Guesthouse vacation rentals in South Carolina

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Top-rated guesthouses in South Carolina

Guests agree: these guesthouses are highly rated for location, cleanliness, and more.

Guest favourite
Guesthouse in Bluffton
Bluffton's Tropical Carriage House Getaway
Embrace the inviting atmosphere of this detached garage apartment. The guesthouse features an open-concept living/kitchen/sleeping area, a tropical design, a private entry, a luxury king mattress and blackout window treatments. Spacious carriage house apartment with king size Stearns&Foster mattress. This space offers a living area with sofa, chair, table with barstools and tv with Netflix as well as other apps that you access. *We do not have cable or local channels. The kitchenette has lots of utensils, plates, glasses, toaster, coffee pot, plug-in induction burner with pots and pans, and a panini press. There is also a ceiling fan for temperature control, or if you are like us and want to sleep with the fan on. In addition there is walk-in closet with hangers and luggage rack for you to hang your clothes and keep your luggage. Fresh towels and toiletries are available for your stay. Other amenities include a hair dryer, curling iron, iron and ironing board, beach towels and beach blanket. You have access to the carriage house apartment and all of its amenities. You are welcome to use our backyard as well, and our wonderful bed swing (thanks to Joey's craftmanship) that's on our front porch. We're also willing to run a load of laundry for you if the need should arise. Brittani works from home, so she will normally be able to assist you if you should need anything. We are both available by our cell phone. We are relatively new to the Bluffton/Hilton Head area, but would love to share our finds with you. This southern style hood offers ample sidewalks, ponds for fishing, a playground, and a park. Quaint Old Town Bluffton is a 3 minute drive or 20 minute walk to a number of shops and restaurants. Unfortunately public transportation is not readily available, so if you are not wishing to use your car then you can easily walk to a good bit of amenities or call for an Uber. Our puppy son, Gunner, is a lovable Labradoodle. He is very friendly and will most likely be barking at the door of our home when you arrive, but we promise it's all for show! You might encounter him in the backyard during your visit :)
4.97 out of 5 average rating, 672 reviews
Guest favourite
Guesthouse in Abbeville
Quiet, Romantic Loft in the Woods
Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!
May 16 – 23
$104 CAD per night
4.97 out of 5 average rating, 282 reviews
Guest favourite
Guesthouse in Beaufort
Sunset River House
Our quaint little River House rests on the beautifully natural marsh grass banks of the Whale Branch River in a quiet rural neighborhood. It is located only 9 miles from Historic Downtown Beaufort and 15 miles from Parris Island Marine Corps Recruit Depot. Hunting Island State Park's sandy beaches, nature tails, and lighthouse tours are a scenic 40 minute drive away. You can swim, fish, kayak or go boating right from the dock in our own back yard. When you arrive; you won't want to leave!
Jan. 15 – 22
$164 CAD per night
4.96 out of 5 average rating, 201 reviews

Popular amenities for South Carolina guesthouses

Family-friendly guesthouses

Guest favourite
Guesthouse in Salem
Mountain Edge Loft
Jul. 30 – Aug. 6
$119 CAD per night
4.88 out of 5 average rating, 285 reviews
Guest favourite
Guesthouse in Greenville
Historic 19th Century Cabin/Guest House
Jan. 6 – 13
$130 CAD per night
4.92 out of 5 average rating, 563 reviews
Guest favourite
Guesthouse in West Columbia
Carriage House: Studio Bed & Bath - Pool & Hot Tub
Oct. 23 – 30
$142 CAD per night
4.94 out of 5 average rating, 585 reviews
Guest favourite
Guesthouse in Ridgeville
Pond House Bungalow at Natural Gathering Grounds
Jun. 9 – 16
$143 CAD per night
4.82 out of 5 average rating, 207 reviews
Guest favourite
Guesthouse in Summerville
★Delightful guest house near historic plantations★
Feb. 17 – 24
$258 CAD per night
4.98 out of 5 average rating, 628 reviews
Guest favourite
Guesthouse in Townville
Lisa’s Lodge
Aug. 2 – 9
$137 CAD per night
4.87 out of 5 average rating, 223 reviews
Guest favourite
Guesthouse in Camden
Red Roof Loft @ FireFly Farm
Apr. 18 – 25
$145 CAD per night
4.94 out of 5 average rating, 174 reviews
Guest favourite
Guesthouse in Lexington
Come Pause and Relax!
Apr. 2 – 9
$222 CAD per night
4.94 out of 5 average rating, 242 reviews
Guest favourite
Guesthouse in Bluffton
Hickory Trace Carriage House
Nov. 10 – 17
$204 CAD per night
4.98 out of 5 average rating, 346 reviews
Guest favourite
Guesthouse in Greer
Executive Suite on a farm @GSP Airport
Jun. 3 – 10
$133 CAD per night
4.96 out of 5 average rating, 232 reviews
Guest favourite
Guesthouse in Donalds
Home on the farm
Oct. 4 – 11
$196 CAD per night
4.99 out of 5 average rating, 336 reviews
Guest favourite
Guesthouse in Charleston
Spacious Daniel Island Apartment
Jun. 18 – 25
$241 CAD per night
4.99 out of 5 average rating, 259 reviews

Guesthouses with a patio

Guest favourite
Guesthouse in Fort Mill
Carriage House Suite on Lake Wylie
Jul. 18 – 25
$242 CAD per night
4.96 out of 5 average rating, 123 reviews
Guest favourite
Guesthouse in Charleston
Studio Apartment Minutes to Downtown Charleston
Feb. 11 – 18
$254 CAD per night
4.97 out of 5 average rating, 115 reviews
Guest favourite
Guesthouse in Charleston
Quaint Cottage Studio in Ashley Forest (Avondale)
Feb. 11 – 18
$209 CAD per night
4.93 out of 5 average rating, 157 reviews
Guest favourite
Guesthouse in North Charleston
The Park Circle Clerestory Studio Guest House
May 20 – 27
$255 CAD per night
5.0 out of 5 average rating, 102 reviews
Guest favourite
Guesthouse in Charleston
Private Backyard With Fire Pit, 15 Min to Downtown
Sep. 21 – 28
$326 CAD per night
4.98 out of 5 average rating, 110 reviews
Guest favourite
Guesthouse in Columbia
Renovated One Bedroom Guest House by UofSC
Jul. 19 – 26
$137 CAD per night
4.96 out of 5 average rating, 142 reviews
Guest favourite
Guesthouse in Camden
Mingo's Hideaway-Downtown Camden
Dec. 17 – 24
$139 CAD per night
5.0 out of 5 average rating, 55 reviews
Guest favourite
Guesthouse in Inman
Foothills Favorite
Sep. 29 – Oct. 6
$130 CAD per night
5.0 out of 5 average rating, 85 reviews
Guest favourite
Guesthouse in Abbeville
1-bedroom guesthouse in Abbeville, SC
Dec. 12 – 19
$123 CAD per night
4.95 out of 5 average rating, 98 reviews
Guest favourite
Guesthouse in Pawleys Island
The BELLA at Hagley Landing Boating Beach Golf
Nov. 10 – 17
$170 CAD per night
4.96 out of 5 average rating, 70 reviews
Guest favourite
Guesthouse in Campobello
Bungalow on a 3 acre mini farm
Aug. 9 – 16
$127 CAD per night
4.97 out of 5 average rating, 60 reviews
Guest favourite
Guesthouse in Fountain Inn
The Woodlands - Spacious Apt in Central Location!
Nov. 1 – 8
$117 CAD per night
4.85 out of 5 average rating, 79 reviews

Guesthouse rentals with a washer and dryer

Guest favourite
Guesthouse in Beaufort
Buddy's Cottage near everything in Beaufort, SC
Jan. 28 – Feb. 4
$180 CAD per night
4.98 out of 5 average rating, 178 reviews
Guest favourite
Guesthouse in Florence
Midtown Retreat - Guest House in heart of Florence
Jul. 26 – Aug. 2
$147 CAD per night
4.93 out of 5 average rating, 107 reviews
Guest favourite
Guesthouse in Abbeville
Modern Carriage House
May 18 – 25
$157 CAD per night
4.99 out of 5 average rating, 143 reviews
Guest favourite
Guesthouse in Saint Helena Island
Charming Waterfront Cottage with Beautiful Views.
Aug. 3 – 10
$275 CAD per night
4.99 out of 5 average rating, 182 reviews
Guest favourite
Guesthouse in Lyman
Blue Heron Hideaway Lakeside Retreat
Aug. 16 – 23
$210 CAD per night
4.99 out of 5 average rating, 117 reviews
Guest favourite
Guesthouse in Lexington
Lake front Lake Murray in the Heart of Lexington
May 21 – 28
$377 CAD per night
4.99 out of 5 average rating, 141 reviews
Guest favourite
Guesthouse in Camden
Camden Coach House Long term stay southern balance
Jul. 13 – 20
$170 CAD per night
4.9 out of 5 average rating, 257 reviews
Guest favourite
Guesthouse in Mount Pleasant
Guesthouse Convenient to Charleston, Shem Creek, and Beaches
Sep. 17 – 24
$268 CAD per night
4.97 out of 5 average rating, 397 reviews
Guest favourite
Guesthouse in Charleston
Detached Guest Suite
Nov. 3 – 10
$212 CAD per night
4.98 out of 5 average rating, 243 reviews
Guest favourite
Guesthouse in Mount Pleasant
Old Mt. Pleasant/Shem Creek close to Sullivans/DT
Oct. 18 – 25
$321 CAD per night
4.98 out of 5 average rating, 420 reviews
Guest favourite
Guesthouse in Charleston
Large Guesthouse with Private Dock & Marsh Views
Oct. 24 – 31
$386 CAD per night
4.98 out of 5 average rating, 132 reviews
Guest favourite
Guesthouse in Mount Pleasant
Cozy Apartment in Mount Pleasant
Dec. 29 – Jan. 5
$209 CAD per night
4.97 out of 5 average rating, 216 reviews

Destinations to explore