
Vacation rentals in Orangeburg County
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Top-rated vacation rentals in Orangeburg County
Guests agree: these stays are highly rated for location, cleanliness, and more.

Theo's Place
Kick back and relax in this calm, stylish space. I'm happy to offer my 1st home as a host, providing all the amenities I've wanted as a guest in my years of successful stays on the AirBnB platform as a guest (laptop not included). My guest will find various comforts and additions to make their stay as comfortable as can be. I welcome your feedback. My home is available as a 1 Bedroom with a large Den, Living & Dining rooms, 2 Bathrooms, full Kitchen and Laundry room. All new appliances as well.

Mulberry Cabin, a rustic tiny house cabin
Mulberry Cabin is conveniently located halfway between Charleston and the capital city of Columbia in Rowesville, SC. Please note the cabin is located in a small town, not in the country. Rowesville is 11 minutes from the beautiful Edisto Memorial Gardens in Orangeburg. Orangeburg has many restaurants, Wal-Mart, and a Starbucks near I-26. Columbia is about an hour away. Charleston is about 75 minutes away. Enjoy a break from Wi-Fi as you watch a DVD and relax in a 130 year old rustic cabin.

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

The Grand Marshall
Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Elevated Country Apartment
Discover the charm of country-living in our cozy 1-bedroom elevated apartment, just a short drive from Orangeburg, Bamberg, and Neeses. Wake up to the sound of roosters crowing and enjoy your morning coffee with views of our picturesque homestead, or enjoy a glass of wine while watching the sun set below the majestic pines. Perfect for those seeking tranquility without sacrificing convenience, our apartment offers a fully-equipped kitchen and laundry.

Clover Cottage
Clover Cottage is a cozy place to stay if you need a quiet place to unwind. Located on Main Street, Clover Cottage is walking distance to restaurants and grocery store. The cottage is a completely renovated property which started life as the summer kitchen for the main house. The cottage is 150 years old and has maintained the charm of a historic home. To retain the history of the property and town, NO SMOKING or VAPING is allowed on the property.

Ellzey Place
Ellzey Place is a peaceful spot where you can relax and unwind. Enjoy having a cup of coffee on the deck facing a spacious private back yard. There are lots of azaleas that bloom in season and pines swaying in the breeze. It is a charming apartment attached to the owner's house but has a private deck and entrance. It has been newly remodeled and delightfully decorated.

Oak View
Enjoy having a cup of coffee relaxing in the swing on the front deck or sitting on the back deck facing the woods and watching the chickens pecking for food. Or take a stroll down the lane and inspect the muscadine/scuppernong vines and enjoy luscious grapes and figs in season. Enjoy a slice of country life on 2 1/2 acres.

Modern apartment overlooking a Historic Downtown
Relax at this peaceful and centrally-located getaway in the heart of historic Elloree, SC. Just minutes away from Santee, I95, I26, fishing and golfing, it's perfect for a quiet weekend getaway, business trip or staycation! Free electric car charging available for your convenience upon request.

Beautiful lakefront condo overlooking Lake Marion.
Beautiful condo located lakefront on Lake Marion in Santee, SC. This second floor unit has elevator or stair access. Balcony views the lake and pool just outside. This lake is popular for watersports and incredible fishing.
Popular amenities for Orangeburg County vacation rentals
Other great vacation rentals in Orangeburg County

The Fishnet

The Cottage on Jefferson

Colonial Farmhouse - 6 bedroom with a pool

10' ceilings and still cozy apt!

Lowcountry river life

Nightly 1 bedroom

Renovated Camper Farm Stay

Tiny Pond House
Destinations to explore
- Apartment rentals Orangeburg County
- Rentals with a hot tub Orangeburg County
- Condo rentals Orangeburg County
- Rentals with pools Orangeburg County
- Rentals with a washer and dryer Orangeburg County
- Rentals with a firepit Orangeburg County
- Hotel rooms Orangeburg County
- Rentals with lake access Orangeburg County
- Fitness-friendly rentals Orangeburg County
- Rentals with a fireplace Orangeburg County
- Family-friendly rentals Orangeburg County
- Rentals with a kayak Orangeburg County
- Pet-friendly rentals Orangeburg County
- Rentals with a patio Orangeburg County
- Rentals with outdoor seating Orangeburg County
- House rentals Orangeburg County
- Riverbanks Zoo and Garden
- South Carolina State House
- Congaree National Park
- Columbia Museum of Art
- Frankie's Fun Park
- South Carolina State Museum
- University of South Carolina
- Colonial Life Arena
- Williams Brice Stadium
- Columbia Metropolitan Convention Center
- Edventure
- Soda City Market
- Dreher Island State Park
- Saluda Shoals Park
- Riverfront Park
- West Columbia Riverwalk Park and Amphitheater




