Vacation rentals in La Mesa District

Beachfront Family EcoParadise to Coiba lsl BunkBed

Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Serena Lodge & Camping - The Cope

Escape to Serena Lodge, a cozy mountain cabin tucked among pine trees in El Copé, Panama. Wake up to birdsong, stunning valley views, and total privacy—just minutes from waterfalls (Las Yayas, Tigrero, Santa Maria, El Harino river, Rio Grande, Chorro Grande) and the Omar Torrijos National Park. Perfect for couples, families, friends, remote workers and nature lovers seeking fresh air, and a true disconnect in the mountains. 🌧️ Rainy Season (May–November) ☀️ Summer Season (December–March) por

North Villa with Rooftop. Full Kitchen!

Fly / Drive - Tour Coiba - Relax at the North Villa! The North Villa has plenty of space. The rooftop patio has furniture, a bar and is perfect for star gazing and birdwatching. Your villa comes with ample bedrooms, fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, charcoal grill, covered parking and dedicated Internet. We offer a free ground shuttle if you fly into the local airstrip. Feel free to message us and learn how to skip the 6hr+ drive!

Private Villa & Pool, in Lago Bay, Santa Catalina

A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Eco-friendly apartment with treehouse feeling

Beautiful open-air 2BR/2BA apartment with large kitchen patio and wraparound terrace, located on the top floor of our cozy villa, tucked away in the treetops with a view of our tropical permaculture garden. This is a unique homestay, centrally located in Sta Catalina, walking distance from beaches, several surfspots, shops, restaurants and bars. Perfect for eco-minded and adventurous singles, couples, friends or families looking for a natural and authentic airbnb experience.

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Casa Colibrí - modern house in the green

Casa Colibri is a beatiful, spacious home in the middle of nature and will make your stay in Santa Catalina perfect. It has a large terrace with a fantastic view into the green where you can relax and listen to the birds. The interior has a lot of natural light and stays cool during the day, in case you need to escape the tropical heat. It is the perfect place for a unique experience in this special town with your friends or family.

OCTOPUS studio

Disfruta de una experiencia con estilo en este alojamiento de encanto, ideal para pareja : acogedor, luminoso y actual . Ubicación fantastica en área privada y a unos paso del centro, playas y lugares de interés. Confortable para largas estadías y teletrabajo. Wifi gratuito, A/C. Kitchenette. Amplia terraza de madera rodeada de exuberante naturaleza, excelente para practicar Yoga y relajarse.

Sun Cabin at Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Vergara Cabin Santa Fe

Kick back and relax on this 2 acre ( 1 hectare) private mountain side property, on the Santa Maria River. Equipped with all the amenities you will need to make your stay a home away from home!