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Vacation rentals in Panama City

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Top-rated vacation rentals in Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favourite
Apartment in Obarrio
5 out of 5 average rating, 14 reviews

Modern apartment in the heart of Obarrio

This apartment stands out for its privileged location in Obarrio, with a modern and cozy design. Located on the 14th floor, it offers a spectacular view, its decoration in neutral tones conveys serenity. The convenience of having two bathrooms makes it unique. Ideal for travelers looking for peace of mind and functionality. Located a few steps from 50th Street and the iconic El Tornillo building. You're surrounded by casinos, hotels, and restaurants. Safe area for walking and enjoying the city.

Top guest favourite
A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.
Apartment in Panama City
5 out of 5 average rating, 37 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Guest favourite
A modern living area features a large wave mural that enhances the space's vibrant decor. Comfortable seating arrangements include a sleek white sofa and a pair of stylish armchairs. A glass coffee table is centered among the furnishings, with tastefully arranged decorative accents.
Apartment in Panamá
4.93 out of 5 average rating, 262 reviews

Modern apt ocean view in heart of Panamá yoo tower

Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Top guest favourite
A bright and airy living space features large floor-to-ceiling windows offering city views. Sleek marble floors complement minimalist furnishings, including two neutral sofas and a stylish coffee table. An open kitchen area is visible in the background, enhancing the overall modern design.
Apartment in Marbella
4.98 out of 5 average rating, 40 reviews

Unique Luxury 3-story Loft at the Yoo

Experience the luxury of a world renowned Philippe Starck designed building. Our 3-bedroom sanctuary is a unique 3-story loft that boasts breathtaking city views, an open-plan kitchen, sleek marble floors, and premium amenities. Steps away from Panama City’s premier attractions, shopping, and dining. Dive into top-tier amenities: a pristine pool, state-of-the-art gym, relaxing spa, and three of the best restaurants in the city! Embrace Panama in unmatched style.

Guest favourite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Apartment in Panamá
4.98 out of 5 average rating, 146 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Guest favourite
A modern living area is showcased, featuring a light gray sofa positioned across from a flat-screen TV on a wooden console. Two abstract art pieces adorn the walls. Floor-to-ceiling windows offer views of the city skyline, enhancing natural light in the space.
Condo in Panamá
4.94 out of 5 average rating, 127 reviews

Beautiful Apartment 3 guests

Moderno, elegante y cómodo departamento, cerca de todo! Restaurantes, farmacias, supermercados, canchas de padle, a pocos minutos del centro comercial Multiplaza. Totalmente amoblado, 1 recamara, 1 baño completo, walking closet, cocina, sala, área de desayunador, lavadora-secadora y balcón. Para su disfrute, piscina de agua salada en el último piso, gimnasio, espacio de co-working, incluye un espacio de estacionamiento con valet parking.

Guest favourite
The entrance to the building is framed by manicured trees and architectural elements. Large glass doors lead into the space, reflecting warm lighting from chandeliers overhead. A pathway lined with tiles guides the way, creating a welcoming approach.
Apartment in Panamá
5 out of 5 average rating, 21 reviews

Modern and luxurious apartment in Cinta Costera

Experience the luxurious PH Yoo experience with city views in this elegant apartment with king bed and floor-to-ceiling windows. Enjoy upscale amenities: swimming pool, gym, squash court, spa, and more. Privileged location close to tourist areas, restaurants, bars and malls. Inside the building there are gastronomic options with exclusive discounts and free valet parking. Modern, spacious and sophisticated space for an unforgettable getaway.

Guest favourite
An aerial view showcases a vibrant pool area featuring a flower-patterned design, surrounded by lounge chairs and numerous umbrellas. A hot tub is positioned beside the pool, with the modern building rising in the background, adding a sleek architectural element.
Apartment in Panama City
5 out of 5 average rating, 10 reviews

Luxury apartment in the Panamá city

This apartment perfectly combines comfort, style, and location. You'll love its modern design, impeccable cleanliness, and peaceful atmosphere. It's equipped with everything you need to feel at home and offers a beautiful view. Plus, you'll be in a prime location, close to restaurants, shopping centers, and with easy access to transportation. Ideal for business trips or simply enjoying the city from a comfortable and stylish location.

Top guest favourite
An inviting living area is featured, showcasing a modern grey sofa accented with decorative pillows. A round glass dining table is surrounded by chairs, and artistic wall frames complement the space. Natural light is filtered through elegantly layered window shades.
Apartment in Panamá
4.97 out of 5 average rating, 116 reviews

Luxury apartment in downtown Panama, banking area

We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Guest favourite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.93 out of 5 average rating, 129 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favourite
Apartment in Panamá
4.99 out of 5 average rating, 118 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Top guest favourite
Condo in Panama
4.99 out of 5 average rating, 256 reviews

Patty’s Cozy Studio with K bed in Casco Viejo

Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen aside from the main living space. It is spacious, comfortable and tastefully decorated!

Popular amenities for Panama City vacation rentals

Quick stats about vacation rentals in Panama City

  • Total rentals

    4.7K properties

  • Nightly prices starting at

    $14 CAD before taxes and fees

  • Total number of reviews

    114K reviews

  • Family-friendly rentals

    1.5K properties are a good fit for families

  • Pet-friendly rentals

    1.7K properties allow pets

  • Rentals with a pool

    2.6K properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City