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Vacation rentals in Santa Clara

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Top-rated vacation rentals in Santa Clara

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Home in Gamboa

4.86 out of 5 average rating, 88 reviews

BirdHouse@ Gamboa Panamá Canal

Explore the wonders of the Panama rainforest and return to our magical tropical home! This unique house and pool is a wonderful place to escape the hustle of Panama City, celebrate nature, and enjoy family and friends. Gamboa is a safe, quiet town embedded in the Soberania National Park; it is the entry point to Pipeline Road, some of the best birding in the world. Or take leave of the forest and watch manatee, while fishing for peacock bass in Gatun Lake or paddling kayaks up the Chagres River.

Aug. 12 – 19

$505 CAD per night

Guest favourite

Guesthouse in Gamboa

4.95 out of 5 average rating, 56 reviews

Gamboa Toucan Apartment casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Mar. 6 – 13

$122 CAD per night

Guest favourite

Home in Costa Esmeralda

4.96 out of 5 average rating, 106 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sand! Come relax with the whole family at this piece of paradise. Majestic Sand is located in a private beach community in Costa Esmeralda, San Carlos District, Panama. It is located a few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, Santa Clara and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool with multiple hammocks with views of amazing palm trees.

Oct. 11 – 18

$260 CAD per night

Earth homes in El Cope, Penonome

4.91 out of 5 average rating, 146 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Dec. 15 – 22

$303 CAD per night

Guest favourite

Guesthouse in La Ermita de San Carlos

4.97 out of 5 average rating, 107 reviews

Sky Cabin/Beaches/Pool/Surf/Digital Nomads

The Sky Cabin is part of 5 cabins “A Piece of Paradise” With registration in the Panamanian Tourism Authority Bureau. ✸ Ideal for a couple or a single person ✸ Outdoor dining area and kitchen ✸ Spacious terrace with a hammock ✸ Very quiet neighborhood ✸ Private and public transportation available, just ask and we will help you ✸ 7-10 minutes, by car, from Playa La Ermita and 10 minutes from Playa El Palmar (great spot for surfing) ✸ Breakfast for an additional $7.00, for each guest.

Jun. 7 – 14

$52 CAD per night

Guest favourite

Loft in Panamá

4.91 out of 5 average rating, 179 reviews

Amazing Loft with the Best view of Casco viejo!

Hermoso loft ubicado en el centro de Casco Antiguo, la zona más turística de Panamá. Ven, disfruta y relájate en este impresionante loft, con una vista increíble de la Catedral de Panamá. Puedes visitar museos, bares, restaurantes e iglesias ubicados a tan solo unos cuantos metros de distancia. Beatiful Loft located in the center of Casco Antiguo, Panama´s most turistic location. Come, enjoy and relax at this amazing loft, with amazing view to Panama´s Cathedral.

Sep. 9 – 16

$152 CAD per night

Guest favourite

Home in Taboga Island

4.96 out of 5 average rating, 141 reviews

Casa Rosie - Taboga dream home

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Jul. 27 – Aug. 3

$336 CAD per night

Guest favourite

Apartment in Panamá Oeste

4.86 out of 5 average rating, 29 reviews

New and beautiful apartment in Panama Pacifico

Remodeled apartment located in a very quiet place with rural area surrounded by a rich and lush nature just 15 minutes from the city. It is fully equipped, thinking about comfort and style so that the guest has a comfortable and unforgettable stay. It has a fully equipped kitchenette, laundry room, dressing room, large bed bed, and great couch. With access to the delicious pool and around it ecological trails for walking, relaxing and disconnecting.

Oct. 11 – 18

$95 CAD per night

Guest favourite

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 196 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Apr. 29 – May 6

$434 CAD per night

Guest favourite

Home in El Valle de Antón

4.93 out of 5 average rating, 118 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Jul. 16 – 23

$163 CAD per night

Guest favourite

Guest suite in Gamboa

4.95 out of 5 average rating, 79 reviews

Beautiful annex in the middle of Gamboa Rainforest

Enjoy nature without leaving home in this historic town located in Parque Soberania and on the shores of the Panama Canal. Just 40 minutes from the stressful capital, you can relax walking, bird watching in Pipeline, kayaking, fishing on the Chagres River, on the island of monkeys, visiting an indigenous town or watching sloths. Also bike lovers will find their place. At night, take a relaxing bath and sleep peacefully.

Jan. 29 – Feb. 5

$105 CAD per night

Guest favourite

Loft in Panamá

4.95 out of 5 average rating, 55 reviews

Canal Loft

Apartamento en 1er Piso, ideal para parejas amantes del buen gusto, tranquilidad y confort. Cerca del apartamento hay senderos hacia el el Canal de Panamá, colinas y selva. Apartment on the 1st Floor, ideal for couples who love good taste, tranquility and comfort. Near the apartment there are trails to the Panama Canal, hills and jungle.

May 8 – 15

$97 CAD per night

Vacation rentals for every style

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Popular amenities for Santa Clara vacation rentals

Free parking on premises

Air conditioning

Other great vacation rentals in Santa Clara

Guest favourite

Cabin in Chicá

4.93 out of 5 average rating, 59 reviews

Cabaña Horizonte by Casa Amaya

Nov. 22 – 29

$106 CAD per night

Guest favourite

Home in Panamá Oeste

4.97 out of 5 average rating, 64 reviews

AX8 beach house near the city!

Sep. 1 – 8

$161 CAD per night

Guest favourite

Guesthouse in El Valle de Antón

5.0 out of 5 average rating, 32 reviews

Spacious Casita with Bamboo View

Jan. 19 – 26

$123 CAD per night

Guest favourite

Cottage in Panamá

4.95 out of 5 average rating, 21 reviews

Modern House in Altos de Cerro Azul with 2 rooms

Jul. 14 – 21

$197 CAD per night

Guest favourite

Condo in Maria Chiquita

5.0 out of 5 average rating, 19 reviews

Playa Escondida Lux Beachfront Haven:Oceanview Apt

Sep. 22 – 29

$700 CAD per night

Guest favourite

Apartment in El Chirú

4.94 out of 5 average rating, 33 reviews

Cute Loft Buenaventura @ Plaza del Hotel

Aug. 27 – Sep. 3

$210 CAD per night

Guest favourite

Condo in Nueva Gorgona

5.0 out of 5 average rating, 16 reviews

20th Flr Beachfront Nueva Gorgona, Panama 2/3 unit

Aug. 9 – 16

$196 CAD per night

Guest favourite

Villa in Portobelo

5.0 out of 5 average rating, 42 reviews

Entire Villa with pool in front of beach!

Apr. 19 – 26

$346 CAD per night

Destinations to explore