Vacation rentals in Wapello

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Top-rated vacation rentals in Wapello

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favourite
A historic four-bedroom home is captured with tall trees framing the exterior, set against a clear blue sky. The architectural features include a prominent turret and multiple windows, reflecting the home's charm. A snow-dusted yard leads to a view of the nearby Mississippi River.
Home in Muscatine
4.96 out of 5 average rating, 151 reviews

Historic West Hill Retreat

Beautiful historic 4 bedroom, 4 bath home within walking distance to shopping, bars/restaurants and all that downtown Muscatine has to offer. Enjoy sweeping views of the Mississippi River from several vantage points in and outside this home. The 3000 sf interior offers many places to gather and relax. Two of the bedrooms have on suite full baths. The other two bedrooms share a full bath. Additional amenities include, fully equipped kitchen, laundry, games, grill, outdoor entertainment area.

Top guest favourite
Two horseback riders are positioned on a grassy hill overlooking a tranquil pond. The clear water reflects the surrounding greenery, enhancing the serene rural setting. The landscape features rolling hills, contributing to a peaceful country experience.
Farm stay in Riverside
4.92 out of 5 average rating, 373 reviews

Farm stay close to Iowa City, IA

15 min.-Iowa City, 5 min- Riverside Casino, & 35 min-Eastern Iowa Airport, Cedar Rapids, IA. Comfy beds, living room sectional pulls out to queen hide a bed, 32 acres, horseback riding (sm. fee)*, winter fun, & fishing pond. First 2 guests pay base price, then 3rd thru 10th guests pay an extra 30.00 EACH. NO PARTIES on our farm. We live on property in a separate home. Dogs welcomed (must be kenneled when you leave property). We have an oven and cookware in kitchenette. *contact for details.

Top guest favourite
A screened porch features a round table surrounded by four chairs, all with green cushions. Natural light streams through the screens, showcasing views of a tranquil lake framed by colorful autumn foliage.
Guesthouse in Berwick
4.98 out of 5 average rating, 254 reviews

Private Guest Lake House On 37 Acres In Country

Private guest lake house, located next to main house, on private lake in the country. 2 bedroom, 1 full bath, full kitchen, washer and dryer and large attached screen porch. Private 37 acres of woods and prairie. Fishing and walking trails. Great window views of lake, woods, prairies and river valley. Please note, this guest house is located 1 mile down a county maintained gravel road. 25 minutes from Galesburg, IL, 20 minutes from Monmouth, IL and 35 minutes from Macomb, IL.

Top guest favourite
A spacious living area features large windows that allow for natural light, showcasing scenic views of the outdoors. Modern furniture, including a sectional sofa and accent chairs, is arranged around a central coffee table. A spiral staircase is visible, leading to an upper level.
Cabin in Princeton
4.96 out of 5 average rating, 157 reviews

Private & Modern. Near river and wildlife refuge!

Experience the outdoors in comfort from this modern cabin, situated next to the 2200 acre Princeton Wildlife Management Area, and the nearby Mississippi River. It is ranked as the most “Wish Listed” Iowa listing of 2025 on Airbnb. Are you into hiking, biking, fishing, hunting, boating, or other water, winter, and summer sports? This cabin can support it all! Sit back and relax on the large deck while enjoying a coffee & the local wildlife, flora, & fauna of the Mississippi Valley Region.

Guest favourite
A spacious home is visible with a combination of brick and siding exterior, featuring multiple gables and a large covered porch. A manicured lawn extends toward a serene pond, enhancing the natural surroundings. Clear blue skies contribute to the relaxing outdoor atmosphere.
Home in Morning Sun
4.91 out of 5 average rating, 256 reviews

Buckman's Bed and Breakfast (5 Bedrooms+)

Enjoy the comfort and welcoming atmosphere of a home built to entertain family & friends. There are 5 guest bedrooms rooms: Room 1-King bed, sofa bed & recliner Room 2-Queen & sofa bed Room 3-Twin beds & convertible sofa Room 4-Queen & sofa bed Room 5-King & recliner Rooms 1,2 &5 have in suite bathrooms. Bathroom for room 4 is next door. Rooms 2 &3 share an inner door; ideal for parents with children. Breakfast is included. To book a room instead of the house, see separate listings.

Guest favourite
A charming two-story house features a welcoming front porch with steps leading up to the entrance. The property is surrounded by a well-maintained lawn, with trees providing shade and a white picket fence outlining the yard. A driveway is visible to the side.
Home in Burlington
4.89 out of 5 average rating, 155 reviews

Cheerful Bungalow with original woodwork

This home features original woodwork, charm and character- great open front porch and back porch, living room, dining room and eat in kitchen, 3 upper level bedrooms. Full basement with laundry plus shower and stool. There is a desk for when you need a quick catch on your laptop or ipad. Relax on the porch or in the original metal kitchen with glass panels and enamel farmer sink. 1 large bedroom with queen bed and two small bedrooms with double bed Basic cable and WIFI included

Top guest favourite
A vibrant garden of zinnias in shades of pink and orange flourishes in the foreground, leading to a red barn in the background. The barn features a gabled roof and is surrounded by greenery, creating a serene outdoor scene.
Barn in Solon
4.97 out of 5 average rating, 145 reviews

Beautiful, cozy barn in the quiet countryside

Come enjoy a relaxing get away on beautiful Sugar Bottom Road. A great place for the outdoor enthusiast, no matter the season. Ideal also for quiet relaxation and privacy. We are a small acreage just 15 minutes from Iowa City, 7 minutes from Solon, and 30 minutes from the Cedar Rapids airport. Our converted barn is at the back of the property, behind the house. There is a separate road leading back to the barn for super convenient parking. It’s rustic, cozy, warm and inviting.

Top guest favourite
The exterior of the Milk House features a red structure with gray siding, adorned with a triangular window and a decorative sun motif. A small porch with a welcome sign opens to a gravel path lined with flower planters. A chair and table are set for outdoor relaxation.
Farm stay in Iowa City
4.98 out of 5 average rating, 412 reviews

The Milk House at Lucky Star Farm

The Milk House is a unique space located in the countryside, between Iowa City and Kalona. This 700 square foot home has ample parking and room for four adults. The house is well appointed with a full kitchen, two luxurious queen beds, wifi and a Smart TV. Guests are invited to explore our 20-acre working farm with lots of livestock and two friendly dogs. It's a perfect blend of rural living with the perks of beautiful Iowa City 15 minutes away. Come unwind at Lucky Star Farm!

Guest favourite
A vibrant mural featuring a peacock is displayed on a white wall, contrasting with the rustic brick backdrop. The neon sign reading 'The Peacock Loft' adds a modern touch, while a dark staircase leads upward, highlighted by industrial-style lighting.
Loft in Burlington
4.98 out of 5 average rating, 301 reviews

The Peacock Loft / Spacious Artistic Loft

A whimsical, art-filled retreat. Filled with treasured pieces from years of travel and free-spirited living, the loft is now a space for rest, inspiration, and slow mornings. Layered with color, photography, books, and meaningful objects, it’s perfect for guests who love creative, collected spaces. Please note: this is an older urban building with character, multiple stairs, no elevator, and some city noise. Fans, sound machines, blackout curtains, and earplugs are provided.

Guest favourite
A living room features a leather sofa, two vintage armchairs, and a round ottoman, creating a cozy seating arrangement. Natural light enters through large windows framed with sheer curtains. Dark wooden flooring contrasts with the light-colored walls and decorative art pieces are displayed throughout.
Home in Burlington
4.9 out of 5 average rating, 236 reviews

The Fleetwood Bungalow with Dreamy Porch

Welcome to The Fleetwood Inn! A charming, cozy one-bedroom bungalow in the heart of Burlington, Iowa. Right between our bustling business district and our nostalgic downtown, this little house has vast character. My favorite feature is all the original built-ins and beams. You will love the Western American inspiration and vintage finds, modern touches throughout, and dreamy details in every corner. Just added a Saatva Organic mattress for extra comfort.

Guest favourite
A bright and spacious bedroom features a comfortable bed with a layered blanket, complemented by decorative pillows. A fan hangs from the ceiling, and artwork adorns the wall above the bed. A small desk and chair are visible in the corner, providing a work area.
Guesthouse in Mount Pleasant
4.92 out of 5 average rating, 131 reviews

The Vernon Street Guest House - Suite 2

Built in 1900 and renovated in 2022, Suite 2 shows little signs of the once quirky old space. Completely private, with all the amenities, it boasts a spacious bedroom, 1 bathroom, a fully equipped kitchen, dining area, living room with a desk for workspace, and a laundry room. While you're here, we hope you are able to relax and enjoy the well lit deck along with a cup of freshly roasted coffee, which we are happy to have provided.

Top guest favourite
A black mailbox stands on a white post displaying the address '306 N. 2nd St.' The mailbox is wet from recent rain, with a grassy area surrounding it and a road visible in the background. Trees line the street, contributing to a quiet, residential setting.
Home in Oquawka
4.98 out of 5 average rating, 125 reviews

The Little House

The Little House started as a cabin in the early 1900’s. A refreshed cozy getaway in a great little river town. Restaurants, bars and river access are walkable or close drive. Plenty of room to park boat etc.

Popular amenities for Wapello vacation rentals

  1. Airbnb
  2. United States
  3. Iowa
  4. Louisa County
  5. Wapello