Vacation rentals in Isola

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Top-rated vacation rentals in Isola

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favourite

A cozy seating area is presented with two light blue chairs and a matching chair, all adorned with decorative pillows. A small, circular table sits at the center, and a large area rug enhances the space. Natural light enters through nearby windows.

Home in Greenville

🌺Lillie's Manor🌺

Lillie’s Manor is a spacious 3 bedroom 2 full bathroom home, consisting of 2 full beds (downstairs), 2 queen beds (upstairs), 2 sofa sleepers (1 full, 1 queen both downstairs). There is also 2 folding beds. Spacious family room w/plenty of seating space for guests. 4 smart TVs with accessible WiFi and DirecTV in the family room and kitchen areas. Alarm system available for guests & private parking at the rear. Check in instructions will be sent 1-2 days prior to check in. 🚭No smoking 🚫No Pets

4.87 out of 5 average rating, 101 reviews

Top guest favourite

Guesthouse in Drew

Cozy Country Pool House Retreat

Our cozy pool house retreat is located in the Heart of the Mississippi Delta on a secluded 40 acre country setting surrounded by woods and a beautiful bayou full of cypress trees. It's located just off Drew-Merigold Road away from everyone, with no neighbors!! Yet close to everything - only 5 minutes to Drew, 10 minutes to Ruleville, 15 minutes to Cleveland, and 30 minutes to Clarksdale. We are only 10 minutes to McCarty's Pottery in Merigold, and 15 minutes to Peter's Pottery In Mound Bayou.

5.0 out of 5 average rating, 29 reviews

Top guest favourite

The exterior showcases a single-story house with a brick facade and a blue metal roof. Lush greenery and flowering plants are arranged along the front, complementing the palm tree near the entrance. A driveway leads up to an overhang and parked vehicle, with a lawn stretching across the front.

Home in Leland

“Pink on the Creek”Guest House

FREE BREAKFAST, SNACKS & ICE CREAM FOR YOU THERE. NO CLEANING FEE ! Possible flexible, cancellation VERY SAFE AREA IN THE HEART OF THE MISSISSIPPI DELTA BLUES🎸 Extra charge per person per night after 5 Max is 7. Better than just a motel room. Antique & modern, though greatly cared for, shows age in some places, loving wear, quaint aging & charming patina both inside and outside, is super clean/sanitized. people love it. Very Affordable for a whole house in this area. A pillow selection

4.98 out of 5 average rating, 154 reviews

Guest favourite

Home in Hollandale

X Marks the Spot.

Relax with the whole family at X Marks the Spot. Home is completely remodeled. Beautiful Kitchen is waiting for you to prepare a Home cooked meal. Home can sleep up to seven people with 2 Queen Beds, 2 Twin Beds and One rollaway Bed. Onsite laundry room. Nice size TV in the front room to watch, along with TVs in each of the Bedrooms. Come and stay awhile and enjoy this beautiful home. Don't worry about coming home late, this house has Dusk to Dawn automatic recessed lighting.

5.0 out of 5 average rating, 29 reviews

Guest favourite

A cabin on stilts is set amidst a grassy area surrounded by trees. The structure features a front porch with railing and a staircase leading up to the entrance. Large windows are present, allowing natural light to enter the space.

Cabin in Sharkey County

Deltas Poor Man Hunting Camp

“Welcome to the heart of the Mississippi Delta, where rugged wilderness meets some of the best public land deer hunting the state has to offer. At our camp, you’ll experience prime hunting grounds, with towering hardwoods, thick brush, and sprawling fields that draw in trophy whitetails. Whether you’re stalking bucks in the dense timber or watching the sunrise over the Delta’s vast wetlands, this is where serious hunters come to experience the thrill of a true wild hunt.

4.93 out of 5 average rating, 15 reviews

Guest favourite

A charming cottage is set in a lush green landscape, featuring a wooden porch with seating. The exterior showcases light wood siding and large windows that allow natural light to fill the space. Surrounding trees create a serene atmosphere.

Farm stay in Shaw

Peacock in the Delta/ Mississippi Delta Cottage

WELCOME TO PEACOCK-A charming cottage set on a 1,700 acre bucolic farm in the middle of the Mississippi Delta. Private and secure. All guests are welcome to use the swimming pool (June 1-October 2), tennis court, horseback riding, walking trails. We are perfectly located in the middle of the Delta, with close proximity to most blues trail sites. We are also within easy driving distance to most restaurants in the Delta. Need more space? See https://abnb.me/ERkRyvI0rjb

4.94 out of 5 average rating, 363 reviews

Guest favourite

A two-story lake cottage is shown, featuring a wood and stone exterior. The structure is elevated on stilts, and large windows reflect the surrounding greenery. A grassy area extends in front, with a circular driveway visible and steps leading to a second-floor porch.

Cottage in Greenville

Beautiful four bedroom lake cottage!

Enjoy the most beautiful sunsets in the delta from the porch of this peaceful lake cottage located on beautiful Lake Ferguson in Greenville, MS. Though just a few minutes from all the conveniences of the town, this serene cottage allows you to feel miles and miles away from the hustle and bustle. Please note: *No Parties or Events-Strictly Enforced! *Only people listed on the reservation should be at the property. *The max occupants at this house 8.

4.93 out of 5 average rating, 112 reviews

Guest favourite

The kitchen features white cabinetry and a modern stainless steel refrigerator. A hexagonal tile backsplash complements the granite countertops. Natural light filters through a window above the sink, illuminating the space. Appliances include a microwave and a coffee maker, situated on the countertop.

Home in Greenwood

The Quiet Haus

Welcome to The Quiet Haus, a spacious 4-bedroom, 2-bathroom retreat in a quiet, family-friendly neighborhood. Perfect for families, friends, business travelers, and coworkers, the home offers comfort, space, and convenience just minutes from town. Whether you’re visiting for business, a weekend getaway, special occasion, or extended stay, The Quiet Haus provides a peaceful and welcoming place to rest, recharge, and enjoy your time away from home.

5.0 out of 5 average rating, 21 reviews

Top guest favourite

The exterior of the cabin is displayed, featuring a sturdy wooden porch supported by steps leading to the front door. Large windows are framed in light wood, allowing natural light. Gravel surrounds the structure, and greenery is visible in the background along with boats at a nearby pier.

Cabin in Yazoo City

The Lazy Wolf

Welcome to The Lazy Wolf! This family-friendly 3-bedroom, 2-bath cabin is perfect for weekend getaways or long, relaxing stays. Enjoy lake views from the screened-in patio, ideal for morning coffee or evening gatherings. The back yard offers, a grill, swing set, fire pit and pier. The property is located near a public boat ramp. Whether you’re looking to unwind or make memories on the water, this cabin has everything you need for a perfect stay.

5.0 out of 5 average rating, 17 reviews

Superhost

The two-story cabin is illuminated at night, showcasing warm lighting from its large windows. Outdoor seating is arranged around a fire pit, with string lights enhancing the inviting ambiance. A spacious porch with steps leads up to the cabin entrance.

Cabin in Yazoo City

Cypress Cabin at Wolf Lake

Relax with the whole family or a group of friends, enjoying beautiful sunsets @ Wolf Lake. Make memories around the fire pit, cooking on the grill, spending time on the water skiing or fishing. There is so much to do at Wolf Lake, but the best part is relaxation with your family & friends. 3-bedroom cabin with Wi-Fi and large, big screen tv to enjoy the game or watch a movie after a long day on the lake.

4.96 out of 5 average rating, 27 reviews

Guest favourite

The spacious bedroom features a large bed with an ornate headboard and coordinating furnishings. A wooden dresser is positioned against a wall, while two comfortable leather chairs and an end table create a cozy seating area. Natural light enters through a nearby window.

Home in Cleveland

Comfortable Spacious Home Sleeps Up To 16 w/pool

This is a spacious, 2-story home with 7 bedrooms, 4 baths, family room, large kitchen, large dining room, and in-ground pool. The property is 5 to 10 minutes from DSU, Grammy Museum, and restaurants. EVENTS ARE NOT ALLOWED! Guests cannot have class reunions, family reunions, weddings, receptions, large gatherings before or after funerals, etc.). Property has perimeter cameras.

4.82 out of 5 average rating, 146 reviews

Top guest favourite

A cozy bedroom features a queen-sized bed with neutral-toned bedding and decorative pillows. Beside the bed, a lamp provides soft illumination. Natural light filters through a set of slatted shutters, and hardwood flooring adds warmth to the space.

Apartment in Greenwood

Spacious one bedroom Delta apartment

Mississippi Delta hospitality in a spacious and practical apartment. You will be located within about a 6 block walking distance of downtown Greenwood, the Yazoo River Trails, and many homes from The Help tour. The neighborhood is quaint and quiet. This apartment is 800 sq ft with a queen sized bed, full kitchen, full bath, and comfortable den with open living space.

4.99 out of 5 average rating, 167 reviews