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Guesthouse vacation rentals in La Mesa

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for La Mesa guesthouses

Family-friendly guesthouses

Top guest favourite
Guesthouse in South Park
4.84 out of 5 average rating, 126 reviews

Adorable San Diego Guesthouse

AlauraRating, 5 stars1 month ago
I have never stayed in South Park before. This location was so fun! Lots of little places to walk to. No issues with parking.
Guest favourite
Guesthouse in La Mesa
4.93 out of 5 average rating, 236 reviews

Fig Tree Bungalow

LaurenRating, 5 stars2 weeks ago
This place was great for our quick weekend trip. Definitely worth the price.
Top guest favourite
Guesthouse in Poway
4.92 out of 5 average rating, 138 reviews

Private Family Friendly Casita/Guesthouse

KimberlyRating, 5 stars3 weeks ago
The casita was perfect for my family! It was bigger and even nicer in person. Robert was responsive and friendly. It was very clean, and had everything you need. We would love to stay there again!
Superhost
Guesthouse in Pacific Beach
4.83 out of 5 average rating, 361 reviews

Pacific Beach Guest House With Garage and A/C

LibreRating, 5 stars1 month ago
Great location! Easy walk to beach. Nearby restaurants within short drive.
Top guest favourite
Guesthouse in Allied Gardens
4.95 out of 5 average rating, 391 reviews

The BEST NEST Clean, peaceful, private, affordable

CatalinaRating, 5 stars4 weeks ago
Love Teri’s place! Feels just like home whenever we stay there. Walking distance to Better Buzz Coffee and Vons for groceries. Everything you need is there for you to make the place feel like home away from home. Teri was a great host too, can’t recommend her enough for anyone wanting to stay in San Diego.
Top guest favourite
Guesthouse in Jamul
4.95 out of 5 average rating, 216 reviews

Retreat house. Nature, Hot Tub, Views!

JamieRating, 5 stars1 day ago
Meaghan’s place was incredible! The natural surroundings were breathtaking. This home offered outdoor amenities that we wish we had more time to enjoy. We will definitely be returning!
Guest favourite
Guesthouse in San Diego
4.93 out of 5 average rating, 191 reviews

Cosy quiet Guesthouse near SDSU

AnthonyRating, 5 stars2 weeks ago
I think this place was well worth what it was advertised. Great location host was very responsive and I will book again if I’m in the area..
Guest favourite
Guesthouse in North Park
4.88 out of 5 average rating, 110 reviews

Charming North Park Cottage

LoraRating, 5 stars2 weeks ago
We thoroughly enjoyed our short stay at Patricia’s place. The location is within walking distance of numerous restaurants and bars and is a short drive to downtown San Diego, Little Italy etc. The home was clean and comfortable and perfect for two people. I met Patricia briefly as we were leaving. She was very friendly and had we been staying longer I would’ve asked her for local recommendations. I will absolutely stay there again when I’m back in California. Thank you, Patricia!

Guesthouses with a patio

Top guest favourite
Guesthouse in North Park
5 out of 5 average rating, 20 reviews

Golden Hour Guesthouse

MatthewRating, 5 stars1 week ago
Cara and Erik are excellent hosts with fantastic hospitality. In terms of the Airbnb itself, it was amazing and I would definitely stay there again. So much room, so well maintained— you can see immediately how serious Cara and Erik take hosting. The location makes it so easy to go to fantastic restaurants and bars, and is close everything you’ll need. Again, I cannot stress how much i enjoyed my stay and couldn’t recommend Cara and Erik more!
Top guest favourite
Guesthouse in Talmadge
4.99 out of 5 average rating, 202 reviews

Adorable cottage in Talmadge

CaitlinRating, 5 starstoday
I absolutely loved my stay in the cottage! Everything was clean and the space felt roomy, with lots of storage. I appreciated all of the recommendations Carlos provided for attractions/dining. I will definitely be back!
Top guest favourite
Guesthouse in La Mesa
4.99 out of 5 average rating, 106 reviews

Private 1 BR Paradise retreat

GinaRating, 5 stars1 week ago
Great stay & wonderful hosts. We'll be back for sure!
Top guest favourite
Guesthouse in La Jolla
4.98 out of 5 average rating, 201 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

ElizabethRating, 5 stars2 weeks ago
This was our third time staying at Atoosa’s place and it never disappoints. The house is very clean, we love the location, and the neighborhood is so quiet. We always enjoy our stay and can’t wait to visit again soon!
Guest favourite
Guesthouse in Chula Vista
4.94 out of 5 average rating, 140 reviews

New! Beautiful Private Casita- King Bed & Office

ChrisRating, 5 stars1 month ago
Really enjoyed Alberto’s place, it’s nicely tucked away and provided a nice retreat from the busy area. We were able to relax and had all of the comforts of home. We really enjoyed the comfy couch and bed which allowed us to relax after a very busy few days. Off street parking was very nice as we had a busy agenda the few days we were in town and it was nice having our car in the driveway and secure off the street. Would absolutely stay again and recommend to anyone in the area.
Guest favourite
Guesthouse in Serra Mesa
4.95 out of 5 average rating, 101 reviews

Cozy, Quiet and Private Backyard Studio Escape

ChristineRating, 5 stars1 week ago
Everything was great but the thing that stood out the most was how CLEAN everything was. I find most airbnb hosts are not keeping their rentals as clean as I would like, but this one was spotless. Not only organized, but also bathroom and kitchen tiles, counters and floors throughout were very clean and I appreciated that so much! Stephanie also graciously offered to help with a pricing issue I encountered before booking which was very kind. The guest house is quiet and peaceful and I found the bed to be very comfortable. Very nice all around.
Top guest favourite
Guesthouse in Point Loma Peninsula
4.95 out of 5 average rating, 59 reviews

Guest house with ocean views and private deck.

KaylaRating, 5 stars2 weeks ago
Cosmin’s guest house was one of the best Airbnb experiences we’ve ever had! The location was fantastic—it was close to everything we wanted to do, had easy on street parking, and was in a quiet family friendly neighborhood. The interior was extremely clean and appeared to be created with care. The kitchen was well equipped to handle all your cooking needs, and the washer/dryer were a nice addition! My family and I enjoyed our stay and felt right at home. The view from the back deck was also an added bonus! I would highly recommend.
Guest favourite
Guesthouse in North Park
4.88 out of 5 average rating, 147 reviews

Casita with private yard and separate entrance

TayRating, 5 stars1 day ago
The stay was great overall—clean, comfortable, and just as described. The only downside was parking. It’s street parking only, and finding a spot wasn’t easy. Once you do find one, it’s best to leave your car and get around using Uber/Lyft or even walking, since it’s pretty close to the main street.

Guesthouse rentals with a washer and dryer

Guest favourite
Guesthouse in La Jolla
4.98 out of 5 average rating, 416 reviews

Beautiful Private Villa walk to beach

JessieRating, 5 stars3 days ago
I cannot say enough great things about Kim’s Villa! It is in a perfect location and I felt right at home from the moment I stepped inside. The surroundings are absolutely stunning and the bedroom especially is very cozy. Kim herself was incredibly accommodating and kind - I was enjoying my stay so much that I decided to book for another week, and Kim went above and beyond to help make that happen for me! If you’re looking for the perfect stay in La Jolla - look no further than this Villa!
Guest favourite
Guesthouse in La Jolla
4.79 out of 5 average rating, 191 reviews

San Diego Shangri La

JimRating, 5 stars1 month ago
This apartment is great for 2 people to enjoy the San Diego / La Jolla area. We stayed here for a full month. The apartment is very cozy and the hosts are absolutely fantastic! They have an office set up downstairs (in the garage) and work there most weekdays and occasionally on weekends, so you're not in a totally private house (you have your own entrance and space upstairs), but they are close by for questions. As is prevalent in the area our small dog was very welcome in this apartment. If you have a small dog be wary of coyotes that roam the area.
Superhost
Guesthouse in Alpine
4.97 out of 5 average rating, 325 reviews

La Casita Private Resort Spa and Mini Golf Course

JuliaRating, 5 stars4 weeks ago
A beautiful setting & lovely guest house with charming decor. I prefer a no-host/no deadline check-in, especially as we were driving down from Los Angeles on a Friday afternoon, a 2.5-hour drive that took 5 hours -- and I was sweating that deadline the whole way. I was prepared for it, but ... The place could use a bit of maintenance/professional cleaning -- found a sock and dog bone under the bed, indicating that it hadn't been swept under there. The water seemed low in the Jacuzzi when we got in and an unpleasant foam formed almost immediately upon entry. Was not clear that it had been cleaned (or how well it had been cleaned) before our arrival. The host did warn us to watch our footing & heads while traversing the property, but the planking to the Jacuzzi and elsewhere, as well as hand-holds on railings, should be attended to. Wifi was weak/unreliable. Wasn't crazy about freeway noise either. All that having been said, it's a gem of a place that just needs updated TLC.
Guest favourite
Guesthouse in Rancho Penasquitos
4.93 out of 5 average rating, 102 reviews

❤ Cozy Private Studio w/ WD 2 Minutes from Freeway

JenniferRating, 5 stars5 months ago
Wonderful stay! Home away from home! had everything I needed for an extended stay. Will be back for sure!
Superhost
Guesthouse in Pacific Beach
4.78 out of 5 average rating, 389 reviews

Law Street Retreat

MarissaRating, 5 stars3 weeks ago
Exactly as advertised and in a great location not far from the beach and boardwalk. The bikes were great for getting around as well. The bed was also very comfortable. Easily accessed and had no issues at all!
Superhost
Guesthouse in Ocean Beach
4.88 out of 5 average rating, 321 reviews

Indoor/Outdoor Sanctuary in Ocean Beach

ShonnaRating, 5 stars3 weeks ago
The place was as described and Lori was responsive. Although, I did accidentally break a small plate while cleaning it. I let her know but didn't get a response. Oops! And it would have felt good hearing, "no worries it happens." Only because I felt bad. Overall, beautiful and relaxing. I'll definitely book there again when we're back to visit family!
Top guest favourite
Guesthouse in Mission Hills
4.97 out of 5 average rating, 248 reviews

Beautiful Historic Home and Gardens Near Downtown!

PeterRating, 5 stars1 week ago
Sam's place was lovely. The house is as advertised , and well appointed throughout. The garden was tranquil, and a nice place to relax after a long day. Sam provided us with all the kids items (Stroller, Pack n play, high chair, etc.) I highly recommend this house for all things San Diego. The location and amenities can't be beat.
Guest favourite
Guesthouse in La Mesa
4.96 out of 5 average rating, 198 reviews

Cozy Coop with a View

CindyRating, 5 stars1 week ago
Perfect! Centrally located from where we needed to be and to downtown and attractions. Spotless clean, perfect size, comfy bed and couch, kitchen with everything we needed for light cooking, big bathroom and washer and dryer! Quiet neighborhood, a few dogs barking but nothing that bothered us. Highly recommend and would stay again! Thanks for sharing your adorable little house with us!

Quick stats about guesthouse rentals in La Mesa

  • Total rentals

    80 properties

  • Nightly prices starting at

    $69 CAD before taxes and fees

  • Total number of reviews

    5.2K reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with a pool

    10 properties have a pool

Destinations to explore