Guesthouse vacation rentals in South Carolina

The Guesthouse at Old Orchard

Relax in the treetops of our beautiful pecan grove! Guests adore the peaceful surroundings of our new 1260 sq ft guesthouse located on the second floor of a detached garage. This private space has an open floor plan, fully stocked kitchen, 2 queen bedrooms, 2 full baths, wifi, Roku TVs, and new appliances including washer and dryer. Sitting on 1.3 acres, the property is home to gardens, a tidal creek, and happy hens! It is quiet yet centrally located between downtown Charleston and Folly Beach.

The Little Red Guesthouse

Before booking, please note this property is on a bridge-less island, not accessible by your vehicle. You will need to set up water transportation as well as a golf cart rental on island for your stay. The rental is nestled in the historic district of Daufuskie, an underdeveloped, quirky island. The guesthouse shares a deck with the main house. Enjoy a separate entrance, shower, kitchenette and bedroom. Minutes from the beach, island artisans and restaurants, this rental is a perfect getaway. .

The Travelers Loft

Light and airy contemporary guest house with new upscale furnishings, nestled on 40 acres of woodland and meadows. Perfect for 2-4 guests. 2.5 miles from downtown Travelers Rest and the 'Swamp Rabbit Trail'. Great for biking or walking. 25 minutes to the city of Greenville and 45 to the mountains of Asheville, NC. Located less than 30 minutes from the Greenville Airport. This second story guest house has private parking, and a beautiful deck for grilling out or just relaxing after a busy day.

Liz Lane Cottage- entire guesthouse

Our brand new guest house is a spacious one bedroom, one bath with a bunk loft. Come enjoy our quiet neighborhood after a full day of sightseeing. Located 2 miles from downtown, 10 miles from Folly beach or Sullivan’s island, this tastefully decorated guest house will not disappoint! Guests will have access to the entire cottage. The backyard is shared with the main house.This quaint West Ashley neighborhood is seated in between downtown and the trendy shops of Avondale. STR permit #04191

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

LOCATION, LOCATION, LOCATION! Welcome to Persimmon Place, a brand new guesthouse in the heart of Old Village in Mt. Pleasant. Historic Old Village is one of Charleston's most beautiful neighborhoods, central to all Charleston has to offer. This 2BR 1 BA is the perfect spot for your Lowcountry visit. -Walk to Shem Creek with bars, restaurants, & water activities -Less than 4 miles(8 min drive)to Sullivan's Island Beach -5 miles(9 min drive)to downtown Charleston ST240164 BL20127902

The Guest House By The River

Our Guest House is a quaint little place perfect for couples getaway. It is located on Chauga River, with a great swimming hole and beach. Perfect location if you are interested in River rafting (Chattooga River rafting is near by). If you enjoy hiking, fishing or just enjoying outdoors this is the place for you. Guest House is located to the right of the main house, but it is private. We would love to have you!! Close to Clemson, Cashiers, Highlands, Chattooga Belle Farms.

The Violet Villa w/no cleaning fee

Come enjoy this beautiful private guesthouse conveniently located minutes from shopping, food, venues and the beach. When you arrive, we have cooled bottled water to quench your thirst. As the evening sets, stroll the nature trail and catch the sunset from the neighborhood dock. A 70” smart tv awaits your return so you can watch your favorite movies (without sharing an armrest). Come relax! This is a vacation for you

Cozy Getaway Nestled in Nature

Welcome to your ideal retreat, perfectly situated only 20 minutes from Folly Beach, 15 minutes from Kiawah, and a 15-minute drive to the vibrant heart of downtown Charleston. Recent guests have great things to say! "Extremely clean and cozy cottage...10/10 would recommend! " "This place is a true hidden gem, it looks exactly like it’s pictures." "This AirBnB was probably the best I've experienced so far. "

Spacious 1 bedroom cottage in Avondale

Relax and unwind at this stylish and peaceful cottage. Whether relaxing in your living room or enjoying morning coffee in your private courtyard, this cottage has everything you'll need for an enjoyable stay. Located in the Avondale neighborhood of West Ashley we are walking distance from restaurants, wine bars, breweries and more. Downtown is a quick 5 minute car ride away with even more to explore.