Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

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Guest favourite

Tiny homes in Pacific

4.96 out of 5 average rating, 203 reviews

Route 66 Railroad Shanty, a cozy artsy small space

This 536 s.f. house, believed to have once been a sleeping shanty for railroad crews switching shifts for the night. Fully renovated and updated in 2021 by a local artist, you will find custom metal art throughout, granite countertops and a very warm cabin feel featuring a kitchen and bathroom finished with locally sourced Missouri dark red cedar, 10 minutes from six flags, Purina farms 15 min from hidden valley and 45 min from downtown this place is in a great location and will not disappoint!

Guest favourite

Home in Augusta

4.99 out of 5 average rating, 238 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Guest favourite

Chalet in Innsbrook

4.97 out of 5 average rating, 117 reviews

Modern Lakefront Chalet at Innsbrook

Updated modern 2 bed 2 bath lakefront chalet located within the Innsbrook Resort. Enjoy private access and of the small Lake Powderhorn. This stylish chalet has 2 bedrooms each with a queen size bed. The open living room has a large sectional and a separate full size couch. The updated kitchen includes a stove, dishwasher, and a laundry unit. As part of the Innsbrook resort, you'll also have access to the many amenities, including golf course, swimming complex, various lakes, trails, etc.

Guest favourite

Guest suite in Saint Charles

4.95 out of 5 average rating, 338 reviews

Creekside Suite - Peaceful, Spacious, and Comfy

Enjoy your stay in a spacious walkout basement-level suite that includes bedroom, bathroom, living/dining room & patio. Bedroom has queen bed, dresser, desk & TV. Living room has futon, books, games & TV. TVs have Netflix. Suite has minifridge, microwave, toaster & coffee-maker. Eat at the dining table or sit up to the window counter to look out on the creek & woodlands behind the house. Situated in a quiet, safe neighborhood with parks & ponds. Just 8 miles from historic downtown St Charles.

Guest favourite

Cabin in Defiance

4.94 out of 5 average rating, 121 reviews

Hillside Cabin on 43 Acres w/ Private Lake & View!

Free from modern distractions, this 1-bedroom, 1-bath cabin in the heart of wine country is the perfect place to unplug and reconnect with nature! Immersed in lush woodlands, the Defiance vacation rental comes with all the amenities needed for a peaceful retreat, including a fishing lake, resident horses, and a fully equipped kitchen. Watch the sunrise over the hills from the porch swing before venturing off to Katy Trail, and later, head to Chandler Hill Vineyards located just minutes away!

Superhost

Tiny homes in Pacific

4.89 out of 5 average rating, 549 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- fun, colorful plastic dinnerware, toys, books, puzzles, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Guest favourite

Home in Villa Ridge

4.78 out of 5 average rating, 229 reviews

Sunny Modern Farmhouse - Pet Friendly Purina Farms

Our Coleman Road farm may look like a quaint older house from the outside, but inside you'll find a stylishly-updated modern farmhouse you'll be excited to spend time in. The rooms are filled with afternoon sunlight, and have been tastefully decorated to provide a tranquil and comfortable retreat. With a spacious living room, two bedrooms, a full bath, and separate kitchen and dining area, the space offers everything you need in a cozy and modern setting.

Guest favourite

Guesthouse in Marthasville

4.96 out of 5 average rating, 248 reviews

Hazel's House by the Katy Trail

In the heart of Missouri Wine Country. Within walking distance of the Katy Trail and Lake Creek Winery. Many wineries within a 25-30 minute drive. Enjoy a weekend getaway in a 2 bed 1 bath home. Hazel's House is clean, comfortable and private overnight accommodations. We are not a bed and breakfast, no food included, but there is coffee. Please make sure the location is suitable. We are located out in the country and the internet can be spotty.

Guest favourite

Home in Dittmer

4.95 out of 5 average rating, 410 reviews

Honeymoon Suite Camp Skullbone In The Woods

Romantic quiet cozy chalet for two! Vintage décor with all the modern amenities of home. Relax inside to unwind, kick back and watch a movie, surf the web via free wi-fi, curl up with a good book, open up a board game for a friendly challenge or share a drink with that special someone. Want some fresh country air? Lace-up those hiking boots and take like Camp Skullbones. . Enjoy the stars on the intimate deck with the glow from the gas fire pit.

Guest favourite

Farm stay in Lake Saint Louis

4.91 out of 5 average rating, 205 reviews

Updated Farmhouse 2 bdrm 2 bd 2 acres

Updated Farm House on 2 acres, 2 bedrm with 2 queen beds, 1 full size bed, fully equipped kitchen, living room, smart TV with roku, wifi, a full bathroom with double sinks and laundry, this house is a duplex, with 2 separate units, the upstairs is for Airbnb guest, the lower unit has a tenant, each unit has its own space and entrance. located in a central area, just 25 minutes from the St. Louis Airport. Lots of shops, parks, businesses.

Guest favourite

Loft in Washington

4.99 out of 5 average rating, 335 reviews

2nd Street Loft - Riverview

Complete Rehab, this historic 1883 storefront building hosts a well known artist and his gallery on the 1st floor. Above is your "loft space" close to wineries, Amtrak, featuring great views of the Missouri River. You’ll love this Downtown Washington location because of the walkable shops, bars, and restaurants many in historic buildings. The loft is great for couples, solo adventurers, and business travelers who can walk a flight of stairs.

Guest favourite

Home in Gray Summit

4.87 out of 5 average rating, 135 reviews

Sunset Mountain Privacy-Dog Friendly

10 rooms on the main floor with private entrance are all yours in this shared property. Host stays in lower level and the only places shared are the laundry room & outside. Great for families and dog owners attending Purina Farms. Great for girls weekend retreat. Great for birthday celebrations of all ages. Come enjoy the sunset, privacy, gardens, walking trails and the view! Above ground pool available June, July & August. 420 friendly.

Vacation rentals for every style

Get the amount of space that is right for you.

Popular amenities for Defiance vacation rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Stay near Defiance's top sights

Montelle Winery18 locals recommend

Historic Daniel Boone Home15 locals recommend

Chandler Hill Vineyards15 locals recommend

Klondike Park14 locals recommend

Wine Country Gardens11 locals recommend

Noboleis Vineyards10 locals recommend

Other great vacation rentals in Defiance

Guest favourite

Home in Augusta

5 out of 5 average rating, 68 reviews

Central Luxe 5br Home | Hot Tub & Views | 🥂 🍷

Guest favourite

Guest suite in Union

4.94 out of 5 average rating, 89 reviews

TJ’s Country Getaway *Dog Friendly*

Guest favourite

Guesthouse in St. Peters

4.96 out of 5 average rating, 47 reviews

Maple Tree Enchanted Guest House 1 bedroom 2 beds

Guest favourite

Rental unit in Moscow Mills

5 out of 5 average rating, 46 reviews

The Hidden Gem - Spacious 2BR Apartment On 7 Acres

Guest favourite

Cabin in Pacific

5 out of 5 average rating, 28 reviews

Catch The Dream:; An Immersive Equestrian Escape

Guest favourite

Rental unit in Lake Saint Louis

4.92 out of 5 average rating, 12 reviews

Patriotic Retreat with under the stairs playhouse

Guest favourite

Farm stay in New Haven

4.97 out of 5 average rating, 67 reviews

The Round Room Tower at Moy Mell Farm

Guest favourite

Home in Augusta

4.93 out of 5 average rating, 80 reviews

Honey Ridge Hideaway- Historic Home with Vineyard

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Quick stats about vacation rentals in Defiance

Total rentals
10 properties
Nightly prices starting at
$96 CAD before taxes and fees
Total number of reviews
620 reviews
Wifi availability
10 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool
Local attractions
August A. Busch. Memorial Conservation Area, Weldon Spring Conservation Area, and Chandler Hill Vineyards

Vacation rentals in Defiance

Top-rated vacation rentals in Defiance

Tiny homes in Pacific

Home in Augusta

Chalet in Innsbrook

Guest suite in Saint Charles

Cabin in Defiance

Tiny homes in Pacific

Home in Villa Ridge

Guesthouse in Marthasville

Home in Dittmer

Farm stay in Lake Saint Louis

Loft in Washington

Home in Gray Summit

Vacation rentals for every style

Hotels

Unique stays

Homes

Popular amenities for Defiance vacation rentals

Stay near Defiance's top sights

Other great vacation rentals in Defiance

Home in Augusta

Guest suite in Union

Guesthouse in St. Peters

Rental unit in Moscow Mills

Cabin in Pacific

Rental unit in Lake Saint Louis

Farm stay in New Haven

Home in Augusta

Quick stats about vacation rentals in Defiance

Total rentals

Nightly prices starting at

Total number of reviews

Wifi availability

Popular amenities

Local attractions

Destinations to explore