Vacation rentals in East Syracuse

Cozy 3BR Home ~ 12 Minutes from NYS Fairgrounds

This cozy, stylish home boasts modern amenities and historic charm. Originally a two-bed/one-bath 1922 bungalow, we've added a master bedroom suite that feels like an escape to a spa. The freshly remodeled three-bedroom, two-bathroom home is perfect for an extended stay with family, and just right for a weekend away with friends. Within walking distance to coffee, restaurants, and cute shops. A quick, ten-minute drive to Downtown Syracuse, Upstate University Hospital, and Syracuse University.

Charlie's Place

Our place is located in a quiet and safe neighborhood just off the interstate - 10 minutes from Syracuse University, LeMoyne College, hospitals and downtown. It is just minutes away from Starbucks, Panera's, Wegmans and numerous other restaurants and shopping facilities. It is also very close to the Erie Canal trail for walking, jogging or biking. We have chosen to go with an Adirondack theme with our decor. We live just across the street and you will enjoy total privacy when you stay.

Elegant 2BR w/ Custom Wood Charm

Welcome to our all-new, freshly renovated 2-bedroom retreat in Syracuse’s West Side! Conveniently located near everything Syracuse has to offer—Destiny USA, Downtown, Syracuse University, Tipp Hill, the NY State Fair, restaurants, and nightlife. This peaceful upstairs unit features brand-new steel appliances, spacious bedrooms, and a cozy living room. The handcrafted wood kitchen boasts a stunning wood ceiling and a center island. Enjoy a serene, private stay with all the comforts of home!

Gracious 1920s Georgian close to hosp & colleges

The whole group will enjoy easy access to everything from this spacious, centrally located home. Close to SU, LeMoyne, ESF, St Joseph’s hospital, Crouse & Upstate. Enjoy the large kitchen and separate dining room, and relax in the living room. You can look forward to a great nights sleep in our 2- king beds in our master suites, or a full in the guest room. If you don’t require full use of the house, please let us know and we can adjust the cleaning fee prior to your booking.

Entire Modern Cozy 2BR Apt mins SU LeMoyne DT

Retro-inspired retreat with bold design, natural light, and a dedicated workspace—ideal for remote work or weekend stays. Conveniently located just minutes from key local destinations. Nearby Syracuse University & JMA Wireless Dome – ~2.5 miles / ~7 mins Le Moyne College – ~1.5 miles / ~5 mins Downtown -~3.4 miles / ~10 mins SUNY Upstate Medical University – ~3 miles / ~8 mins CNY Fertility Syracuse – ~3.4 miles / ~13 mins Syr Hancock Int'l Airport – ~4.2 miles / ~15 mins

Enormous Convenient Home in Clean, Quiet Syracuse

Welcome to your perfect getaway in Syracuse, New York! Our expansive home offers a blend of comfort, and charm, making it an ideal choice for both short and long-term stays. Whether you're in town for a family vacation, a work trip, or an extended stay, this home caters to all your needs. Its convenient location provides easy access to Syracuse's local attractions, dining, and entertainment. Experience comfort like never before in a place that feels like home!

Affordable private basement apartment

My place is 10 min from Syracuse University, Upstate University hospital, Crouse Irving hospital, 5 min from LeMoyne College, 8 min from downtown Syracuse and St. Joeseph's Health hospital, 16 min from Green Lakes State Park... You’ll love my place because of the quaintness, the quiet and the proximity to what Syracuse has to offer. My place is good for couples, small families, solo adventurers, people with animals, and business travelers.

Opie's Arcade and Movie Room, Sleeps 12

OPIES ARCADE WELCOMES YOU! Go back in time and immerse yourself back to the 90s. Let your family experience the lights, sound, and fun of a traditional 90s arcade. Enjoy family movie night in a blockbuster theater. Newly renovated space with two bathrooms and 5 bedrooms. Fully fenced outdoor area to allow kids and pets to run freely Enjoy your evening besides your outdoor fire pit (note you will need to bring your own firewood)

Syracuse Cozy Home Near SU & Destiny USA, Wi-Fi

Syracuse cozy, private, clean, and comfortable guesthouse in the Eastwood neighborhood. Ideally located just minutes from Syracuse University, downtown Syracuse, major hospitals, and top attractions. Enjoy fast WiFi, a fully equipped kitchen, free parking, self check-in, and complete privacy—perfect for business travelers, medical stays, families, and extended stays. A peaceful and convenient home away from home in Syracuse.

Newly renovated & modern 2-bedroom apartment

Enjoy a stylish stay at this newly renovated apartment. Minutes from downtown, Syracuse University, Destiny USA, and top hospitals. This thoughtfully designed space features two bedrooms with comfy queen beds, a dedicated workspace, and a fully equipped kitchen. Perfect for business travelers, University visits, or a weekend getaway. Just 12 minutes from the airport, with easy access to dining, shopping and entertainment.

★ Quiet Gem minutes to SU, Downtown & Westcott! ★

Centrally located and cozy gem in the quiet, safe, and friendly Meadowbrook neighborhood. Minutes away from the center of Syracuse University, the Carrier Dome, Le Moyne College, and shopping centers. Just 4 minutes to the Westcott Theater by car and a pocket of unique restaurants. My home features everything you need for a comfortable stay in Syracuse. I'd love to have you come to enjoy the beautiful area!

Charming Getaway | Patio | Great Location | 6+

Take it easy at this unique and tranquil getaway. Whimsical retreat perfect for all families! Cozy 3 bedroom home (sleeps 6) with fully stocked kitchen, WiFi, smart TVs, washer/dryer, balcony, and a charming patio with fire pit and grill. Quiet yet close to restaurants, shops, and top attractions like Green Lakes. Ideal for relaxing, exploring, and making memories.