Guesthouse vacation rentals in Anderson County
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Top-rated guesthouses in Anderson County
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Anderson County guesthouses
Family-friendly guesthouses
Guesthouse in Pelzer
4.97 out of 5 average rating, 111 reviewsSouth Oaks Guesthouse
Guesthouse in Pendleton
4.9 out of 5 average rating, 240 reviewsLa Bella Farm
Guesthouse in Townville
4.88 out of 5 average rating, 231 reviewsLisa’s Lodge
Guesthouse in Anderson
4.94 out of 5 average rating, 234 reviewsBe Our Guest
Guesthouse in Donalds
4.99 out of 5 average rating, 346 reviewsHome on the farm
Guesthouses with a patio
Guesthouse in Greenville
4.99 out of 5 average rating, 70 reviewsFinished Room over Garage (FROG) on Reedy River
Guesthouse in Seneca
5.0 out of 5 average rating, 20 reviewsOne Particular Cove ... on Lake Hartwell
Guesthouse in Piedmont
4.98 out of 5 average rating, 46 reviewsShou-Sugi-Ban Retreat on the Saluda River
Guesthouse in Central
5.0 out of 5 average rating, 9 reviewsVacation Home Clemson and Lakes
Guesthouse in Pendleton
5.0 out of 5 average rating, 8 reviewsNested Studio Woodscape
Guesthouse in Seneca
5.0 out of 5 average rating, 6 reviewsQuin's Lake House, Keowee. Private bottom Floor.
Guesthouse in Greenville
5.0 out of 5 average rating, 64 reviewsSally's Cottage
Guesthouse in Clemson
5.0 out of 5 average rating, 32 reviewsDowntown Clemson Guest Suite!
Guesthouse rentals with a washer and dryer
Guesthouse in Six Mile
4.89 out of 5 average rating, 97 reviewsCamper at Hickory Lodge and Guesthouse
Guesthouse in Greenville
4.82 out of 5 average rating, 44 reviewsTheArk
Guesthouse in Anderson
4.86 out of 5 average rating, 7 reviewsCozy 2BR lakeside apt w dock near marina & Clemson
Guesthouse in Anderson
4.94 out of 5 average rating, 169 reviewsPrivate - Lake getaway with 7 mile view from dock
Guesthouse in Anderson
4.86 out of 5 average rating, 169 reviewsFarmhouse by the lake - Private guest house
Guesthouse in Clemson
5.0 out of 5 average rating, 6 reviewsClemson Carriage House - NEW!
Guesthouse in Townville
5.0 out of 5 average rating, 7 reviewsParadise Point on Lake Hartwell
Guesthouse in Clemson
5.0 out of 5 average rating, 9 reviewsRiggs Drive Gameday Getaway
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