
Hotel vacation rentals in St. Charles County
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Top-rated hotels in St. Charles County
Guests agree: these hotels are highly rated for location, cleanliness, and more.
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Popular amenities for St. Charles County hotels
Family-friendly hotels

Private room in Wentzville
4.63 out of 5 average rating, 64 reviewsMidwest Guest Room "E"
ElijahRating, 5 stars13 months ago
The room was perfect for what I needed. Very simple but definitely worth the price. It was nice to come back to a quiet place after working doubles and being able to relax and sleep.

Private room in Wentzville
4.73 out of 5 average rating, 91 reviewsMidwest Guest Room "B"
JimRating, 5 stars1 month ago
We have stayed at this location several times and always have enjoyed ourselves. It is a great value for the money.
Guest favourite

Hotel room in St. Louis
4.87 out of 5 average rating, 713 reviewsBlue Spruce Room Queen Bed at BnB in CWE!
ChristopherRating, 5 stars1 month ago
We enjoyed our stay and would recommend for those who are staying in St. Louis or plan to. Be sure to plan ahead and secure one of the parking places, as it was difficult to find parking spot on the street.

Private room in Wentzville
4.61 out of 5 average rating, 71 reviewsMidwest Guest Room "A"
Mary PatRating, 5 stars4 months ago
This placed worked perfectly for us. It was close to where we needed to be, and also close to restaurants and other businesses. The room we stayed in was clean, had comfortable beds and good water pressure in the shower. We'll definitely be coming back to visit and this will be our first choice in lodging. Thank you!

Private room in Wentzville
4.76 out of 5 average rating, 63 reviewsMidwest Guest Room "C"
JimRating, 5 stars23 months ago
This place is perfect for us every time we come to Wentzville. The campus setting is peaceful, and the location is handy to the places we love to visit.

Private room in Wentzville
4.73 out of 5 average rating, 22 reviewsMidwest Guest Room "H"
EmilyRating, 5 stars9 months ago
This place was exactly what I needed for a quiet work location. The room was spacious, and the stay was quiet, without interruption, allowing me to get much-needed work done. The bed was comfortable, and the two large desks allowed me plenty of room to spread out. The wifi worked well for my needs. I would definitely stay here again for a quiet work time or a much-needed retreat from hectic daily life.
Guest favourite

Hotel room in St. Louis
4.87 out of 5 average rating, 632 reviewsEvergreen Room Queen Bed at BnB in CWE
NettaRating, 5 stars1 month ago
Not only was the stay perfect my partner left his cellphone at the Airbnb and without hesitation they shipped his phone out for us very kind and caring people !

Private room in Wentzville
4.7 out of 5 average rating, 90 reviewsMidwest Guest Room "D"
JimRating, 5 stars10 months ago
We’ve stayed here several times while visiting our grandchildren. It’s quiet and convenient and a great value for the money. Not a lot of amenities (no TV) but it’s got comfortable beds.
Hotels with a patio

Private room in St. Louis
5 out of 5 average rating, 10 reviewsLovely spacious 2 room King suite, super quiet
KathyRating, 5 stars19 months ago
I'm a repeat visitor at Tim's. I have occasional work in the area and appreciate that his place is so close to my destination. The place is clean and comfortable. Appliances are all new. Wifi was solid for me to stream a show and maintain fast remote connection to my client's site for after hours work. There's Aldi's grocery a few blocks away so I shop and eat in for time and cost savings. Tim is super responsive, always helpful.
Top guest favourite

Hotel room in Saint Charles
5 out of 5 average rating, 13 reviews#3 Betty Bloomer Le Velo Inn
KristaRating, 5 stars4 weeks ago
We had never been to St. Louis or the surrounding area prior to booking our stay - and honestly would come back again just to book at Le Velo Inn! It is a great launch for day trips into St. Louis, but it could easily be the primary destination itself. There are many neat shops, cafes, and restaurants within close proximity, yet we found it to be very peaceful and relaxing. It is evident that the owners care about the history and character of the building. As individuals who were new to the area, we felt like we were invited into the history of St. Charles and were able to see what makes it so special. The room/suite itself was wonderful and extremely well-equipped with everything you would need for a getaway, and a luxurious one at that! It was nice to have our own private entrance to the street as well and parking was very easy and convenient. We highly recommend and would absolutely stay here again! Le Velo Inn was a gem that made our trip even more memorable!
Guest favourite

Hotel room in Saint Charles
5 out of 5 average rating, 14 reviews#4 Penny Farthing Le Velo Inn
PeterRating, 5 stars2 weeks ago
This was a great place. My wife and I enjoyed it very much. We enjoyed the sitting area in the back and walking down the street to the little shops and restaurants.
Top guest favourite

Hotel room in St. Louis
5 out of 5 average rating, 12 reviewsLuxury Retreat, Hot Tub,En-Suite Bath, Location+
KaraleeRating, 5 stars2 weeks ago
Really enjoyed our stay! The unique ambiance of the building and the rooftop hot tub were our favorite aspects. We already told multiple people how cool it was.
Top guest favourite

Hotel room in St. Louis
4.96 out of 5 average rating, 54 reviewsNapoleon's Retreat - Lafayette Room
MaddieRating, 5 stars2 weeks ago
Beautiful Airbnb! It was in the perfect location for us. We wanted to be close to the Union Station and the Arch. Matthew was always quick with his responses and very helpful. I’d stay here again!
Guest favourite

Hotel room in St. Louis
4.97 out of 5 average rating, 31 reviewsLuxury Retreat, Hot Tub,En-Suite Bath, Location+
LatonyaRating, 5 stars2 months ago
It was worth it and then some Jess was amazing. Her mother was amazing. Very helpful. I hope to come back. Matter fact I will be coming back. I think I’m gonna celebrate my own birthday there.

Hotel room in Saint Charles
4.69 out of 5 average rating, 228 reviews1st Capitol Mansion Boutique Hotel - Suite 301
ShianneRating, 5 stars3 weeks ago
It was nice for our little weekend stay and was close to downtown! Very quiet building and area.
Top guest favourite

Hotel room in St. Louis
5 out of 5 average rating, 12 reviewsLuxury Retreat, Hot Tub,En-Suite Bath, Location+
AkshayRating, 5 stars2 months ago
This is a hidden gem that is maintained exceptionally well. The check in was smooth and the owners are very friendly. Only time we saw them was when we checked in and they gave us a tour of the place. The entire property is squeaky clean and provides every comfort offered in a five star hotel. I've stayed in many five star hotels across the world (Ritz Carlton, Four Seasons, Waldorf Astoria) and this is arguably better than those places given the unique experience it offers and the character of this place. I would definitely recommend this to anyone looking for a unique experience in St. Louis. It is also located in close proximity to a lot of local attractions.
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- Busch Stadium
- Enterprise Center
- Six Flags St. Louis
- Saint Louis Zoo
- Central West End
- Gateway Arch National Park
- Missouri Botanical Garden
- City Museum
- St. Louis Aquarium at Union Station
- Saint Louis Science Center
- Castlewood State Park
- Hidden Valley Ski Resort
- Meramec State Park
- Missouri History Museum
- Pere Marquette State Park
- Cuivre River State Park
- Adventure Valley Zipline Tours and Paintball Park
- Raging Rivers WaterPark
- The Winery at Aerie's Resort
- Cathedral Basilica of Saint Louis
- Grafton Winery the Vineyards
- St. Louis Country Club
- Boone Valley Golf Club
- Old Warson Country Club