Vacation rentals in Port Byron

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Top-rated vacation rentals in Port Byron

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Guest favourite

A cozy living room area features two armchairs and a spacious couch, all adorned with patterned covers. A wooden coffee table sits centrally on a soft rug, complemented by a stylish lamp on a side table. Natural light enters through the nearby window.

Guest suite in Le Claire

4.92 out of 5 average rating, 387 reviews

Paws & Relax Guest Suite #1

Please keep in mind, this is a second story suite. There is 1 flight of stairs. Paws & Relax Guest Suite is located a block and a half up from beautiful historic downtown LeClaire, next to the scenic Mississippi River. Plenty of shopping, restaurants, a distillery & brewery- all within walking distance! There is an outdoor patio with seating & table along with a porch for rainy days. Close enough to walk downtown, but just far enough to enjoy some peaceful rest. The perfect home away from home!

Guest favourite

The exterior of a two-story home is displayed, featuring a light-colored facade and a welcoming entrance with a sign labeled 'Rescue River Retreat.' A wooden fence surrounds the property, providing privacy, while a staircase leads to the upper level.

Home in Le Claire

4.89 out of 5 average rating, 118 reviews

Rescued River Retreat

A renovated 1890's two-story home overlooking the Mississippi. The upstairs has 2 large bedrooms: one with 2 full size beds, the other a queen size bed. Additionally, the living room has a sleeper sofa, so easily sleeps 8. The kitchen offers everything for cooking a family meal and the dining room has a large table. Enjoy the charming vintage bathroom while taking a soak in the claw foot tub. Whether you stay a weekend or more the laundry room has a wash sink, washer and dryer for you to use.

Top guest favourite

The charming exterior features a white home with wooden shutters, a welcoming front door, and a small set of steps leading to the entrance. A grassy area surrounds the house, complemented by a gravel pathway that provides access.

Home in Le Claire

4.96 out of 5 average rating, 418 reviews

Aire Leclaire 2-bedroom home

Your family will be close to everything when you stay at Aire Leclaire! Within walking distance from downtown and 2 blocks from American Pickers. This modern 2 bedroom, 1 bath home is a block away from the tugfest parade route. A barnyard turned farmhouse in the 1940’s, this home completely remodeled with the modern farm charm it has today. In town for a day or several, enjoy outdoor amenities, a lighted deck, outdoor couch, and table. Inside, a modern LED fireplace mixed with rustic beauty.

Top guest favourite

The cottage's exterior features a welcoming facade adorned with colorful flowers and greenery. A spacious deck is bordered by stone pathways, while large windows allow natural light to flood the living spaces. Mature trees provide shade in the surrounding area.

Cottage in Le Claire

4.97 out of 5 average rating, 529 reviews

Mississippi Overlook Cottage. Dogs welcome.

Settle into a fully renovated 1910 cottage perched on a steep hill above Buffalo Bill Cody’s original homestead. Enjoy a charming park right behind you and stunning river views in front. The cottage comfortably accommodates up to six guests. - The cottage is located on a steep hill. - You will hear trains, as LeClaire is a river and train town. 🚂🌊 - This is a wooded property, so expect sticks, leaves, and bugs. 🌿🐞 - There are many steps. 03/24/26. Cody Rd is under construction.

Top guest favourite

A modern cabin is set on a landscaped lot with a gravel path leading to the entrance. The structure features a mix of dark siding and wood accents, surrounded by open fields and distant tree lines, offering a serene rural setting.

Cabin in Princeton

4.96 out of 5 average rating, 149 reviews

Private & Modern. Near river and wildlife refuge!

Experience the outdoors in comfort from this modern cabin, situated next to the 2200 acre Princeton Wildlife Management Area, and the nearby Mississippi River. It is ranked as the most “Wish Listed” Iowa listing of 2025 on Airbnb. Are you into hiking, biking, fishing, hunting, boating, or other water, winter, and summer sports? This cabin can support it all! Sit back and relax on the large deck while enjoying a coffee & the local wildlife, flora, & fauna of the Mississippi Valley Region.

Top guest favourite

The entrance features a welcoming porch with a ceiling fan and decorative lights. A white picket fence includes a painted flower sign, while steps lead to a green door framed by large windows. Rocking chairs are placed on the porch, inviting relaxation.

Cottage in Le Claire

4.97 out of 5 average rating, 239 reviews

Grasshoppers Guest House Too, cozy, cute, cottage!

This cozy cottage is 1000 sq. feet of charm. You are in the heart of downtown, historical Le Claire. Your home away has everything you will need for your stay. The porch overlooks downtown, nestled in with views of the Mississippi River. Shops, dining, brewery & distillery all to enjoy. visitleclaire.com has monthly activities & festivities. Birthplace of Buffalo Bill Cody & home to Mike Wolfe on American Pickers. You may even see him unloading treasures at his shop Antique Archaeology!

Guest favourite

A historic Queen Anne Victorian home is showcased with vibrant blue siding and intricate architectural details. The front porch, adorned with hanging flower baskets, invites guests to relax. Lush greenery and a well-maintained lawn surround the property, complementing the charming façade.

Home in Le Claire

4.92 out of 5 average rating, 154 reviews

"The 504" - Historical Victorian Guest House

Prepare to walk back in time in this historical 1860 Queen Anne Victorian. Centrally located to restraunts, shops, wineries, a brewery & a dilstillary. River view w/private parking & fire pit. The property has a fun party room" w/TV, high top bar tables, sleeper sofa, kerug coffee maker, hot tea kettle, toaster oven, microwave & refridgerator. There is a comfortable living room with 2nd TV, 2 bedrooms w/queen beds & Victorian inspired bath w/clawfoot tub, shower & high tank toilet.

Top guest favourite

A waterfront area features several gray lounging chairs arranged around a fire pit, with views of a spacious wooden deck and a house in the background. Trees provide shade, and a hot tub is visible near the deck.

Home in Hampton

4.91 out of 5 average rating, 141 reviews

Mississippi River with Hot Tub Views!

The Hampton House is located right on the Mississippi and minutes away from the Home of the American Pickers(History Channel) Looking for a getaway with beautiful views! This house offers sunset views from the kitchen, living room and master suite. Feel right at home with amenities including a Keurig coffeemaker, fully equipped kitchen, smart TV’s, fresh linens and towels as well a washer & dryer on site.After a long day out exploring nothing beats our brand new jacuzzi hot tub!

Guest favourite

A serene riverside view is captured at sunset, highlighting calm waters and distant trees. A picnic table is positioned on a snow-covered area beside the river. The warm hues of the sunset reflect gently on the water, adding a peaceful ambiance to the scene.

Cottage in Rock Island

4.87 out of 5 average rating, 228 reviews

Rock River Escape

Enjoy your coffee, a nice bbq dinner, glass of wine, a good book, or just enjoy the sweeping views out of this cute bungalow. With 180 ft of unobstructed river views and river access, bring your fishing poles and get ready to relax and enjoy watching the water slowly drift by at this centrally located bungalow in a quiet residential neighborhood. Firepit with firewood provided. No parties allowed so please do not inquire about them.

Top guest favourite

The exterior of the Wide River Winery is showcased, featuring a stone facade and welcoming signage. Colorful banners hang from the building, while outdoor seating with small tables and chairs is positioned along the sidewalk, inviting guests to enjoy the lively atmosphere.

Apartment in Le Claire

4.94 out of 5 average rating, 340 reviews

Wide River Winery Inn

Located in downtown historic LeClaire, a quaint but lively town on the Mississippi River. Two blocks from the American Pickers and a short walk to The Crane and Pelican and the La Ragazza Tuscan Kitchen & Bar. Up the street is Mississippi River Distilling Company and the delicious Brewery and next door is Cody Road Coffee. Guests are invited to sample our award winning wines and to choose a complimentary bottle of wine to enjoy.

Top guest favourite

A cozy cottage is set against the backdrop of the Mighty Mississippi River. It features a welcoming red door and a spacious porch furnished with chairs and a table. Well-maintained landscaping includes a lawn, flower pots, and a swing, enhancing the outdoor experience.

Cottage in Port Byron

5 out of 5 average rating, 143 reviews

River Current's Cottage

River Current's Cottage is a hidden gem tucked on the banks of the Mighty Mississippi River. This cozy cottage has magnificent views of the river, no matter what time of year you chose to stay the views & cottage will offer you endless relaxation and enjoyment. With wonderful options for dining just minutes away in Port Byron or driving a few more minutes to LeClaire, IA you can truly make this a relaxing getaway.

Guest favourite

Bungalow in Bettendorf

4.87 out of 5 average rating, 216 reviews

River Retreat

Welcome to our River Retreat. This house is situated at the end of a quiet dead end road right on the Mighty Mississippi River. Fully furnished with Wifi, washer/dryer and everything you need for a quiet and relaxing get away. Enjoy the river views from the deck and 3 season porch or relax in living room with a movie. Extra furnishings include a fire pit and charcoal grill. Book your stay today!!!