Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favourite
Guesthouse in High Hill
5 out of 5 average rating, 36 reviews

Farm Stay+Eclectic Vintage+EV Charge+Fresh Eggs

Our eclectic guesthouse is set on 80 acres of quiet magic, come unplug. Discover fun details in the art-filled interior, 1960s phone booth, and light-filled space boasting vintage finds and plants galore. Collect fresh eggs for breakfast, enjoy coffee on the expansive porch. Wander the flower and vegetable garden, hike the wooded trail, explore the creek & shower under the stars. Slow down, reconnect, recharge. 7mins off I-70, 30mins to Hermann & 50mins to both STL airport and Columbia.

Guest favourite
A historic home sits amidst lush greenery, featuring a welcoming porch with white railings. The facade showcases a combination of brick and siding, framed by tree branches, with sunlight filtering through, creating a bright and inviting atmosphere.
Home in Augusta
4.92 out of 5 average rating, 113 reviews

Honey Ridge Hideaway- Historic Home with Vineyard

Explore Augusta while staying at our historic home set on 7 acre private Vineyard. Honey Ridge Hideaway is located up on a hill overlooking the Missouri River. Our home is walking distance to downtown Augusta. Some town favorites are the farm to table restaurant, wineries, carriage rides, spa and antique shopping. Augusta also offers a local trolley to help navigate your wineries tours. This gorgeous home comfortably sleeps 10 offering the amenities of a hotel with the comfort & privacy of home.

Top guest favourite
A charming farmhouse is framed by lush green trees, displaying a welcoming front porch. The exterior showcases a muted gray siding with white accents, while a well-maintained lawn surrounds the home, enhancing the sense of tranquility in this rural setting.
Home in Augusta
4.99 out of 5 average rating, 275 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Top guest favourite
A private hot tub is illuminated with soft blue lights, surrounded by a wooden fence. String lights hang overhead, enhancing the evening ambiance. The area offers seating options, creating a cozy space for relaxation.
Cottage in Augusta
4.9 out of 5 average rating, 116 reviews

Romantic Augusta Cottage-Relax & get away!

This cottage is designed to strengthen and refresh couples looking for a getaway from busy life. Relax in the comfortable Living room or prepare a meal in the recently updated fully furnished kitchen. Enjoy your nights in the spacious bedroom furnished with a California King sized bed and TV in the room. Enjoy the private hot tub just steps from the door or use the BBQ pit to create a meal to enjoy together. Area restaurants, wineries & golf are just minutes away! You are sure to enjoy!

Guest favourite
A bright living room features two light-colored sofas arranged around a dark coffee table, with a geometric patterned rug below. A wooden accent wall hosts a mounted TV and decorative plants. Warm lighting is provided by a side lamp, creating a cozy environment.
Home in Augusta
4.93 out of 5 average rating, 67 reviews

Modern Barnhouse Retreat

🏡 Relax and enjoy the incredible views on this home 🍃 Close to Katy Trail, Good News Brewery, Mount Pleasant Winery & Augusta Winery. Shuttle services also available! This spacious home is in the heart of wine country. Take some time with your friends, family or partner to unwind and put your worries behind you. This home offers enough room for 4 people to comfortably stay while also creating an intimate ambiance if you wish to enjoy a romantic weekend in wine country.

Top guest favourite
Home in Villa Ridge
4.95 out of 5 average rating, 216 reviews

Serenity Valley• Secluded Escape • No Cleaning Fee

Discover Serenity in this 675 sq ft Studio cottage on a private wooded lot. Cozy space with 1 queen bed & optional sofa queen bed for up to 4 guests. Relax on the patio, enjoy a bubble bath in the vintage clawfoot tub, or take in the panoramic woods view on the couch. Amenities include WIFI, washer/dryer, fully stocked kitchen, pack&play. Just 60 mins from downtown STL, 15 mins from Washington, 20 minutes from Six Flags. Your tranquil escape awaits! No pets allowed.

Guest favourite
A single-story home is depicted with a metal roof and a front door featuring a decorative window. Brightly colored flower pots filled with blooms are arranged along the path, complemented by landscaped greenery surrounding the property.
Tiny homes in Gray Summit
4.9 out of 5 average rating, 743 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- toys, books, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Top guest favourite
Home in Wildwood
4.99 out of 5 average rating, 94 reviews

3+ acres, fast wi-fi, garage parking, Koi pond

Rick’s Retreat is a charming rustic haven set on over three private acres, featuring a soothing Koi pond and waterfall. This spacious home is perfect for a memorable escape, blending rustic charm with modern comforts to make every guest feel at home. Whether you're seeking a relaxing weekend getaway, a family gathering, or a place to celebrate a special occasion, Rick’s Retreat offers everything you need for an unforgettable experience.

Guest favourite
A single-story house with a welcoming exterior features a bright teal front door and black shutters. Comfortable chairs are placed on the porch, surrounded by a well-kept lawn with colorful flowers. A screened-in patio offers additional outdoor space for relaxation.
Home in Augusta
4.95 out of 5 average rating, 55 reviews

Welcome to the Owls Nest!

Welcome to the quiet magical town of Augusta, enjoy the comforts of home with 2 bedrooms, ample living space, fully stocked kitchen, screened in patio to enjoy a cold drink or glass of wine while taking in a beautiful view. Walk to the local wineries or ride your bike on the Katy Trail, kids can enjoy the local town playground directly across the street. Local market, antique store and fine dining within steps.

Top guest favourite
A cozy seating area features an arrangement of two armchairs, one upholstered in blue and the other in green, complemented by a light brown recliner. A wooden coffee table sits at the center, adorned with a decorative tray. Soft lighting is provided by two lamps on either side.
Apartment in Washington
4.96 out of 5 average rating, 500 reviews

Elbert haus

The entire 2nd floor reserved to just one set of guest. Just three blocks from the Missouri Riverfront, historic downtown Washington, and near many fine restaurants. This early 1900s fully restored brick home offers a perfect place to lay your head after an exciting day. The house is located within walking distance of the Amtrak train station, close to the hospital and the trans Missouri Katy bicycle Trail.

Guest favourite
A modern kitchen features exposed brick walls and wooden beams overhead. A central island with seating is complemented by stainless steel appliances and white cabinetry. Natural light illuminates the space, highlighting decorative plants and a wall clock, creating an inviting atmosphere for culinary activities.
Home in Augusta
4.99 out of 5 average rating, 138 reviews

Augusta Haus

This early 1850's Augusta home has been lovingly revitalized to help those who stay here capture the essence of Augusta. While we have highlighted the craftsmanship of the original builder, we have also incorporated our vision of a comfortable historic home in the very heart of Missouri wine country. Great for couples as well as those traveling with friends or children. Relax and enjoy our Augusta Haus!

Top guest favourite
A modern studio cabin is elevated on pillars, surrounded by lush greenery. The exterior features dark wood siding and multiple windows, allowing natural light to illuminate the interior. A deck is visible, indicating outdoor space for relaxation.
Farm stay in Grafton
4.96 out of 5 average rating, 355 reviews

Pere Ridge Tree Escape with private hot tub

Welcome to Pere Ridge ! Enjoy the lovely setting of this romantic spot in nature. Pere Ridge is a custom Scandinavian inspired nature escape for two . Our elevated cabin is perched on a ridge with a deck that is surrounded by trees. Our hope is that you disconnect from life's stresses while at Pere Ridge. Our cabin is located in "the ridge " area of Grafton and is a 10 minute drive to Grafton.

Popular amenities for Defiance vacation rentals

  1. Airbnb
  2. United States
  3. Missouri
  4. St. Charles County
  5. Defiance