
Vacation rentals in La Mesa District
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Top-rated vacation rentals in La Mesa District
Guests agree: these stays are highly rated for location, cleanliness, and more.

"Casa Ardilla" with garden, kitchen and private bathroom
"CASA ARDILLA" is a house surrounded by greenery, very spacious and all in wood. Its tranquility and contact with nature make it unique. The house is located near "La Punta", the famous wave of Santa Catalina, just a 3-minute walk away. Very close to the house there is the possibility of eating in several restaurants and enjoying a delicious ice cream in the ice cream parlor "La Moncheria". The house has its own bathroom with a hot water shower, a large and equipped kitchen and a very special balcony.

Beachfront Family EcoParadise to Coiba lsl BunkBed
Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

North Villa with Rooftop. Full Kitchen!
Fly / Drive - Tour Coiba - Relax at the North Villa! The North Villa has plenty of space. The rooftop patio has furniture, a bar and is perfect for star gazing and birdwatching. Your villa comes with ample bedrooms, fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, charcoal grill, covered parking and dedicated Internet. We offer a free ground shuttle if you fly into the local airstrip. Feel free to message us and learn how to skip the 6hr+ drive!

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains
Hermosa cabaña de dos habitaciones y dos baños , den panorámico ubicada a unos 50 minutos de Penonome, Provincia de Cocle, en el Area del Parque Nacional Omar Torrijos Herrera , temperaturas entre 22 y 25 grados C a orillas del turístico Chorro de las Yayas en la comunidad de Barrigon del Cope, distrito de La Pintada. Agradable ambiente rodeado de árboles frutales y hermosas cascadas. Ideal para disfrutar de la naturaleza y relajarse. Cuenta con internet satelital de rápida velocidad .

Country House in Olá, rivers, waterfalls, Los Picachos
Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Private Villa & Pool, in Lago Bay, Santa Catalina
A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Eco-friendly apartment with treehouse feeling
Beautiful open-air 2BR/2BA apartment with large kitchen patio and wraparound terrace, located on the top floor of our cozy villa, tucked away in the treetops with a view of our tropical permaculture garden. This is a unique homestay, centrally located in Sta Catalina, walking distance from beaches, several surfspots, shops, restaurants and bars. Perfect for eco-minded and adventurous singles, couples, friends or families looking for a natural and authentic airbnb experience.

Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Santiago city, home w/ spacious living & office
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Casa Colibrí - modern house in the green
Casa Colibri is a beatiful, spacious home in the middle of nature and will make your stay in Santa Catalina perfect. It has a large terrace with a fantastic view into the green where you can relax and listen to the birds. The interior has a lot of natural light and stays cool during the day, in case you need to escape the tropical heat. It is the perfect place for a unique experience in this special town with your friends or family.

OCTOPUS studio
Disfruta de una experiencia con estilo en este alojamiento de encanto, ideal para pareja : acogedor, luminoso y actual . Ubicación fantastica en área privada y a unos paso del centro, playas y lugares de interés. Confortable para largas estadías y teletrabajo. Wifi gratuito, A/C. Kitchenette. Amplia terraza de madera rodeada de exuberante naturaleza, excelente para practicar Yoga y relajarse.

Sun Cabin at Finca Namuiki by the River
Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.
Popular amenities for La Mesa District vacation rentals
Other great vacation rentals in La Mesa District

Comfortable and safe apartment in downtown Santiago

Exclusive cabin with Jacuzzi and unforgettable landscape

Country house, La Mismísima

Secret Garden House

Cabin with river view

Cabin overlooking Picachos Olá. Near rivers and waterfalls

Mountain retreat with hot tub and farm views

Casa Palma
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