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Vacation rentals in Mesopotamia

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mesopotamia

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Guest favourite
A panoramic view captures the surrounding mountains and lush landscapes, with a mix of greenery and water bodies visible below. La Piedra de Peñol is prominently featured on the right, overlooking the expansive reservoir and hills stretching into the distance under a bright blue sky.
Treehouse in El Peñón de Guatapé
4.94 out of 5 average rating, 123 reviews

Treehouse in El Peñol - 360° views of stone

Enjoy the sounds & privacy of nature at this unique cabin in the trees ATOP the closest mountain to Piedra de Peñol. *IMPORTANT NOTES!* Though nicely located in nature, IT'S A TREEHOUSE CABIN IN & ON TOP OF MOUNTAINS, not a resort downtown. *PRICES CHANGE DEPENDING ON NUMBER OF PEOPLE (AB&B's POLICY!) Located as high as La Piedra de Peñol with better views than from the rock as you're able to see it as well! The cabin's isolated away from roads, noises of civilization & surrounded by reserves.

Guest favourite
An outdoor deck area features a hammock hanging beside a small jacuzzi, complemented by a dining table for four. Large sliding doors provide a view into the interior space, where a cozy atmosphere is highlighted by warm lighting and natural wood elements.
Villa in Rionegro
4.97 out of 5 average rating, 155 reviews

Sweet Helen Llanogarden

Sweet Helen Llanogarden situado en el Tablazo-Llanogrande, a tan solo 10 minutos del aeropuerto internacional José Maria Córdova de Rionegro Antioquia, cerca a restaurantes, centros de eventos y malls, en el cual ofrecemos servicios de alojamiento para familias, amigos, parejas y viajes de negocios. En Sweet Helen Llanogarden encontrarás el espacio para pasar una estancia segura, tranquila y divertida, esta vez, rodeada de naturaleza y confort en la zona más exclusiva del oriente antioqueño.

Top guest favourite
Tiny homes in Peñol
4.97 out of 5 average rating, 252 reviews

Foresta 2: Modern cabin with views of the rock

FORESTA 2 is a modern cabin created with love for you to have an unforgettable stay in the middle of nature with total comfort. Enjoy the privileged views from the bedroom and deck, relax in the warmth of the jacuzzi, watch the dozens of birds that visit us and chill out on the trampoline net. FORESTA 2 is a great launchpad to explore Guatape, climb the rock and do kayaking, jet-ski, wakeboard, sailing, paraglading, horseback riding, hiking, getting a helicopter ride or having an ATV tour.

Top guest favourite
Tiny homes in Cocorná
5 out of 5 average rating, 14 reviews

luxury cabin with sauna, jacuzzy and private river

Enjoy the beautiful nature and tranquility of this luxurious accommodation with a sauna, jacuzzi, and private river terrace. Just 75 minutes from Medellín, this beautiful cabin is easily accessible by any car or motorcycle. The spectacular surroundings of Cocorná have much to offer, including paragliding, rafting, quad biking, and hiking trails along beautiful rivers. We are happy to assist you with transport or activities. We offer private transport from the airport! Includes breakfast!

Top guest favourite
A modern structure emerges from lush greenery, framed by vibrant plants and a manicured lawn. Large glass doors lead to a spacious deck, offering a view of the mountains and a colorful sky. Pathway stones create a welcoming entrance.
Home in La Ceja
4.93 out of 5 average rating, 44 reviews

Casa campestre, excelente ubicación hermosa vista!

Te invitamos a disfrutar de un hermoso espacio rodeado de naturaleza, con todas las comodidades para que puedas relajarte y descansar. Te sentirás como en casa. Lugar ideal para hacer teletrabajo (nómadas digitales) y estancias largas. A tan solo 10 minutos de La Ceja, 45 minutos del aeropuerto internacional y a una 1 hora de Medellín. Mascotas son bienvenidas. Adicionalmente ofrecemos clases de Yoga y terapias Ayurvedicas (Abhyanga/Swedana). Lugar perfecto para turismo "slow"!

Guest favourite
Cabin in Rionegro
5 out of 5 average rating, 33 reviews

The Ultimate Group House w/ Hot Tub & Amazing View

About this space 🌟 2 bedrooms, each with a double bed & private bathroom 🛏️ Double sofa bed in the living room 🛋️ Bathrooms with hot water & fresh towels 🚿 Living room with Smart TV & WiFi 📺 Private jacuzzi for relaxation 💦 Fully equipped kitchen 👩‍🍳 Gas BBQ grill for cookouts 🍖 Catamaran net, dining table & spacious deck/terrace 🌞 Private parking space 🅿️ Portable heater available 🔥 Breakfast available upon request, prepared by our staff with extra cost 🍳

Top guest favourite
A covered jacuzzi is visible in the foreground, with bubbling water inviting relaxation. In the background, two hammocks are strung between trees, set against a lush green landscape and a wooden structure that complements the serene setting.
Farm stay in Retiro
4.98 out of 5 average rating, 131 reviews

“Finca Antioqueña Auténtica con Todo el Confort”

Finca Sietecueros - Refugio Natural y Comodidad en un Solo Lugar Escápate a Finca Sietecueros, una casa campesina rodeada de bosques y montañas. Relájate en el jacuzzi, disfruta de las hamacas bajo los árboles o comparte historias en la zona de fogatas bajo un cielo estrellado. Ideal para parejas, familias y amigos que buscan paz, naturaleza y confort en un entorno único. ¡Reserva tu estancia y vive una experiencia inolvidable en contacto con la naturaleza!

Top guest favourite
A single-story house surrounded by lush greenery is showcased. The exterior features a welcoming porch with seating and a hammock. The structure boasts large windows for natural light, while landscaped bushes and trees frame the property, enhancing the serene rural setting.
Farm stay in El Carmen de Viboral
4.97 out of 5 average rating, 100 reviews

☼♥Villa Serena ♥☼ 360° Views-Nature-Serenity

* An incredible house with gorgeous 360° views* * 143 m² / 1539 ft² house size * Private Deck. Views of valley/Rionegro/Airport * Views of mountains * Privacy gate. Alarm. Parking for 5+ Cars * Fully stocked and equipped kitchen * 1 km / 0.6-mile dirt road to the house (any car will access) * There are two homes on the property, the main, larger house is Villa Serena where you will stay, the second home has a separate entrance and is not offered in Airbnb.

Top guest favourite
The cozy cabin is nestled in a lush green landscape, illuminated by warm outdoor lights. A wooden deck features comfortable seating, overlooking the serene surroundings. Large windows provide a glimpse of the interior, showcasing a warm and inviting space harmonized with nature.
Farm stay in Rionegro
4.95 out of 5 average rating, 279 reviews

Casa del Leñador | Secluded nature retreat

🪓 Retiro Cabin – Casa del Leñador es la casa de nuestros sueños. Una tiny home pequeña, acogedora y rodeada de naturaleza. El lugar perfecto para pasar unos días en pareja, un fin de semana en familia o trabajar remoto en un entorno sin distracciones. Despierta con el canto de los pájaros al amanecer y disfruta de una fogata en el deck al atardecer. En Retiro Cabin tendrás total independencia y una vista sin igual del campo en el oriente antioqueño.

Top guest favourite
A cabin is positioned on stilts surrounded by greenery, offering a panoramic view of the mountains. Nearby structures are visible on the hillside, set within lush gardens and fields that suggest agricultural activity. The sky is partly sunny, highlighting the natural beauty of the location.
Hut in El Carmen de Viboral
4.93 out of 5 average rating, 27 reviews

Cabaña Cielo Verde

Acogedora cabaña a 10 minutos del Parque principal de El Carmen de Viboral con increíble vista panorámica del oriente antioqueño, visibilidad de cultivos, cielo estrellado y acceso a bosque con caminos ecológicos para explorar. Servicios de cocina equipada, baño completo con vista al bosque, asador, hamacas y malla de descanso. Aclaración: La cabaña se ubica a 1300 metros por carretera sin pavimentar de la vía principal.

Top guest favourite
The interior of the cabin features a rustic design with bamboo walls and a high, woven roof. A dining table is set for meals, and a grill stands ready for outdoor cooking. Soft lighting is provided by hanging bulbs, creating a cozy gathering space.
Tiny homes in Vereda Bonilla
4.96 out of 5 average rating, 138 reviews

Cabaña Monarca

Es una hermosa cabaña en medio de un bosque nativo. Donde puedes disfrutar de la naturaleza, el bello cantar de los pájaros, y el relajante sonido de una cascada de agua corriente. También cuenta con un lago, el cual puedes apreciar desde el sendero que conduce a la cabaña. Es un espacio tranquilo, acogedor, que te permite desconectarte de lo cotidiano, de la monotonía y vivir una experiencia maravillosa.

Top guest favourite
An outdoor deck is shown, featuring a spacious jacuzzi surrounded by lush greenery. Sunlight filters through trees in the background, highlighting the serene environment. Two comfortable chairs are positioned nearby, inviting relaxation in the natural setting.
Cottage in Retiro
4.93 out of 5 average rating, 109 reviews

Casa campestre con jacuzzi al aire libre

Beautiful house, with wide and cozy spaces, full of natural light, perfect to get away from technology and the noise of the city, relax in a spectacular outdoor Jacuzzi and then enjoy a night at the fireplace. The sound of the small stream invites you to rest and enjoy nature: bird watching, resting on the grass, feeling the rain and the sun, dreaming under a sky.

Popular amenities for Mesopotamia vacation rentals

  1. Airbnb
  2. Colombia
  3. Antioquia
  4. Mesopotamia