
Vacation rentals in La Mesilla
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Top-rated vacation rentals in La Mesilla
Guests agree: these stays are highly rated for location, cleanliness, and more.

Happy Ram: Views! Beautiful. Peaceful. Upscale.
Want a unique, stylish, peaceful stay in Santa Fe? Happy Ram is an architect-designed, professionally decorated home on a 6.4-acre estate. Huge views of the Sangre de Cristo mountains from every room. Thick rammed earth walls create incredible quiet. Bedrooms on opposite sides of the home for maximum privacy. Patio with fireplace. Just 5 minutes to hip Tesuque Village, 6 to Four Seasons Resort, 11 to Santa Fe Opera, 14 to Santa Fe Plaza. Make your Santa Fe dream vacation come true! STRO-40172

Desert Hideaway - Private Casita Suite
Brand new shower!! Experience the ultimate desert escape at our guest suite, nestled amidst majestic mountains. This charming oasis offers a serene retreat with a queen bed, full kitchen, bath, and dining room. Embrace the tranquility of the desert landscape as you relax in the cozy suite & savor panoramic mountain views. Immerse yourself in nature's beauty embarking on thrilling adventures. Discover the perfect balance between comfort & breathtaking surroundings in this idyllic desert haven.

100+ Reviews | All 5 Stars Rating | Private Casita
Over 100 reviews—all 5 stars—offering a consistently exceptional stay. Wake up to breathtaking Sangre de Cristo Mountain views in this cozy 350 sqft retreat. Perfect for couples or solo travelers, designed for comfort, calm, and a peaceful getaway. Our casita earned 100 perfect 5-star reviews in 12 months for its layout, serene vibe, views, and hosting. Sip coffee with mountain views, unwind in bright living space, and enjoy full privacy with a fully equipped kitchen and private entrance.

Hilltop Nest
Kick back and relax in this stylish cabin in the forest. Hilltop location with forever views. Just off scenic Route 66 (Hwy 50), up a steep (but short) driveway, sits a 2-bedroom log cabin with plenty of birdsong and pine trees, a porch surrounded by views and furnished with a grill for outdoor dining. Five miles east is the village of Pecos with the Pecos River for fishing, hiking, and exploring. Sixteen miles north is the legendary city of Santa Fe packed with world-class art and culture

The Barn - Tiny Home near Santa Fe & Los Alamos
About 30 minutes from Santa Fe, experience this awesome tiny home themed "The Barn"! The custom bathroom features a stock tank bathtub and sink that you can tell all of your friends and family about! The kitchen is furnished with a refrigerator/freezer, oven/stove, microwave, toaster, coffee pot and more. With a queen bed in the main space and a twin bed in the loft, The Barn can sleep up to 3 people. The home also has a smart TV and Wifi so you can enjoy your stay or catch up on work.

Stylish cottage in a beautiful canyon on the river
We welcome guests of all races, faiths, genders, sexual orientations, and countries of origin. Over a bridge and steps from the Embudo River, this stylish, well-equipped cottage is nestled under cottonwood trees in a private canyon facing a stunning rock face. Relax on the deck overlooking the water, and during late spring and early summer, listen to the river as you fall asleep. The quaint village of Dixon (an artist and vineyard, orchard, organic farm community) is just a mile away.

Cozy Forest Escape with Private Hot Tub
Escape to a Peaceful Forest Retreat Nestled on a 1.5-acre wooded lot, this relaxing cabin offers the perfect retreat for nature lovers and adventure seekers. Located adjacent to the Valles Caldera National Preserve, our property boasts: - Relaxing Hot Tub: Unwind among the pines - Wildlife watching opportunities - Short drive to Fenton Lake for top-notch fishing - Modern comforts for a peaceful stay - Proximity to outdoor activities for all seasons: hiking, biking, fishing, and skiing

Studio in Santa Fe
Located 7 miles north of Santa Fe Plaza, this country retreat, is in the Village of Tesuque, one mile from Tesuque Village Market, El Nido Restaurant and Glenn Greene Galleries, five miles to the Santa Fe Opera, and 7 miles to the Santa Fe Plaza. Enjoy your own studio apartment with outdoor patio, private parking , in a peaceful country setting. Tesuque is central to many New Mexico experiences - visit nearby pueblos, state parks and monuments, casinos, rafting and hiking trails.

Top 1% | River Oasis | Hot Springs Nearby
Nestled at the base of a majestic mountain, Casa del Rio offers sweeping views of the mesa and river, with the Jemez River flowing right through the property. Modern amenities meet natural beauty—enjoy sunsets from the deck, s’mores by the riverside firepit, and drift off to the soothing sounds of the water. Just five minutes from hot springs and scenic hikes, and only an hour from Santa Fe or Albuquerque, it’s the perfect place to relax, explore, and make unforgettable memories.

Charming Camper near Santa Fe
Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.

Beautiful View
Nambé, New Mexico in Santa Fe County quiet rural setting. It is located 20 minutes from Historic Santa Fe, surrounded by Ancient Anasazi hiking trails and ruins. On the High Road to Taos. Enjoy the peace of the country. Safe and friendly. Romantic, comfortable ,within a private compound. All the amenities of home. Star filled nights, quaint, beautiful accommodations and a charming shared garden to relax and enjoy the beauty of the view of the Sangre de Cristo Mountains.

Guest House in Espanola
This unique place has a style all its own. It is an adorable adobe casita with its own full bath, King bed, mini fridge, microwave and coffee maker. Located in the beautiful Espanola Valley, just 45 miles away from Taos, 25 miles away from Santa Fe and 17 miles away from Los Alamos.The Casita is located near local restaurants and shopping areas but is hidden in its own private beautiful neighborhood.
Popular amenities for La Mesilla vacation rentals
Other great vacation rentals in La Mesilla

El Conejo - Santa Fe Casita

Earthship in Taos: A Sustainable Desert Sanctuary

Lake Abiquiu Pedernal Retreat!

Refined Adobe w/Mountain Views, Hot Tub & Fire Pit

Casita de Chuparosa

La Bonita Ermita

The Green House

Abiquiu Adobe with Private Canyon O'Keeffe Country
Destinations to explore
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- Ski Santa Fe
- Meow Wolf
- Sipapu Ski & Summer Resort
- Santa Fe Plaza
- Georgia O'Keeffe Museum
- Museum of International Folk Art
- Bandelier National Monument
- Taos Plaza
- Santa Fe Farmers Market
- Santa Fe National Forest
- El Santuario De Chimayo
- Rio Grande Gorge Bridge
- Loretto Chapel
- The Cathedral Basilica Of St. Francis Of Assisi
- Pecos National Historical Park




