Hotel vacation rentals in St. Charles County

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Top-rated hotels in St. Charles County

Guests agree: these hotels are highly rated for location, cleanliness, and more.

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Hotel room in Chesterfield

4.5 out of 5 average rating, 18 reviews

Pet-friendly Suite w/ Own Kitchen and Free Parking

Situated in the suburban city of Chesterfield, this hotel offers an ideal location for exploring the area's attractions and provides an excellent base for visits to St. Louis. It is well-placed for shopping breaks, with Chesterfield Malls and St. Louis Premium Outlets nearby. At the same time, those seeking active pursuits may enjoy the Hidden Valley Ski Resort. Several family day trip options, including the Magic House, Missouri Botanical Garden, and Six Flags St. Louis, can be found nearby.

Hotel room in Alton

4.94 out of 5 average rating, 36 reviews

Three Bedroom River View Guest House

An escape from the ordinary in our River view guest house. On bottom level is an art glass shop offering classes in stained , fused, and mosaic art glass you may partake in at an additional cost. Bicycle built for two available for cycling the national scenic byway. Walk to shops, casino, restaurants, breweries, and concerts. Cruise ship dock is 1/2 mile away. Extend your stay before or after to enjoy taking a stained glass class offered in our shop below as a souvenir of your trip.

Hotel room in Brentwood

Give Yourself a Fancy Vacation! Superb Amenities!

By staying at our property, you can make the most of your trip, whether it's for work or pleasure. We are conveniently located near renowned destinations including Hanley Park, the St. Louis Children's Aquarium, and Oak Tree Park in the Brentwood neighborhood. We are close to Whole Foods Market, Applegate's Deli, and Camille's Sidewalk Cafe, among other well-known restaurants. You can grab a free breakfast in the morning and get a head start on your day. Enjoy the free parking and Wi-Fi.

Hotel room in Brentwood

The Best of Suite Living! Ideal for Work & Leisure

Superhost

Hotel room in Saint Louis

4.85 out of 5 average rating, 726 reviews

The Maple Room Queen Bed at BnB in CWE!

A Lovely room in a historical St. Louis home! The Blue Spruce Room is on the 2nd floor, and has a recently renovated and beautiful bathroom complete with a walk-in rain shower right next to it. The room has a desk, chair, lamp, table, Amazon Fire TV with basically every major streaming App, newly installed hardwood floors, and a Queen sized-bed. The room has two large windows for plenty of natural light with heavy blinds for sleeping in! Full use of the kitchen upstairs is available!

Guest favourite

Hotel room in St. Louis

4.87 out of 5 average rating, 662 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

Hotel room in St. Louis

4.78 out of 5 average rating, 9 reviews

The West End - Futon with Queen

The West End is located in the St. Louis Central West End Neighborhood! Great amenities are: - Fast and stable fiber internet connection - Free parking spot, INCREDIBLE in downtown Central West End (other hotels charge $15-20/day!) - Communal kitchen with 2 sets of range, ovens, fridges, microwaves, and dishwashers. - Complimentary coffee - Great patio space with seating and a gas grill - Complimentary Netflix, Hulu, Disney+, and ESPN+, where available and local TV channel

Hotel room in St. Louis

5 out of 5 average rating, 3 reviews

Unique Warehouse Penthouse

Spacious & intriguing warehouse penthouse loft for large group stay. 2000 sq. ft. suite sleeps 8-20+ guests. Open studio-style sleeping with 1 private bedroom offering a king-size bed. Located on the top (3rd) floor. Great sunset views. Large shared game room w/ full additional kitchen, additional bathroom, tv's, pool table,ping pong, and darts! Commercial keypad entry locks & security cameras. Free secure parking.

Superhost

Private room in Ferguson

5 out of 5 average rating, 4 reviews

Haunted 1905 Victorian home

We offer a unique opportunity to sleep in a 100 year old haunted house. There are two known spirits that have been heard and seen on the premises. The bedroom is a simple affair on the third floor, but the center of paranormal activity. For an additional fee, guests can participate in casting a spell of their choice or receive a tarot reading in an authentic witch apothecary.

Hotel room in Saint Charles

4.8 out of 5 average rating, 148 reviews

1st Capital Mansion Boutique Hotel - Suite 302

First Capitol Mansion - The Louis Blanchette second floor The Mansion Make the most of your St. Charles experience with a stay in the historic First Capitol Mansion, right in the heart of the city. This completely renovated home was thoughtfully done, keeping in much of the original brilliant architecture, while bringing in bright light, gathering spaces and modern comfort.

Hotel room in St. Louis

3.9 out of 5 average rating, 10 reviews

Spacious Suites to accommodate all your needs

Keep your routine intact when you travel to St. Louis for extended periods of time. Craigshire Suites St. Louis Westport Plaza hotel is near St. Louis Airport (STL) and a great choice for travel and relocation needs. Our clean and accommodating guest rooms were designed with your comfort in mind. Each of our spacious suites comes with a full kitchen and private entry.

Guest favourite

Hotel room in Saint Louis

4.89 out of 5 average rating, 852 reviews

King Redwood Bedroom at BnB in CWE!

This is the largest of the rooms we have at our CWE BnB - an historic house in St. Louis' premier neighborhood. It has one King sized bed, a pullout sleeper sofa, two back-to-back 45" 4K Smart TVs with Rokus, and bathroom and kitchen space shared with guests of other rooms on this floor. Within a short walk of the basilica and many bars and restaurants in the CWE!