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Vacation rentals in Mesopotamia

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mesopotamia

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favourite
An aerial view showcases a secluded property surrounded by greenery, softly illuminated by outdoor lights at dusk. The house is positioned on a hill, while paths lead to small seating areas enhanced by tropical plants. The inviting layout suggests a peaceful retreat.
Cabin in Peñol
4.9 out of 5 average rating, 101 reviews

An impressive house with a Jacuzzi

Take it easy at this unique and tranquil getaway. This house in a subdivision with 3 spacious rooms, a Jacuzzi, a barbecue, access to the dam, and a stunning view of the Peñol stone ★"My wife explored the options and feels that your beautiful villa is her favorite in El Peñol." - Marcela, September 15 Exclusive condominium with few houses which will provide security during your stay, large terrace for your meetings and enjoyment with family or friends. Very safe and comfortable place Newly furnished☞ house.

Superhost
Villa in Peñol
4.91 out of 5 average rating, 160 reviews

Private luxury Retreat Spa, lake acces

Our concept is privacy and comfort in the middle of nature, each room has a high standard king bed for your comfort, all rooms have a direct view of the lake, balcony and private bathroom; the jacuzzi located at the top of the mountain under the imposing eucalyptus trees . You will enter to the house through the roof, to findh a wonderful view of the lake, we have .created tailor-made experiences, traditional cuisine, a chef, water activities, and our spa. Paddle boards and canoe are included

Top guest favourite
Apartment in Guatape
4.97 out of 5 average rating, 158 reviews

Apartment with reservoir view and hot tub on the balcony

Hello! There's construction in a building nearby Mon-Fri, 7 AM-5 PM. We apologize for any inconvenience. Thanks for understanding Relax with family at this peaceful place and enjoy the sounds of nature during your stay . Beautiful view of the Guatape Reservoir . Less than a 10 minute walk to the center of town restaurants , bars , park , zocalos , shopping , and cafes . One double bed and one sofa bed and private heated jacuzzi included for your stay in beautiful Guatape , Colombia !

Top guest favourite
A modern cabin is positioned on a hillside, surrounded by lush greenery and offering panoramic views of the surrounding landscape, including a prominent rock formation and a serene body of water in the foreground.
Tiny homes in Guatape
4.98 out of 5 average rating, 627 reviews

Foresta: Modern cabin overlooking the Rock

FORESTA is a modern cabin created with love for you to have an unforgettable stay in the middle of nature, with total comfort. Enjoy the privileged views from the deck, chill out in the jacuzzi, watch the dozens of birds that visit us, or have a chat by the fireplace in the living room. FORESTA is a great launchpad to explore Guatape, climb the Rock and do kayaking, jet-skiing, wakeboarding, sailing, paraglading, horseback riding, hiking, helicopter tours or ATV rides. You choose!

Top guest favourite
A modern house is displayed with expansive glass walls, revealing a generous patio area. A private jacuzzi is surrounded by seating arrangements and tropical plants. The second-floor terrace features outdoor dining furniture, enhancing the view of the surrounding landscape.
Cottage in El Peñol
4.98 out of 5 average rating, 105 reviews

House*Jacuzzi/Wi-Fi Family*access to dam/Guatape

Enjoy a unique experience in this modern house with a panoramic view of the Guatapé dam. For families and groups of friends looking for rest, comfort, with modern design, spacious terraces and a breathtaking view over the dam. ✔ Direct access to the dam ✔ Private jacuzzi ✔ Spacious and bright spaces ✔ BBQ terrace ✔ WiFi ✔ Private parking Experience unforgettable moments surrounded by comfort and tranquility, just minutes from the boardwalk and Guatape's main attractions.

Top guest favourite
An outdoor dining area features a wooden table set with dishes in a tranquil garden setting. Nearby, a mini hot water pool is visible, surrounded by lush greenery and steps leading to additional seating areas. Natural elements enhance the serene ambiance.
Cabin in El Peñol
5 out of 5 average rating, 314 reviews

Milagros Home-Mini private heated pool!

🍃A private experience, not just a cabin. Milagros Home is a modern artisan cabin with many spaces in one place, with a privileged view of the El Peñol-Guatapé reservoir, which allows you to enjoy a landscape and dreamlike sunrises. Not even with the best photographs can I explain what it feels like to be here, it is a place where you feel that time stops and you become one with the environment. Here you don't share spaces, it's a single cabin completely for you.🍃

Top guest favourite
Cabin in Rionegro
4.95 out of 5 average rating, 335 reviews

Nature & View | Cabin with a view

Nature & View just 8 min from JMC Airport Ideal for couples or travelers in transit. Our cabin offers a view of the valley, a quiet atmosphere, self check-in, an equipped kitchen, fast wifi, and all the comforts to relax. For your convenience, there are restaurants with home delivery and inside the accommodation you can buy cold drinks and snacks when you need them. 🚘 Trusted Uber driver Relax, order your favorite food and enjoy the view. Book your date!

Top guest favourite
A single-story house surrounded by lush greenery is showcased. The exterior features a welcoming porch with seating and a hammock. The structure boasts large windows for natural light, while landscaped bushes and trees frame the property, enhancing the serene rural setting.
Farm stay in El Carmen de Viboral
4.97 out of 5 average rating, 106 reviews

☼♥Villa Serena ♥☼ 360° Views-Nature-Serenity

* An incredible house with gorgeous 360° views* * 143 m² / 1539 ft² house size * Private Deck. Views of valley/Rionegro/Airport * Views of mountains * Privacy gate. Alarm. Parking for 5+ Cars * Fully stocked and equipped kitchen * 1 km / 0.6-mile dirt road to the house (any car will access) * There are two homes on the property, the main, larger house is Villa Serena where you will stay, the second home has a separate entrance and is not offered in Airbnb.

Top guest favourite
A charming chalet is depicted beside a serene natural lake, framed by lush greenery and vibrant aquatic plants. The structure features rustic wooden details, large windows, and an expansive deck, inviting outdoor relaxation and enjoyment of the tranquil surroundings.
Cabin in Santa Elena
4.99 out of 5 average rating, 169 reviews

Lake Chalet | Private Jacuzzi + Nature

🌿 Chalet del Lago – St. Helena Escape to a natural retreat with a private lake, large windows and a peaceful setting. With very complete equipment and distribution. Just 10 minutes from the main park, enjoy the birdsong, the sound of water and the cool climate of the Antioquia countryside. Ideal for couples, families or a relaxing getaway. Nature, tranquility and unforgettable moments in one place. 💛✨ ✅ We are pet friendly🐶🐈

Top guest favourite
A modern concrete home is nestled among lush greenery, showcasing its unique architectural design. The multi-level structure features large windows that provide expansive views of the surrounding landscape, while a spacious rooftop terrace offers outdoor seating against a backdrop of mountains.
Home in Antioquia
4.95 out of 5 average rating, 222 reviews

Architectural Award Winning Home - Lakeside, Views

Winner of the SARA NY Design Award of Honor, & recently featured in AXXIS Architectural Magazine, this hilltop hand poured concrete home is located in the most exclusive area of Guatape, 10 min from town 360’ views, lake access & only 3 other properties on the 4 acre site, the setting is quiet & private Enjoy sunset views from the rooftop balcony or plunge bath. Note: Access is a 100 meter path with a moderate climb

Guest favourite
A wooden deck features a private jacuzzi surrounded by lush greenery and vibrant palm trees. Scenic hills and a colorful sky create a serene backdrop, while outdoor seating is visible nearby, inviting relaxation in nature.
Cabin in El Peñol
4.95 out of 5 average rating, 135 reviews

Sun Palm Cabin: Nature and Comfort in El Peñol!

Discover an exceptional retreat surrounded by nature, where every detail is designed to offer you an unforgettable experience. This cabin combines elegance and comfort. Relax in your private jacuzzi while enjoying breathtaking panoramic views in a serene environment. Perfect for a romantic getaway or rejuvenating vacation, you will find the ideal harmony between privacy and natural beauty. Your perfect escape awaits!

Guest favourite
Farm stay in Rionegro
4.95 out of 5 average rating, 300 reviews

Casa del Leñador | Secluded nature retreat

🪓 Retiro Cabin – Casa del Leñador is the house of our dreams. A small, cozy tiny home surrounded by nature. The perfect place to spend a few days as a couple, a family weekend, or work remotely in an environment without distractions. Wake up to birdsong at dawn and enjoy a campfire on the deck at dusk. At Retiro Cabin you will have total independence and an unparalleled view of the countryside in eastern Antioquia.

Popular amenities for Mesopotamia vacation rentals

  1. Airbnb
  2. Colombia
  3. Antioquia
  4. Mesopotamia