
Pet-friendly vacation rentals in Florence County
Find and book unique pet-friendly homes on Airbnb
Top-rated pet-friendly home rentals in Florence County
Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Florence County pet-friendly home rentals
Pet-friendly house rentals

Collins Quarters
Unique spot, kids loved the stairs, thought they were in the movie labyrinth.

Quiet, Clean & Spacious 4bd near I-95 & Hospital
An incredibly well-equipped, modern, new, beautiful facility with all the necessary and desired accommodations and luxuries.

2b/1.5bath brand NEW townhouse Closed to MUSC
This is the 2nd time I have stayed at this location in Florence. The place is very clean, comfortable beds, clean bathroom, and very easy to get into. The location was perfect for our needs, close to stores, food, and Francis Marion University. Wempy is a great host and very repsonsive. He answers mail within minutes and is always helpful. I would stay here again for sure. Thank you for a great stay!

Charming and spacious 4-bd 2 full ba WiFi, AC
Place was as advertised, clean, free of clutter and simply felt like home.

Cozy One Story Town House
Great space ....love the space and location will definitely be back. thanks for the awesome communication

Private Getaway on Smith Street
This place was everything we was looking for and more for the holidays! Raye was very prompt with any questions we had, and accommodated us beyond measures! I would definitely stay here again, the place is just like the pictures. With way more space than you need, in a very secluded quiet area.

"The Great Escape!"
Enjoyed our stay at Hazel’s home. We had an issue pop up with the home that Hazel quickly resolved. We appreciated how engaged Hazel was with ensuring we enjoyed our stay. Hazel has a beautiful, charming home and we will aim to stay here again if we are in the Florence, SC area.

Newly Renovated/Near Hospitals
This house was lovely. The decor was warm and inviting with a modern farm house vibe. The kitchen was well stoked with utensils, good pots and pans and storage containers. There was a keurig + k cups, sugar and basic spices. All of the appliances worked well. The linens were pristine and comfy. We truly enjoyed our stay here and will definitely come back next time we are in the area.
Private, pet-friendly home rentals

The Cottage by the Pool: Close to Interstates
We had a wonderful stay at this quaint poolside cottage while driving from Pennsylvania to Florida with our four dogs. It was the perfect overnight stop—clean, fresh-smelling, and super comfortable. The bed, sheets, and pillows were high quality, and we appreciated the soft towels and well-stocked coffee bar. The fenced yard was a huge bonus for the pups, and the flowers around the property added such a charming touch. Communication with Reeves was seamless. We only wish we could’ve stayed longer!

Darlington Farm House Near I-95 & Florence
Charming home with very nice details that made us feel special and welcome. Home was very clean and comfortable.

The Cottage at Dream Acres & Petting Zoo I-95/I-20
We had a wonderful night stay at the beautiful farm! They were so kind and it was awesome seeing Shannon working with the animals with a newborn! They were so kind, the fresh eggs were delicious and colorful, everything we needed was there, and the animals were great! Our daughter loved it and it was perfect place to stay with our dogs on our road trip as a quick stay.

Spacious, Historic Home for 12 - Near Myrtle Beach
We had a lovely stay, in town for our son’s wedding in Timmonsville. The house was perfect for our family for four days and three nights. Great space to host all 9 of us. It was prefect for this. Loaded of fun!!!

Gated and Private Catholic Hermitage house
We were traveling long distance with a small dog and wanted to give him a nice place to run around after the long car ride. This place was perfect and the owners are obviously animal lovers as evidenced by treats and food for animals in the kitchen and a very nice fenced area with a doggy care section stocked with bags and a disposal container along with pick up tools. The setting is so peaceful and rustic and it provided us with a very restful night’s sleep so we were able to tackle another long day of driving. The host, Lorraine, was wonderful to deal with very responsive. If we travel through this area again we will surely book this property again.

*Cottage Near Florence and I-95* 3 Bedrooms
I had a fantastic experience with this Airbnb! Everything was well organized, the host was incredibly welcoming and knowledgeable, and the activity itself exceeded my expectations. It was a perfect blend of local culture, fun, and learning. I would highly recommend this experience to anyone looking to add something unique and memorable to their trip. Can’t wait to book another one!

Quiet farmhouse near the beach
Was peaceful and quiet, had a lot of fun walking the trails and finding shark teeth. If you’re looking for a place where you can relax and enjoy nature I would highly recommend.

Peaceful country close to town.
This was just a short drive from Lake City and had plenty of space for our family. We enjoyed the peaceful country setting.
Destinations to explore
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- Myrtle Beach Boardwalk
- Garden City Beach
- Family Kingdom Amusement Park
- Huntington Beach State Park
- Love's a Beach
- Myrtle Beach SkyWheel
- The Pavilion Park
- Ripley's Aquarium of Myrtle Beach
- Caledonia Golf & Fish Club
- Ripley's Marvelous Mirror Maze
- Myrtle Beach State Park
- Litchfield Beach and Golf Resort
- Magnolia Beach
- WonderWorks Myrtle Beach
- Pawley's Island parking lot South
- Myrtle Waves Water Park
- Cartersville Country Winery
- Palm Plantation
- Captain's Quarters Building C - Litchfield By The Sea
- Myrtle Beach National
- Prestwick Country Club
- Public Beach
- Dragon's Lair Fantasy Golf
- Hollywood Wax Museum