
Hotel vacation rentals in Mission Bay, San Diego
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Top-rated hotels in Mission Bay, San Diego
Guests agree: these hotels are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay, San Diego hotels
Family-friendly hotels

wavecrest del mar beach resort ocean view studio

Coronado Beach Resort

Hobbit

Private Room in Hostel by the Beach, 2 Double Beds

Luxury Villa #6550 at Omni's La Costa Resort & Spa

Villa L'Auberge Del Mar Resort 8/24-9/7 2025 ONLY

Gaslamp 2BdRm - w Parking & 4 Beds #204

Greely Gaslamp - Loft w Parking & 3 Beds #302
Hotels with a pool

Recently reno’d escape near the Gaslamp Quarter

Stylish San Diego downtown Suite

Iconic Resort in San Diego

San Diego Stay w/ Pool + Free Airport Shuttle

At the heart of Gaslamp District

Hike Cowles Mountain Easy + Free Breakfast. Pool

1-Bedroom Hotel Suite - 2 beds

Private Upstairs Apartment
Hotels with a patio

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Charming 1 bedroom resort steps away from beach

Comic-Con 2025: Spacious King Suite + Sofa Bed

1 Bed in a 6 Bed Dorm near San Diego Airport

Nice Property, stay right in SD!
Quick stats about hotel rentals in Mission Bay, San Diego
Total rentals
130 properties
Nightly prices starting at
$275 CAD before taxes and fees
Total number of reviews
200 reviews
Family-friendly rentals
30 properties are a good fit for families
Pet-friendly rentals
80 properties allow pets
Rentals with a pool
130 properties have a pool
Destinations to explore
- Townhouse rentals Mission Bay
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- Rentals with breakfast Mission Bay
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- Pet-friendly rentals Mission Bay
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- Rentals with a patio Mission Bay
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- Rentals with an EV charger Mission Bay
- Beachfront rentals Mission Bay
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- Rentals with a firepit Mission Bay
- Rentals with a hot tub Mission Bay
- Rentals with a fireplace Mission Bay
- Rentals with pools Mission Bay
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- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Pacific Beach
- Tijuana Beach
- Coronado Beach
- San Clemente State Beach
- SeaWorld San Diego
- Oceanside Harbor
- LEGOLAND California
- San Onofre Beach
- University of California San Diego
- Coronado Shores Beach
- San Diego Zoo Safari Park
- Balboa Park
- Black's Beach
- Trestles Beach
- Surf Beach
- Belmont Park
- Pechanga Resort Casino
- Sesame Place San Diego
- Liberty Station
- Moonlight Beach
- Playas Los Buenos