Vacation rentals in East Prairie

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in East Prairie

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favourite
Home in Golconda
4.93 out of 5 average rating, 147 reviews

Dawns Retreat

No pets. Dawns Retreat is a farm house remodeled in 2023 with a rustic feel that offers a cozy relaxing stay. WiFi 3 smart tv’s 1 Queen 1 full Gas fireplace Gas grill Open fire grill Firewood Electricity at fire pit Plenty of parking Garage Deer hanging station. Heart of Shawnee National Forest. Golconda 10min. Eddyville 15min Harrisburg 35min Paducah KY 35min Note: the field around the yard is private property. Things to do in the area Horseback riding Hiking Boating Fishing Huntin

Guest favourite
A single-story home is presented, featuring a white exterior with black shutters and a welcoming front door. A covered porch with hanging lights is visible, framed by two potted plants. The lawn is well-maintained, surrounded by trees under a clear blue sky.
Tiny homes in Bloomfield
4.93 out of 5 average rating, 149 reviews

1-bedroom tiny home located in historic Bloomfield

Kick back and relax in this calm and stylish space located minutes from the Missouri Veterans Cemetery and The Stars and Stripes Muesum and Library. 1bdrm/1bath comfortably sleeps 2 and is furnished with everything you need. Inside you will find all new appliances, bedding, and linens. Circle drive with parking. No smoking or pets allowed. Local restaurants include Las Brasis and Elderland. Or try out locally owned businesses just 6.5 miles drive to Dexter such as Hickory Log and Dexter BBQ!

Guest favourite
Dome in Brookport
4.96 out of 5 average rating, 24 reviews

Glamping Double Domes on Private Lake & Hot Tub!

Adventure meets comfort at the Space Cowboy Lake Domes — the ultimate glamping experience where rustic frontier charm collides with sleek modern design. This unique double-dome retreat features a full kitchen, bathroom, and space for up to four guests across two connected domes — one with a cozy living area and sleeper sofa, the other with a private queen bedroom. Step outside to your expansive lakefront deck with a hot tub, fire pit, grill, outdoor shower, and private lake access and kayaks.

Top guest favourite
The custom-built treehouse is elevated on stilts, surrounded by greenery. A spacious deck features a railing, offering access to the entrance. Steps lead to the ground below, while large glass doors enhance the connection to nature.
Treehouse in Cape Girardeau
5 out of 5 average rating, 202 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Top guest favourite
A modern farmhouse is depicted at sunset, featuring a welcoming entrance with a covered porch. A stone pathway leads to the front door, bordered by a grassy lawn that extends to fields and trees in the background.
Barn in Cape Girardeau
4.95 out of 5 average rating, 260 reviews

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Guest favourite
A cozy living area features exposed brick walls complemented by large windows allowing natural light. Two blue sofas sit opposite a wooden coffee table, which holds a small plant. A dining table is visible in the background, creating a welcoming space for relaxation or socializing.
Condo in Paducah
4.95 out of 5 average rating, 707 reviews

Cozy studio in The Foxbriar - Downtown

Home of the former Foxbriar Inn, this condo is located inside a beautiful historic building. This space is great for your weekend away or a longer term stay. Exposed brick and high ceilings make it a charming and cozy experience. Enjoy the perks of walking to lots of great restaurants, specialty shopping and boutiques. We are just seconds from a beautiful stroll along the River. Bakery and coffee shop underneath. Enjoy brunch on the weekends or a sweet treat anytime in the week.

Top guest favourite
Guesthouse in Cape Girardeau
4.94 out of 5 average rating, 588 reviews

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

Top guest favourite
The exterior of a geodesic dome is showcased on a wooden deck, featuring large windows that offer views of the surroundings. A hot tub is positioned nearby, accompanied by stylish outdoor seating that invites relaxation amid the natural landscape.
Dome in Simpson
4.99 out of 5 average rating, 102 reviews

Glamping Dome · Hot Tub, Fire Pit & Forest Views

One of Illinois' most-favorited Airbnb listings — and once you arrive, you'll understand why. Soak in your private hot tub under a canopy of stars, wake up to panoramic forest views through floor-to-ceiling dome windows, then explore 8 acres of total seclusion. King bed, full kitchen, washer/dryer, fire pit, and charcoal grill all included. Intentionally TV-free — the night sky is the entertainment. Minutes from Shawnee National Forest trails and wine country.

Top guest favourite
A well-appointed kitchen features a double basin sink beneath a bright window. Light wooden walls complement white cabinetry and a dark countertop. A small plant adds a touch of greenery, and a kitchen towel hangs from the drawer, highlighting the functional design.
Cottage in Martin
4.93 out of 5 average rating, 252 reviews

Country Cottage Home on 2 Acres Close to UTM

The whole group will enjoy easy access to everything from this centrally located place. Just down the road from the local medical businesses including the hospital and Cane Creek rehabilitation center , UTM and local shops. Quite and safe neighborhood with plenty of parking. One king bed in bedroom along with a couch and air mattresses. Extra linens included. Plenty of towels. Washer/dryer. Refrigerator,Stove,Microwave.

Top guest favourite
Home in New Madrid
5 out of 5 average rating, 10 reviews

Family Home near the MS River with a toy Room

The whole group will enjoy easy access to everything from this centrally located place. 3 blocks from the New Madrid boat ramp / levee. Less than 5 miles from HWY 55. Large family style home - on the first level - living room, dining room, kitchen, laundry room, guest bathroom, main bedroom and main bathroom. The upstairs has 2 bedrooms and a toy room with another full bathroom upstairs.

Top guest favourite
Home in Clinton
4.99 out of 5 average rating, 200 reviews

The Peery House at Springhill Farms

The Peery House is our family home-place, built circa 1900, transformed into a quaint Airbnb. It is located on our farm, Springhill Family Farms in Western KY and is a great place for someone looking to get away from the busyness of life, looking for rest and relaxation or just looking for a unique, little farmhouse while passing through the area.

Top guest favourite
Home in Hornbeak
4.99 out of 5 average rating, 148 reviews

THE DREAMCATCHER

Beautiful brick home with lake view and access to Reelfoot Lake (no ramp), paved drive with ample parking for boat / trailer, back deck with table and chairs, open space kitchen and den, perfect for group fishing trip, hunting trip, or just sight seeing, (area known for its large population of eagles), quiet neighborhood, peaceful place to stay.

Popular amenities for East Prairie vacation rentals