
Vacation rentals in Panamá Province
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Panamá Province
Guests agree: these stays are highly rated for location, cleanliness, and more.

Best Location – Spacious Luxury Apartment for 8
Welcome to our spacious and elegant apartment, designed to comfortably host up to 8 guests in the heart of Casco Viejo. Located directly in front of one of the most beautiful and lively plazas in the historic district, you’ll be surrounded by top restaurants, cafés, and vibrant city life. The building also features an elevator for your convenience and access to a rooftop, perfect for relaxing after a day exploring the city. Its prime location allows you to easily discover the best attractions

Apt with unique views to remember
Pasarás una Experiencia con estilo, alojamiento céntrico. acceso a líneas de buses y el Metro, restaurante , grocery store 24 horas, y una vida nocturna genial, casinos, cinta costera, iglesia del Carmen. casco antiguo a minutos en uber. compras. Soho Mall, Multi Plaza Mall y Albrook Mall. Piscina para adultos y niños. Bar, restaurante, rooftop vistas panorámicas, coworking, gym. Una habitación Con cama queen y un sofá cama en la sala para huéspedes extras (costo xtra 15.00 pp x noche)

CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES
Espectacular ático Duplex en Panamá Casco antiguo, de 265 M2 con balcones, terrazas privadas exterior, cuenta con una salón jardín interior, un comedor, 3 hab. (+ sofá cama en studio), recientemente reformado con concepto Loft, diseño exclusivo único y confortable, en la mejor zona del Casco viejo, perfecto para relajarse y desconectar, cocina , lavavajilla, sala con lavadora. piscina compartida, asc, portero 24-7, no se permiten niños que no sepan nadar, gran variedad de ocio en la zona.

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Luxury Mid-Century Apartment In Casco Viejo
Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

Modern apt ocean view in heart of Panamá yoo tower
Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Luxury Balcony Stays + Pool Casco Viejo
Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Private parking & rooftop | Studio Casco Center
This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Tropical Haven with Pickleball/Yoga Platform
Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Loft 3b Old Town Best! It's 150 m2 (492 feet)
Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.
Popular amenities for Panamá Province vacation rentals
Other great vacation rentals in Panamá Province

Most Beautiful Loft in the Heart of Casco Viejo

Old Town • Bright & Cozy 2BR Central Loft

The Don Quixote Loft by AcoModo (Ocean View)

Unique Luxury 3-story Loft at the Yoo

Casco Antiguo Apartment with Balcony & Stone Wall

w* | Luxury 2BR in Old Town

Casa Condal - Your Private Nature Eco-Retreat

Amazing loft with Casco charm in the best location
Destinations to explore
- House rentals Panamá Province
- Pet-friendly rentals Panamá Province
- Boutique hotels Panamá Province
- Rentals with a patio Panamá Province
- Loft rentals Panamá Province
- Hotel rooms Panamá Province
- Villa rentals Panamá Province
- Rentals with a home theater Panamá Province
- Nature eco lodge rentals Panamá Province
- Townhouse rentals Panamá Province
- Rentals with an accessible height bed Panamá Province
- Boat rentals Panamá Province
- Vacation home rentals Panamá Province
- Fitness-friendly rentals Panamá Province
- Rentals with breakfast Panamá Province
- Rentals with lake access Panamá Province
- Rentals with a hot tub Panamá Province
- Rentals with a fireplace Panamá Province
- Serviced apartment rentals Panamá Province
- Waterfront rentals Panamá Province
- Rentals with outdoor seating Panamá Province
- Rentals with pools Panamá Province
- Rentals with beach access Panamá Province
- Guesthouse rentals Panamá Province
- Cabin rentals Panamá Province
- Apartment rentals Panamá Province
- Private suite rentals Panamá Province
- Bed and breakfasts Panamá Province
- Rentals with a sauna Panamá Province
- Condo rentals Panamá Province
- Rentals with a firepit Panamá Province
- Hostel rentals Panamá Province
- Smoking-friendly rentals Panamá Province
- Tiny house rentals Panamá Province
- Beachfront rentals Panamá Province
- Rentals with an EV charger Panamá Province
- Family-friendly rentals Panamá Province
- Rentals with a washer and dryer Panamá Province
- Rentals with a kayak Panamá Province
- Things to do Panamá Province
- Tours Panamá Province
- Nature and outdoors Panamá Province
- Food and drink Panamá Province
- Sightseeing Panamá Province
- Art and culture Panamá Province
- Things to do Panama
- Food and drink Panama
- Nature and outdoors Panama
- Sightseeing Panama
- Art and culture Panama
- Entertainment Panama
- Tours Panama





