
Guesthouse vacation rentals in La Mesa
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Top-rated guesthouses in La Mesa
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for La Mesa guesthouses
Family-friendly guesthouses

Adorable San Diego Guesthouse
I have never stayed in South Park before. This location was so fun! Lots of little places to walk to. No issues with parking.

Fig Tree Bungalow
This place was great for our quick weekend trip. Definitely worth the price.

Pacific Beach Guest House With Garage and A/C
Had a great stay at this Airbnb. hist provided excellent instructions and the space was accurately described in the listing. Was a great basecamp for visiting San Diego friends and exploring the city.

The BEST NEST Clean, peaceful, private, affordable
Love Teri’s place! Feels just like home whenever we stay there. Walking distance to Better Buzz Coffee and Vons for groceries. Everything you need is there for you to make the place feel like home away from home. Teri was a great host too, can’t recommend her enough for anyone wanting to stay in San Diego.

Retreat house. Nature, Hot Tub, Views!
We had a wonderful stay at Meaghan's place! She was non intrusive yet quick to respond when we had a question. As for the airbnb, it was spectacular! Inside was comfortable and had everything we needed. The outside - well the pictures can't quite capture the intense beauty of the surroundings. I loved the yoga platform and playing with her cats. A great place to decompress and make peace with the world.

Vineyard & Winery Guest House
Beautiful location with hiking and delicious wine. Clean and cozy accommodation with everything needed to cook a few meals. Gorgeous garden and cute cats. Sarah was friendly and helpful.

Cosy quiet Guesthouse near SDSU
I think this place was well worth what it was advertised. Great location host was very responsive and I will book again if I’m in the area..

Charming North Park Cottage
We thoroughly enjoyed our short stay at Patricia’s place. The location is within walking distance of numerous restaurants and bars and is a short drive to downtown San Diego, Little Italy etc. The home was clean and comfortable and perfect for two people. I met Patricia briefly as we were leaving. She was very friendly and had we been staying longer I would’ve asked her for local recommendations. I will absolutely stay there again when I’m back in California. Thank you, Patricia!
Guesthouses with a patio

Adorable cottage in Talmadge
Another great visit! Convenient location coupled with wonderful amenities, along with Carlos’ hospitality makes this a top choice for us when visiting San Diego to see our son!

Private 1 BR Paradise retreat
Great stay & wonderful hosts. We'll be back for sure!

La Jolla Oasis: Ocean, City and Fire Works Views
An absolute paradise!!! From the arrival to the attention to detail in every way, this place makes you feel right at home. We were greeted by a welcome basket even! The neighborhood is so peaceful… plenty to enjoy and relax just being at the home. We cannot wait to come back!

New! Beautiful Private Casita- King Bed & Office
Really enjoyed Alberto’s place, it’s nicely tucked away and provided a nice retreat from the busy area. We were able to relax and had all of the comforts of home. We really enjoyed the comfy couch and bed which allowed us to relax after a very busy few days. Off street parking was very nice as we had a busy agenda the few days we were in town and it was nice having our car in the driveway and secure off the street. Would absolutely stay again and recommend to anyone in the area.

Cozy, Quiet and Private Backyard Studio Escape
This was the perfect Air Bnb for our honeymoon in San Diego. It was in a great area, and the location was 15 minutes from everything we wanted to do! Couldn't recommend more

Casita with private yard and separate entrance
This was the perfect place for a one night stay. It’s so close to a lot of good restaurants and stores. Also the perfect spot to stay if you’re looking for somewhere close to the observatory theater!

New (2022) North Park Abode w/ Roof Deck
BOOK IT! Aesthetically well done, extremely comfortable, perfect location. Really enjoyed my stay here for 5 days. Unit has everything you may need during your stay. Love this neighborhood, so many great restaurants and shops. Parking was always available. Space is squeaky clean and bed is comfy. Next time I’m in SD I will stay here again.

Violet Oasis | hot tub, kitchen, no dog fee!
We had an amazing little staycation over the weekend at the Violet Oasis. Extremely clean, the bed was so comfy we never wanted to leave, both parking locations easy to find and Elizabeth and Paola were super responsive. Rather than feel like we were staying at an Airbnb it felt like staying over at a friend’s place. Their passion responding to their guests, making them feel at home and providing information on what to do in the area really shows in this listing. We will be back!
Guesthouse rentals with a washer and dryer

Beautiful Private Villa walk to beach
It’s was amazing staying a Kim’s guesthouse. Felt very private and peaceful. The birds sounded so beautiful in the morning, we thought it was fake at first. The flowers just outside are beautiful. The beach within walking distance was a perfect place to play, lay out, watch the sunset and surfers. We even saw dolphins one night! Just a magical time. We will definitely come back!

Carrie’s North Park Casita, in Heart of San Diego
my wife and I had a wonderful time at Carrie's place. she thought of everything and we did not want for anything. lots of thoughtful touches throughout the Casita. when we checked in we were greeted by the cutest little white dog named Rose. she is getting on in years but was very friendly. if you need a quiet, clean, private and convenient place in San Diego you cannot go wrong with this rental. thank you Carrie for a great time. much luck to you on future rentals!

San Diego Shangri-La
This apartment is great for 2 people to enjoy the San Diego / La Jolla area. We stayed here for a full month. The apartment is very cozy and the hosts are absolutely fantastic! They have an office set up downstairs (in the garage) and work there most weekdays and occasionally on weekends, so you're not in a totally private house (you have your own entrance and space upstairs), but they are close by for questions. As is prevalent in the area our small dog was very welcome in this apartment. If you have a small dog be wary of coyotes that roam the area.

❤ Cozy Private Studio w/ WD 2 Minutes from Freeway
Wonderful stay! Home away from home! had everything I needed for an extended stay. Will be back for sure!

Law Street Retreat
Exactly as advertised and in a great location not far from the beach and boardwalk. The bikes were great for getting around as well. The bed was also very comfortable. Easily accessed and had no issues at all!

Indoor/Outdoor Sanctuary in Ocean Beach
The place was as described and Lori was responsive. Although, I did accidentally break a small plate while cleaning it. I let her know but didn't get a response. Oops! And it would have felt good hearing, "no worries it happens." Only because I felt bad. Overall, beautiful and relaxing. I'll definitely book there again when we're back to visit family!

Beautiful Historic Home and Gardens Near Downtown!
Sam's place was lovely. The house is as advertised , and well appointed throughout. The garden was tranquil, and a nice place to relax after a long day. Sam provided us with all the kids items (Stroller, Pack n play, high chair, etc.) I highly recommend this house for all things San Diego. The location and amenities can't be beat.

Cozy Coop with a View
Corey's place definitely fit the bill as a relaxing and quiet destination in San Diego. We would recommend recommend this very nice place to any one. Thanks Corey for an awesome stay.
Quick stats about guesthouse rentals in La Mesa
Total rentals
80 properties
Nightly prices starting at
$69 CAD before taxes and fees
Total number of reviews
5.2K reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with a pool
10 properties have a pool
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- Windansea Beach
- SeaWorld San Diego
- University of California San Diego
- Santa Monica Beach
- Playas Los Buenos
- San Diego Zoo Safari Park
- Balboa Park
- LEGOLAND California
- Pechanga Resort Casino
- Belmont Park
- Liberty Station
- Moonlight Beach
- Sesame Place San Diego
- Playa Popotla
- Silver Strand State Beach
- Law Street Beach
- South Mission Beach, San Diego
- USS Midway Museum
- Hillcrest
- Temecula Creek Inn
- Buccaneer Beach
- Aviara Golf Club
- Swami's Beach
- Strand Beach