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Vacation rentals in Florence

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Top-rated vacation rentals in Florence

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favourite
Home in Florence
Kuker Cottage Downtown Florence-Near I95 & I20
Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20
Apr. 12 – 19
$219 CAD per night
Guest favourite
Guest suite in Florence
Private Apartment 5 Min Away From I-95 & I-20
Please come and enjoy our Guest Apartment in Florence, SC! A great stop for travelers to rest during their trips. Guests will have a private entrance to the apartment that is attached but separate from the main house, where me and my family live. Guest privacy will always be respected. One bedroom has a queen size bed, a second bedroom has a daybed. The bathroom has a tub and shower. The kitchen has a stove/oven. The apartment is cleaned and sanitized after each guest leaves. Thank you!
Mar. 22 – 29
$131 CAD per night
Guest favourite
Cottage in Timmonsville
*Cottage Near Florence and I-95*
Located just 5 mins from I-95 (exit 153) and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, please). We offer king bed in master, 3 wall-mounted TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. Lock Box on front door for self-check-in! Come stay with us. 🙂
Apr. 21 – 28
$192 CAD per night

Popular amenities for Florence vacation rentals

Stay near Florence's top sights

Florence Center3 locals recommend
Percy & Willies3 locals recommend
Red Bone Alley Restaurant15 locals recommend
The Drive In3 locals recommend
Timrod Park7 locals recommend
Tubb's Shrimp and Fish Co.9 locals recommend

Other great vacation rentals in Florence

Guest favourite
Treehouse in Marion
Enchanting Treehouse with Modern Amenities
Nov. 27 – Dec. 4
$414 CAD per night
Guest favourite
Cottage in Sumter
Restful Lakeside Getaway Cottage -Dogs allowed.
Feb. 21 – 28
$179 CAD per night
Guest favourite
Home in Lake City
Home Away From Home Apt 3 - A Hidden Gem
May 16 – 23
$95 CAD per night
Guest favourite
Home in Florence
Renovated 2 BR/2 B Townhouse Cozy & Clean
May 23 – 30
$186 CAD per night
Guest favourite
Condo in Florence
☑️Cozy Work Friendly Condo in Florence☑️
Mar. 12 – 19
$145 CAD per night
Guest favourite
Cottage in Florence
DOWNTOWN Pine Cottage
Sep. 15 – 22
$117 CAD per night
Guest favourite
Bungalow in Florence
Quaint Bungalow in Historic Downtown Florence
Jun. 14 – 21
$242 CAD per night
Guest favourite
Home in Florence
Pineapple House Historic Southern Charm Downtown
Apr. 7 – 14
$171 CAD per night
Guest favourite
Condo in Florence
Modern 1 bedroom condo near downtown Florence
Sep. 15 – 22
$109 CAD per night
Guest favourite
Home in Florence
Travelers welcome near Starbucks and Krispy Kreme
Mar. 21 – 28
$134 CAD per night
Guest favourite
Apartment in Florence
Modern 3B/2Ba Condo- Sleeps 6, near Civic Center
Dec. 2 – 9
$270 CAD per night
Home in Florence
Can do condo!
Mar. 23 – 30
$143 CAD per night

Quick stats about vacation rentals in Florence

Total rentals

120 properties

Rentals with dedicated workspaces

70 properties have a dedicated workspace

Pet-friendly rentals

30 properties allow pets

Family-friendly rentals

60 properties are a good fit for families

Total number of reviews

3.4K reviews

Nightly prices starting at

$14 CAD before taxes and fees

Destinations to explore