Vacation rentals in Osborn Medical Center, Phoenix

Best Little Guesthouse in Melrose !

Historic guesthouse in the heart of the Melrose District! EV charger! Walking distance to restaurants, bars, coffee shops, the famous Melrose Vintage shops, grocery stores, LA Fitness and more! Want to head downtown to Chase Field, Talking Stick Arena for a game or a show? Campbell Street Light Rail station is only five short blocks away! No need for a car, you can take the Light Rail from Sky Harbor International Airport, save your money for entertainment! Off street parking if you have a car!

The Beverly Bungalow 1BR/BA in the 🖤 of Phoenix

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2 (up to 4 using an air mattress). Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

Charming Redbrick Cottage

Enjoy the perfect balance of comfort and privacy in this beautifully remodeled 670-square-foot guest house. Fully updated in 2015, every surface has been refreshed with modern finishes and thoughtful details throughout. The uniquely attached garage has been converted into a spacious bedroom, adding versatility and charm. The kitchen is a highlight, featuring contemporary cabinetry with a built-in lazy Susan, in-cabinet trash receptacle, and a refrigerator equipped with filtered water & ice!!

Vintage French Film Set in Heart of Coronado

Rest well in a space that feels like a vintage French film set - a one-off vision of a Phoenix designer. 1931 duplex reimagined for unique looks AND function by a team with deep Airbnb experience. Combo of vintage and new, original and updated, everything here is designed for a memorable and comfortable experience. Short walk to some of the best foodie and coffeehouse destinations of Phoenix, 5 minutes to downtown, and yet in the heart of one of the most vibrant neighborhoods Downtown Phoenix.

Poolside Guesthouse with Private Patio in Midtown

Welcome to the Poolside Guesthouse! Everything has been designed with you in mind to help you enjoy your time in Phoenix! Furniture and fixtures have been selected for your comfort and to help maximize the space. The Poolside Guesthouse has fantastic outdoor spaces for you to enjoy our beautiful weather & offers one of the best central locations with easy access to the airport, shopping, arts district, museums, bars and restaurants. TPT License #21525000 City of Phoenix License #2023-4161

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Downtown Phoenix Private Casita - Story & Sol

Story & Sol is a new, fully equipped casita in the heart of FQ Story neighborhood in Downtown Phoenix. Stroll palm-lined streets and admire historic Arizona homes with charming landscapes as you discover all that Phoenix has to offer. Truly a cozy oasis in the heart of the City... minutes from restaurants, coffee shops, bars, farmers markets, & museums. Located off the I-10, Story & Sol is the perfect launch pad for adventures across the Valley of the Sun in our beautiful Grand Canyon state.

Private Casita w/ Pool* & BBQ in Historic Melrose

*PLEASE READ HOUSE RULES IN "OTHER THINGS TO NOTE" AREA BEFORE BOOKING* Under no circumstance can one book the Airbnb for another guest . This violates our house rules as well as Airbnb policy. Read more under HOUSE RULES for more details. Our cozy casita is located in the Woodlawn Park neighborhood, a short car ride from the Melrose and Willo Districts. Located near some of the best restaurants in Phoenix, this is the perfect stay for visitors who want to explore the local food scene.

Urban Green House The Garden House

The Urban Green House brings farm life to the urban core. We offer fresh eggs from our backyard hens and gardens for guests to enjoy. We also live green-using solar panels, recycling, and composting. Sarah and Ryan live locally and are available to meet any needs that arise. We are located in a quiet and safe 1950s neighborhood, close to local restaurants, coffee shops, Encanto park, direct access to both the I-10 and I-17 freeways, and only 8 miles from Phoenix Sky Harbor Airport.

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)

Charming Guesthouse w/ Full Kitchen & Pool

You'll love your private stay in our charming space, centrally located in Phoenix's historic Melrose District. It's perfect for folks staying several days: powerful air conditioning, private laundry room, and access to a kitchen and our outdoor pool. You'll be a 10 minute drive from downtown Phoenix and a 15 minute drive from Sky Harbor Airport. With a private entrance and a dedicated covered parking spot, your stay couldn't be more convenient!

Coronado Master En-Suite (Private Entrance)

Less than 3 miles from Chase Field & Concert venues in Downtown Phoenix! See also Coronado Private Casita it shares the same back yard. We have a 100k+ backyard heated pool with 75” tv. See house rules for heating! The private entrance through the backyard to our large 440 sqft master en-suite suite (sound dampened from main house) with duel vanities, Claw foot bathtub and large separate shower. California King bed!