitchen, Serta PillowTop queen size bed, full bathroom, LED lighting, cooled/heated by modern heat pump, Wi-Fi Internet. Pool access in season (usually April-October). Hike/bike from doorstep. Pet-friendly, see House Rules for details/cost.

Top guest favourite
The entrance features a traditional adobe archway with purple wooden doors flanked by a rustic ladder. A lantern hangs above the opening, while desert vegetation is visible to one side. The backdrop includes distant mountains under a clear blue sky.
Guesthouse in Las Cruces
5 out of 5 average rating, 268 reviews

Desert Peaks Casita

This lovingly remodeled casita just fifteen minutes from downtown Las Cruces is open, spacious, and comfortably equipped for any length stay. Take in the views of the mountains, watch the birds, or relax in the hot tub under the stars. Hike to the Organ Mountains-Desert Peaks National Monument via an arroyo from the casita, take a dip in the pool, or rest in the peaceful and tastefully decorated space. It is a perfect place for a quiet getaway or as a base to explore the area.

Guest favourite
An open living area is showcased, featuring a large sectional sofa facing a mounted television. A wooden coffee table sits in front of the sofa. The kitchen is visible, equipped with modern appliances and bar seating, while large windows provide ample natural light.
Home in Las Cruces
4.89 out of 5 average rating, 219 reviews

Modern Accessorized 3-Bedroom

This fully-furnished modern home is perfect for weekend getaways or longterm stays. With latest in appliances and style, the Powder River Villa offers the comfort of home with a luxury feel. Stream Netflix in front of the stacked stone fireplace, decompress in the pebble rain shower, or simply relax on the back porch to the beautiful New Mexico sunsets. This stylish space can be the romantic escape you're seeking or comfortably fit your group of 7.

Guest favourite
A studio space features a queen bed with soft bedding, a seating area with two armchairs, and a small kitchenette equipped with a coffee maker and microwave. Natural light enters through a window, while a stylish circular mirror hangs on the wall, enhancing the room's openness.
Guesthouse in Las Cruces
4.95 out of 5 average rating, 152 reviews

Spacious studio near Mesilla

Forget your worries in this spacious and serene space in Mesilla Park, near Historic Mesilla. Centrally located, close to I10, without the noise! Stylishly decorated with a kitchenette that has all you will need to prepare basic food. Microwave, pressure cooker, hotplate, small fridge, coffee maker, and toaster oven. Stocked kitchen to include gourmet coffee, English muffins, and farm fresh eggs for making a quick breakfast are waiting for you!

Top guest favourite
A charming casita features a turquoise door and a light exterior, framed by subtle landscaping. The sky is filled with vibrant orange and yellow hues as the sun sets, creating a striking contrast against the white walls and windows.
Guesthouse in Las Cruces
4.99 out of 5 average rating, 170 reviews

Cozy Casita De Mesilla (Mesilla Cottage)

Cozy casita just steps from Old Mesilla’s historic plaza and coffee shops. Unwind in your private courtyard with a hot tub, or curl up by the fireplace inside the guesthouse. A kitchenette adds comfort for longer stays. Mesilla Bosque State Park by the Rio Grande is only 4 minutes by car—or a short bike ride—perfect for birdwatching, sunsets, and peaceful walks. The ideal spot for a romantic getaway or quiet retreat.

Popular amenities for Doña Ana vacation rentals

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  2. United States
  3. New Mexico
  4. Doña Ana County
  5. Doña Ana