Vacation rentals in Des Moines County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Des Moines County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favourite
A spacious living room features a plush sectional sofa complemented by a cozy throw. Natural light filters through large windows, illuminating the wooden flooring. A 55" smart TV is positioned on a stylish media console, with decorative wall art adding a touch of style.
Home in Burlington
5 out of 5 average rating, 37 reviews

Quiet 3br Home • King Bed • Sleeps 5 • Fast WiFi

Welcome to Downtime on Denmark, a comfortable and thoughtfully updated ranch style home on Burlington’s south side. Inside you’ll find 3 bedrooms, a finished lower level family room, full size washer & dryer and fast WiFi. Located just minutes from downtown Burlington, the Mississippi River, Crapo & Dankwardt Parks, restaurants and shopping. Whether you’re visiting family, working in the area, or exploring Southeast Iowa, we invite you to slow down, settle in, and enjoy Downtime on Denmark.

Top guest favourite
A spacious kitchen area features white cabinetry and appliances, complemented by a brick accent wall. A central island provides additional counter space, while a dining table with wooden chairs accommodates meals. Natural light fills the room from overhead lighting and windows, creating an inviting atmosphere.
Apartment in Burlington
5 out of 5 average rating, 288 reviews

Downtown Living

Greater Burlington is rich in history and full of exciting attractions such as the PZAZZ! Entertainment Complex, minor league baseball, and Starr's Cave Park. Known for Snake Alley, "The Crookedest Street in the World," Burlington delights all with many attractions, a lot of history, and a little magic. The unit is located one block from the Mississippi River. Walking distance to several restaurants and pubs. Iowa welcome center is in the Port of Burlington on the river just east of the unit.

Guest favourite
A vibrant mural featuring a peacock is displayed on a white wall, contrasting with the rustic brick backdrop. The neon sign reading 'The Peacock Loft' adds a modern touch, while a dark staircase leads upward, highlighted by industrial-style lighting.
Loft in Burlington
4.98 out of 5 average rating, 309 reviews

The Peacock Loft / Spacious Artistic Loft

A whimsical, art-filled retreat. Filled with treasured pieces from years of travel and free-spirited living, the loft is now a space for rest, inspiration, and slow mornings. Layered with color, photography, books, and meaningful objects, it’s perfect for guests who love creative, collected spaces. Please note: this is an older urban building with character, multiple stairs, no elevator, and some city noise. Fans, sound machines, blackout curtains, and earplugs are provided.

Top guest favourite
A living room features a leather sofa, two vintage armchairs, and a round ottoman, creating a cozy seating arrangement. Natural light enters through large windows framed with sheer curtains. Dark wooden flooring contrasts with the light-colored walls and decorative art pieces are displayed throughout.
Home in Burlington
4.9 out of 5 average rating, 248 reviews

The Fleetwood Bungalow with Dreamy Porch

Welcome to The Fleetwood Inn! A charming, cozy one-bedroom bungalow in the heart of Burlington, Iowa. Right between our bustling business district and our nostalgic downtown, this little house has vast character. My favorite feature is all the original built-ins and beams. You will love the Western American inspiration and vintage finds, modern touches throughout, and dreamy details in every corner. Just added a Saatva Organic mattress for extra comfort.

Top guest favourite
A cabin sits atop a gently sloping area covered with gravel, surrounded by green grass. A deck with black railings is visible at the front of the cabin, showcasing large windows that provide natural light to the interior.
Cabin in Oquawka
4.98 out of 5 average rating, 103 reviews

The Shoreline Shanty

Take it easy at this unique and tranquil getaway. This cabin offers a outstanding view overlooking the river. You will find you are very close to everything Oquawka has to offer, restaurants, bars, parks, laundry mat, grocery store, car wash, & churches. ( FOR THOSE OF YOU WHO ENJOY BOATING ON THE MISSISSIPPI RIVER ARE LOCAL BOAT CLUB OFFERS BOAT SLIPS FOR RENT AND FREE TRAILER PARKING DURING YOUR STAY, UPON BOOKING DETAILS WILL BE PROVIDED)

Top guest favourite
A serene view of the Mississippi River at sunset, featuring vibrant hues of purple, pink, and orange in the sky. A boat gently navigates the water, leaving a soft wake, while lush greenery frames the scene on the riverbank.
Townhouse in Burlington
4.97 out of 5 average rating, 66 reviews

Mosquito Park Condo

Have fun with the whole family at this stylish 1890 building. There's a park that overlooks the Mississippi. And for the musically inclined there is a piano. Play your heart out! And it's just a short walk downtown. Where there's lots of great restaurants and cool shops. Rates are set by AirBnB. I offer weekly and monthly stays discounts. If there are any more than two guests there will be an additional charge for the third to eighth guests.

Top guest favourite
A historic home is set back from a brick-paved street, surrounded by lush greenery. Two trees frame the entrance, where a charming porch is accessed by a pathway. A lamppost stands nearby, enhancing the inviting atmosphere of the area.
Home in Burlington
4.99 out of 5 average rating, 196 reviews

Snake Alley Inn, a one-of-a-kind location.

Snake Alley Inn, a Victorian home nestled high on the hill on Burlington's famous Snake Alley. This 1894 landmark brick-paved street, was once recognized by Ripley's Believe It or Not as the Crookedest Street in the World. Built in 1860 this historic home is adorned with 3 bedrooms and 2 full baths. Located within walking distance to Burlington's dynamic downtown, where you'll find many shops, pubs and eateries.

Guest favourite
A cozy living area is framed by two white columns, providing a view of a muted brown sectional sofa adorned with blue accent pillows. A coffee table sits in front of the sofa, with natural light filtering in through the large window dressed with dark curtains.
Townhouse in Burlington
4.96 out of 5 average rating, 102 reviews

Comfy Corner East

Welcome to Comfy Corner East in downtown Burlington, Iowa. Enjoy your stay in our 1880 duplex that overlooks downtown. You are just a walk over the bridge from all the shops and restaurants on Jefferson St. and another block north to Burlington’s infamous Snake Alley - the crookedest road in America. Conveniently located close to downtown entertainment and all the Mississippi river front has to offer.

Guest favourite
Home in Danville
5 out of 5 average rating, 8 reviews

The Cabin

Escape to your own private, one-of-a-kind getaway in the peaceful countryside of southeast Iowa. Perfectly located near Burlington, Mount Pleasant, Fort Madison, and just two miles from beautiful Geode State Park, this retreat offers the best of both worlds—close to local attractions yet far enough away to truly unwind. Enjoy a dip in our salt water pool. Pool hours are 8:00 AM to 10:00 PM.

Guest favourite
A well-lit open living space features two white armchairs with wooden frames and decorative cushions. A round pouf is positioned on a soft area rug. A dining table with black chairs is visible in the background, along with a doorway leading to additional rooms.
Home in Burlington
4.89 out of 5 average rating, 160 reviews

Haven on North Hill

Walking distance to historic downtown Burlington, Snake Alley and the mighty Mississippi River, Haven on North Hill is a lovingly renovated 1910 house. With an open floor plan, contemporary decor, natural light and two inviting porches, Haven on North Hill provides you with an ideal and charming space for slowing down, relaxing, and making wonderful memories with family and friends.

Top guest favourite
A cozy living area features a plush green sofa facing a wall-mounted television. A small side table is positioned beside a comfortable chair. Natural light enters through a front door, while decorative wall art adds character to the space. A soft area rug covers the wooden floor.
Home in Burlington
4.96 out of 5 average rating, 57 reviews

Comfy Cottage

Welcome to Comfy Cottage in Burlington, IA. This 1950's single level home offers cottage-style charm with character-filled proportions. Situated in a quiet neighborhood within walking distance to both Dankwardt and Crapo parks with easy access to downtown by car in minutes. Our cottage is a comfy little place to relax inside watching TV or outside in the backyard by the fire pit.

Top guest favourite
The exterior of the spacious home is showcased against a vibrant sunset, highlighting its modern design. The building features a combination of white and grey siding, large windows, and a covered porch area. A concrete driveway leads to the garages, surrounded by well-maintained greenery.
Home in Sperry
4.98 out of 5 average rating, 42 reviews

Porches and Pines Farmhouse

Room for All! With three fully furnished levels, Porches & Pines can comfortably sleep 16 guests. Our country farmhouse is located in rural Southeast Iowa and is the perfect place for a country retreat. Built on the edge of a Christmas tree farm, you will enjoy the peaceful environment of the 4 porches and the sound of the wind whispering through the pines.

Popular amenities for Des Moines County vacation rentals