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Vacation rentals in Panama City

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Top-rated vacation rentals in Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favourite
Apartment in Obarrio
4.96 out of 5 average rating, 25 reviews

Modern apartment in the heart of Obarrio

This apartment stands out for its prime location in Obarrio, with a modern and cozy design. Located on the 14th floor, it offers a spectacular view, its decoration in neutral tones conveys serenity. The comfort of having two bathrooms makes it unique. Ideal for travelers looking for tranquility and functionality. Located within walking distance of Calle 50 and the iconic El Tornillo building. You're surrounded by casinos, hotels, and restaurants. Safe area to walk and enjoy the city.

Top guest favourite
A spacious living room features a comfortable brown sofa and an armchair beside a decorative coffee table. Natural light enters through large glass doors draped with sheer curtains, illuminating the warm wood floors and elegant decor.
Apartment in Panama City
5 out of 5 average rating, 86 reviews

Luxury Mid-Century Apartment In Casco Viejo

Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

Top guest favourite
A communal rooftop space is revealed, showcasing several white-accented chairs and small tables arranged amidst potted plants. The backdrop features a panoramic view of the Panama City skyline against a clear blue sky.
Apartment in Santa Ana
5 out of 5 average rating, 57 reviews

Tropicool Loft w/rooftop steps from Casco

This historic 1941 loft is located at the entrance of Casco Viejo where you’re steps from the fish market and all the cool cafés, rooftops, and trendy restaurants that make up the neighborhood. Fully equipped kitchen, washer/dryer combo, 1.5 bath, bedroom on 2nd floor, 2 balconies + communal rooftop, projector w/Netflix, fast internet, and great AC. You’re also directly in front of the Cinta Costera park for running, biking, tennis courts. Near local airport for flights to Bocas!

Top guest favourite
A modern living area features a large wave mural that enhances the space's vibrant decor. Comfortable seating arrangements include a sleek white sofa and a pair of stylish armchairs. A glass coffee table is centered among the furnishings, with tastefully arranged decorative accents.
Apartment in Panamá
4.93 out of 5 average rating, 284 reviews

Modern apt ocean view in heart of Panamá yoo tower

Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Top guest favourite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Apartment in Panamá
4.98 out of 5 average rating, 161 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Top guest favourite
Apartment in Panama City
4.97 out of 5 average rating, 93 reviews

Amazing loft with an iconic view of Casco Viejo

Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Top guest favourite
Apartment in Panamá
5 out of 5 average rating, 10 reviews

Private parking & rooftop | Studio Casco Center

This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Guest favourite
Condo in Panamá
4.89 out of 5 average rating, 9 reviews

Modern and elegant apartment in Cinta Costera

Experience the luxurious PH Yoo overlooking the city in this elegant apartment with a king-size bed and floor-to-ceiling windows. Enjoy world-class amenities: swimming pool, gym, squash court, spa, and more. Prime location near tourist areas, restaurants, bars, and shopping malls. Inside the building there are dining options with exclusive discounts and free valet parking. Modern, spacious and sophisticated space for an unforgettable getaway.

Superhost
Apartment in Panamá
5 out of 5 average rating, 4 reviews

Cozy Studio in Cinta Costera with Home Vibes

✨ Live the "Cinta Costera Vibes" experience 🌴 from this modern studio apartment with a panoramic view of the Bay and the vibrant Balboa Avenue. Perfect for travelers looking for comfort, style, and a premium location. Enjoy the pool, restaurant, gym, and rooftop with the best sunset in Panama 🌅. Ideal for short or long stays — your home with home warmth and a 5⭐ touch. Save it as a favorite and live the Host Up experience!

Guest favourite
A modern dining area features a white table set for four, surrounded by stylish chairs. Large windows allow natural light to fill the space, revealing views of the city skyline. A sleek kitchen is visible in the background, showcasing a gas stove and granite countertops.
Apartment in Panamá
4.94 out of 5 average rating, 110 reviews

k*| Delightful 1 BR w/King Bed in Calle 50

Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Guest favourite
A well-lit bedroom features a spacious bed with light-colored bedding, complemented by decorative wall art. Natural light enters through large glass doors, which open to a small terrace with greenery. A cozy armchair is positioned nearby, enhancing the room's inviting atmosphere.
Condo in Santa Ana
5 out of 5 average rating, 23 reviews

King Bed, Creative Design Steps from Casco Viejo

Casco 114 is a stay created by travelers, for travelers. Located in the heart of Santa Ana, the creative district of Panama’s Casco viejo, it offers a king bed, full-size trundle, sofa bed, private terrace, washer/dryer, and unique decor. At PH Casco View: enjoy a saltwater pool, coworking space, stunning views of both the Old Town and the modern city, paid parking, and all the comforts for an unforgettable stay.

Guest favourite
Apartment in Panamá
4.99 out of 5 average rating, 135 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Popular amenities for Panama City vacation rentals

Frequently Asked Questions

  • What are the best places to stay in Panama City?

    Panama City has stays in vibrant neighborhoods like Casco Viejo, known for historic charm, and Punta Pacifica, often suggested for modern towers and city views. Many visitors also enjoy options around El Cangrejo for its mix of cafes and local culture.

  • What are the best things to do in Panama City with kids?

    Explore the Biomuseo’s interactive exhibits, walk the Amador Causeway for city and canal views, or visit parks like Parque Natural Metropolitano to spot wildlife. Many families enjoy boat tours or learning about the canal’s history.

  • What are some of the best things to do in Panama City?

    Wander historic streets in Casco Viejo, explore exhibits at the Panama Canal Museum, and stroll the Cinta Costera waterfront. Food and markets, canal tours, and cultural centers are frequently suggested for first-time visitors.

  • How is the weather in Panama City?

    Panama City has a tropical climate with warm temperatures year-round, often around 75–88°F (24–31°C). Visitors can expect higher humidity, with occasional rain, especially during the wet season.

  • What are the best places to visit in Panama City?

    Casco Viejo’s historic architecture, the Panama Canal, and the Biomuseo are often highlighted for visitors. The Amador Causeway is also suggested for scenic walks and views over the bay.

  • What are some hiking trails in Panama City?

    Parque Natural Metropolitano has trails through tropical forest with city vistas and wildlife. The Sendero El Gaital path and walking routes around Cerro Ancón are also frequently suggested for those who want a nature escape near urban sights.

  • What are some family activities we can do in Panama City?

    Families often enjoy the interactive displays at Biomuseo, relaxing on the Amador Causeway, and wildlife spotting in Parque Natural Metropolitano. Parks with playgrounds and canal boat tours are also popular with kids.

  • What are some of the best day trip ideas from Panama City?

    Day trips from Panama City often include hiking in nearby rainforest reserves, visiting Gamboa for canal views and nature tours, or relaxing on beaches around the Pearl Islands. Guided excursions introduce travelers to indigenous cultural sites as well.

  • Are there any pet friendly accommodations available in Panama City?

    Panama City has pet-friendly stays, especially in neighborhoods like El Cangrejo and San Francisco, where parks and walkable streets make it easy to enjoy the city with your pet. Many hosts welcome dogs and cats with advance notice.

  • What are some local tips for visiting Panama City?

    When exploring Panama City, lightweight clothing helps with humidity, and a reusable water bottle is useful. Street murals around Casco Viejo show local talent, while trying fresh seafood in city markets gives a taste of regional flavors.

  • What is Panama City known for?

    Panama City is known for the Panama Canal, mix of colonial and modern architecture, and vibrant culinary scene. Its waterfront walks and lively festivals celebrate a crossroads of cultures.

  • What are the best hidden gems to explore in Panama City?

    Panama City has tucked-away art galleries in Casco Viejo, quiet gardens at Mi Pueblito, and street food stands in Santa Ana that attract locals. Seek out small museums and indie coffee shops for a neighborhood experience.

  • What are the best foods to try in Panama City?

    Local favorites include sancocho chicken stew, patacones (fried plantains), and ceviche from city markets. Panamanian seafood, fresh tropical fruits, and pastries filled with local flavors are frequently suggested.

  • What should I bring for a trip to Panama City?

    Bring lightweight, breathable clothing for the tropical climate, comfortable walking shoes, and sun protection like hats and sunscreen. A rain jacket and an adapter for electronics are also practical for your stay.

  • What is the nightlife in Panama City like?

    Panama City has a vibrant nightlife scene, with lively rooftop bars, salsa venues, and music lounges in Casco Viejo. Neighborhoods like Calle Uruguay and El Cangrejo are known for dance clubs, craft cocktail spots, and casual pubs. Visitors often explore a mix of local rhythms and international influences after dark.

  • What are the most popular events or festivals in Panama City?

    Carnival is one of the most popular celebrations, filling Panama City with music, parades, and color before Lent. Jazz festivals, local art fairs, and folklore events also draw crowds throughout the year.

  • Are there family friendly vacation rentals in Panama City?

    Panama City has family-friendly vacation rentals, especially in areas near parks and cultural attractions like El Cangrejo, San Francisco, and Casco Viejo. Many hosts provide amenities for children and groups traveling together.

  • When is the best time to visit Panama City?

    The drier season is often recommended for clearer skies and outdoor activities. Many travelers prefer visiting when major cultural events and festivals enliven the city’s atmosphere.

Quick stats about vacation rentals in Panama City

  • Total vacation rentals

    Explore 4,860 vacation rentals in Panama City

  • Verified guest reviews

    Over 124,900 verified reviews to help you choose

  • Family-friendly vacation rentals

    1,530 properties offer extra space and kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 1,800 rentals that welcome pets

  • Vacation rentals with a pool

    2,660 properties feature pools

  • Rentals with dedicated workspaces

    2,930 properties have a dedicated workspace

  • Wifi availability

    4,620 of Panama City vacation rentals include wifi access

  • Popular amenities for guests

    Guests love Gym, BBQ grill, and Laptop-friendly workspace across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City’s top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore

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