
Guesthouse vacation rentals in South Carolina
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Top-rated guesthouses in South Carolina
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for South Carolina guesthouses
Family-friendly guesthouses

Red Roof Loft @ FireFly Farm

Bungalow on a 3 acre mini farm

Camper at Hickory Lodge and Guesthouse

Foothills Favorite

Cozy studio apartment, convenient location

Home on the farm

Alli B's Air B and B-Great Country access off 278

Lizzi & Scott’sTiny Guest House secluded USC-Vista
Guesthouses with a patio

Quaint Cottage Studio in Ashley Forest (Avondale).

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

Driftwood Cottage

My Happy Place

The Violet Villa w/no cleaning fee

Cozy Cottage! 5 mins from Kiawah!

Restful Refuge

5 Star Private Guest House • Heart of Park Circle
Guesthouse rentals with a washer and dryer

Camden Coach House Long term stay southern balance

The Guest House By The River

James Island "La Casita" Nestled btw Beach & City

Summerville’s Tiny Oak Hideaway

Cozy Park Circle, Charleston Guest House

Private-Lake getaway-7 mile view from dock

Brand New Studio Guest House with Full Kitchen.

The Cottage @JustA'MereLodge
Destinations to explore
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