Guesthouse vacation rentals in Appalachian Mountains

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Appalachian Mountains guesthouses

Family-friendly guesthouses

Top guest favourite
Guesthouse in Richfield
4.94 out of 5 average rating, 254 reviews

Peaceful weekend or extended stay, full amenities

BrianRating, 5 stars3 months ago
I had a great experience with Matt & Laura. They did a great job communicating and their property is very nice!
Guest favourite
Guesthouse in Niagara-on-the-Lake
4.92 out of 5 average rating, 313 reviews

On the Vineyard @ 1068, Niagara on the Lake

Jillian And JamesRating, 5 stars1 week ago
Place was just like photos. Had entire house to ourselves. Lots of space. Liked how we could sit outside. Lisa was available via messages and checked in during our stay to make sure everything was good. The location worked for us but some guests may prefer to be closer to Niagara on the lake. Winery opposite. Would recommend.
Top guest favourite
Guesthouse in Forestburgh
4.97 out of 5 average rating, 418 reviews

Guesthouse On 1879 Farm. Hot tub and hiking

AuroraRating, 5 stars2 weeks ago
This has become our vacation destination for the past 5 years. We love staying there so much that words can't suffice. Joe and Amy are the best hosts ever. Looking forward to next year!
Top guest favourite
Guesthouse in Charleston
5 out of 5 average rating, 105 reviews

Liz Lane Cottage- entire guesthouse

carolynRating, 5 stars2 weeks ago
This home felt fresh and clean, was thoughtfully designed for making a small home feel spacious and very comfortable (including outdoor seating). It is in a peaceful residential neighborhood just over the bridge from downtown charleston. The owner was very responsive and had lots of recommendations on how to spend our time.
Top guest favourite
Guesthouse in Lancaster
4.99 out of 5 average rating, 201 reviews

Wishing Well Guesthouse On The Lake

SaraRating, 5 stars2 weeks ago
Enjoyed our visit! Susan made us delicious cookies and cinnamon rolls!
Top guest favourite
Guesthouse in Gettysburg
4.99 out of 5 average rating, 426 reviews

The Cock and Feather Guesthouse

BrianRating, 5 stars1 week ago
Cute guest house off the Main Street. Nice layout: very private. Vintage decor is unique/nostalgic. Nice place and very reasonably priced. William was there to greet us.
Top guest favourite
Guesthouse in Corinth
5 out of 5 average rating, 143 reviews

The Guest House at Chandlery Farm

SarahRating, 5 stars1 week ago
This was my family's fourth stay at the farm and as usual it exceeded our expectations. The serenity of the beautiful environs and well appointed home makes you never want to venture out! From the Steinway Piano to everything you could reach for or need being at your fingertips is amazing. The house is beyond well appointed with the most luxurious linens, chef's kitchen, and beautiful views from every angle. My children loved interacting with the highland cows naming each of them. My dog, Bear, was in heaven galloping along the vast property. The owners Tom and Karen are LOVELY and just the kindest most accommodating hosts with incredible taste. We cannot wait to return! Thank you for more amazing memories!
Top guest favourite
Guesthouse in Knoxville
4.96 out of 5 average rating, 314 reviews

*MINUTES to DOWN TOWN *MOUNTAIN VIEWS*PETS OK*

WendyRating, 5 stars5 months ago
This was our second time staying at Jaclyns home. It's beautiful and peaceful, quiet and comfortable. She is a gracious hostess and you feel like your home. We will definitely will be back.

Guesthouses with a patio

Superhost
Guesthouse in South Webster
4.9 out of 5 average rating, 121 reviews

Beautiful Guest House

JacobRating, 5 stars1 week ago
Brandon was a great host and communicates well with his guests. The guest house is clean and very comfortable. Highly recommend!
Superhost
Guesthouse in Frenchtown
4.98 out of 5 average rating, 112 reviews

Clean and modern 1 bedroom studio pool house.

BenjaminRating, 5 stars1 month ago
Jane's pool house was perfect for what I needed...It was quiet and calm and cozy and in beautiful surroundings...It was very private. Jane is also a great host...she really went out of her way to make it feel like it was MY place to stay with a very warm welcome.
Superhost
Guesthouse in Campobello
4.97 out of 5 average rating, 116 reviews

Bungalow on a 3 acre mini farm

MichaelRating, 5 stars1 week ago
This was an excellent place to stay. It was beautiful. The smell of the air outside was amazing having lived a city for 5 years. Just absolutely gorgeous!
Superhost
Guesthouse in Clair
4.98 out of 5 average rating, 128 reviews

Guest House/Apt, private fully equipped, sleeps 4

SachaRating, 5 stars1 week ago
Great host and has a lot of amenities, felt like a well equipped home and super pet friendly
Superhost
Guesthouse in Phoenixville
4.93 out of 5 average rating, 102 reviews

private, quiet, new guest house 1 king bed

AleisterRating, 5 stars1 week ago
Ann was a great host. She answered questions fast and was very friendly. The place was just as described and the bed was incredibly comfortable. The running water from the stream could be heard from inside and it was very peaceful. There is only 1 parking spot fyi so be sure to take just one car. The only thing I would change is to have another small lamp in the downstairs (I hate overhead lights). Overall, I would definitely stay here again!
Superhost
Guesthouse in Wiarton
4.98 out of 5 average rating, 183 reviews

Bruce Peninsula Country Loft on 17

LiorRating, 5 stars1 week ago
The loft was absolutely perfect for a couple +3 yo! It was fully equipped, comfortable and full of fun things to do. Teresa and Lorne were lovely hosts and even went out of their way to help up out when we had trouble with our car. We definitely recommend the loft and hope to visit again someday ourselves.
Superhost
Guesthouse in Hanahan
4.99 out of 5 average rating, 186 reviews

The Violet Villa w/no cleaning fee

MeredithRating, 5 stars2 days ago
This was seriously the nicest Airbnb we’ve ever stayed in- and we were only there for about 10 hours. It was spotless, the bed was so comfy, there were extra thoughtful touches everywhere, and we were blown away. Such a cute area/neighborhood- literally couldn’t have asked for better anything. SO clean and so nice. We would love to come stay for a longer stay.
Superhost
Guesthouse in Toledo
4.95 out of 5 average rating, 188 reviews

Incredible Guest House Sylvania

Wesley Rating, 5 stars3 weeks ago
My wife and I loved this guest house. Lisa was very friendly indeed both in person and messaging. The location was great to visit our daughter at the University of Toledo, 5 miles away. It’s a magical place, worthy of staying longer. Wesley.

Guesthouse rentals with a washer and dryer

Top guest favourite
Guesthouse in Blue Ridge
4.99 out of 5 average rating, 148 reviews

Guesthouse w/FREE snacks & private river access

EmmaRating, 5 stars3 days ago
Annie was so kind and her place was perfect for our one night in Blue Ridge. It’s close to downtown and we loved the area.
Top guest favourite
Guesthouse in Dalton
5 out of 5 average rating, 113 reviews

Ray of Sunshine in Dalton

JoelRating, 5 stars5 days ago
This place was very roomy and nicely appointed. If you like to cook your own meals while traveling (as we do), Christy's is perfect with a large butcher-block island and a truly fully equipped kitchen. We thoroughly enjoyed our stay and had zero issues during our 3 days, therefore there was no need to reach out to Christy. Instructions she provided was very clear and we appreciated the safety minded reminder not to back out of the street as it does get busy with high vehicle speeds. Even though the place is off a busy street, we heard no traffic noise since the place is set back and behind the garage. If you're in Dalton, GA this is the place to stay.
Guest favourite
Guesthouse in St. Ignace
4.93 out of 5 average rating, 398 reviews

Lola's Retreat, near ferry to Mackinac Island

StephanieRating, 5 stars3 weeks ago
Very cozy quiet place!! Clean and had everything we needed. Felt like home and will be back!! Thank you so much!!
Guest favourite
Guesthouse in Newnan
4.92 out of 5 average rating, 203 reviews

Quiet Guest House

CarlRating, 5 stars4 months ago
Wonderful quiet clean place to stay. Convenient location. Has everything you need and more. Very responsive host. Have stayed here previously and already booked for another stay.
Guest favourite
Guesthouse in North Cape May
4.93 out of 5 average rating, 129 reviews

Cape Cottage

DoreenRating, 5 stars8 months ago
First time visit to Cape May for my daughter and I. We had privacy, we’re able to sleep in, see the local area and do our laundry on site. Kristie was very responsive!!!!
Guest favourite
Guesthouse in Oak Hill
4.98 out of 5 average rating, 128 reviews

Carriage House on Main near NRG National Park

DarrylRating, 5 stars3 weeks ago
Amy's West Virginia Airbnb was fantastic! The spacious, clean house was well-equipped and comfortable, with a great location near many beautiful sights. Amy was an exceptional host, providing excellent communication and helpful tips. Highly recommended for a wonderful stay!
Guest favourite
Guesthouse in Athens
4.96 out of 5 average rating, 116 reviews

Private Guest House

MarcRating, 5 stars6 months ago
Great place, easy to locate. Was close Athens! Beds were comfortable, shower were hot and nice pressure. We stayed 2 nights and it was just a place to rest my heads! We stayed inside only a few hours and that was just for sleep. It meet all our requirements and was better than expected.
Top guest favourite
Guesthouse in Burdett
4.99 out of 5 average rating, 148 reviews

Kline's Cottage

SamanthaRating, 5 stars2 days ago
The cottage was adorable with all the amenities you could need. Mallory was a great host and her family was very friendly when interacting with. I felt very much at home.

Destinations to explore