Guesthouse vacation rentals in South Carolina
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Top-rated guesthouses in South Carolina
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for South Carolina guesthouses
Family-friendly guesthouses
Guesthouse in Townville
4.88 out of 5 average rating, 238 reviewsLisa’s Lodge
Guesthouse in Greenville
4.92 out of 5 average rating, 606 reviewsHistoric 19th Century Cabin/Guest House
Guesthouse in West Columbia
4.95 out of 5 average rating, 620 reviewsCarriage House: Studio Bed & Bath - Pool & Hot Tub
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 235 reviewsStudio Apt - (Pets/beach/pool/golf)
Guesthouse in Salem
4.89 out of 5 average rating, 296 reviewsMountain Edge Loft
Guesthouse in Ridgeville
4.82 out of 5 average rating, 219 reviewsPond House Bungalow at Natural Gathering Grounds
Guesthouse in Charleston
4.92 out of 5 average rating, 317 reviewsMother in Law in James Island Riverland Terrace
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 226 reviewsBungalow Under The Oaks
Guesthouses with a patio
Guesthouse in Hilton Head Island
4.89 out of 5 average rating, 107 reviewsAlli B's air B and B-great country access off 278
Guesthouse in North Charleston
5 out of 5 average rating, 124 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in Fort Mill
4.94 out of 5 average rating, 151 reviewsCarriage House Suite on Lake Wylie
Guesthouse in Greenville
4.93 out of 5 average rating, 107 reviewsCozy Downtown GVL Studio
Guesthouse in Columbia
4.94 out of 5 average rating, 103 reviewsQuaint Haven: Your Cozy Retreat
Guesthouse in Charleston
4.95 out of 5 average rating, 104 reviewsBoHo styled casita in adorable neighborhood...
Guesthouse in Columbia
4.95 out of 5 average rating, 153 reviewsRenovated One Bedroom Guest House by UofSC
Guesthouse in North Charleston
4.9 out of 5 average rating, 101 reviewsMy Happy Place
Guesthouse rentals with a washer and dryer
Guesthouse in Charleston
4.98 out of 5 average rating, 231 reviewsGuest suite w/ patio, 12min to city, pet-friendly
Guesthouse in Camden
4.91 out of 5 average rating, 282 reviewsCamden Coach House Long term stay southern balance
Guesthouse in Abbeville
4.99 out of 5 average rating, 150 reviewsModern Carriage House
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 129 reviewsBeach, downtown, Alhambra Hall weddings so close!
Guesthouse in Six Mile
4.89 out of 5 average rating, 102 reviewsCamper at Hickory Lodge and Guesthouse
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 269 reviews#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Guesthouse in Charleston
4.99 out of 5 average rating, 270 reviewsSpacious Daniel Island Apartment
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 452 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
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