Vacation rentals in Santa Fe Lake

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Top-rated vacation rentals in Santa Fe Lake

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Top guest favourite
A wooden dock extends over the water towards a two-story house, featuring a spacious patio with seating. The grassy area around the house is shaded by trees draped in Spanish moss, contributing to a serene outdoor environment.
Home in Waldo
4.97 out of 5 average rating, 32 reviews

Lake Santa Fe House Amazing Views Sunrise Sunset

Come make memories for a lifetime on Santa Fe lake in Earleton . This a great place to stay for Gator events with a 20 minute commute. The house is in a paved neighborhood for walking or biking. Enjoy beautiful sunrises and sunsets with your unobstructed lake view . The house is comfy and cozy for the whole family to come enjoy. Whether you are into water sports, fishing, or just want a nice quiet getaway this place offers it all. Right on lake, with your own private boat ramp, dock and beach

Top guest favourite
A collection of colorful kayaks and canoes rests along the shoreline of Lake Mable. A wooden dock extends into the calm water, surrounded by lush greenery in the background. The clear blue sky overhead reflects softly on the lake's surface.
Home in Melrose
4.92 out of 5 average rating, 143 reviews

Three Bedroom House on Private Scenic Lake Mable

Located on pristine (no gas engines) swimming and fishing Lake Mable, this cheerful home is the perfect spot for a fun filled family vacation or just a relaxing weekend getaway. Enjoy the peaceful sounds of nature as you sit and watch the sunset over the lake, roast some marshmallows over the firepit, or just relax by the lake with a fishing rod in hand. You may see Sandhill Cranes, Red-headed Woodpeckers, or even a few deer. Let your worries drift away and enjoy the tranquility around you.

Guest favourite
Two comfortable chairs are positioned on a wooden deck overlooking a calm lake, surrounded by a serene landscape. The expansive water reflects a blue sky, creating a peaceful atmosphere for relaxation and enjoyment.
Home in Melrose
5 out of 5 average rating, 22 reviews

Modern LAKE HOUSE on Lake Santa Fe near Gville/UF

Have fun OR relax at this fully renovated LAKE HOUSE w/BOATHOUSE and raised sunset deck only 30 mins to Gainesville! Sit back and and enjoy the beautiful views of the lake as soon as you enter the home or up close from the hammock swings in the boat house! 3 BR/2 BA plus converted air conditioned garage used as a game room with Ping Pong Table and TV, easily sleeping 8. The backyard offers a large deck with privacy fencing and lush landscaping with direct access to step right into the lake.

Top guest favourite
A charming log home is nestled among large trees draped in Spanish moss, with a well-kept grassy area leading to the lake. The porch is visible, and the peaceful water serves as a backdrop, enhancing the natural beauty of the surroundings.
Cabin in Hawthorne
4.97 out of 5 average rating, 173 reviews

Charming Lakefront Log Home

Welcome to your perfect lake retreat! Located on a no public access lake. This charming log home has a private dock and boat ramp suitable for launching your boat for fishing or skiing. There are kayaks on premises for use. This is an ideal location to enjoy North Florida’s lake life with family, friends, or work retreat. Includes a fully stocked kitchen, covered porch, fire pit, gas grill, and WiFi if you feel the need to plug in. NOT suitable for parties or events. NO loud noise, please.

Top guest favourite
A serene lakeside view features vibrant pink flowers and lush greenery framing a hammock. The calm, clear waters of the private lake are visible in the background, with two kayaks resting on the shore, creating an inviting space for relaxation.
Cottage in Hawthorne
4.97 out of 5 average rating, 200 reviews

Modern Cottage on Private Spring Fed Lake

Nestled on a gorgeous spring-fed private lake in the woods, our charming cottage is your ideal retreat. Whether you're dreaming of peace and quiet, a romantic getaway, or fun with your kids, this is the place to be! Kayak around the serene lake as you witness breathtaking sunsets, take a dip in the cool water or simply unwind amidst the beautiful surroundings. As night falls, gather around a fire and gaze up at the many stars lighting the sky. Come and create many cherished memories ☀️

Top guest favourite
A modern kitchen features light cabinetry paired with dark lower units. A double sink is positioned beneath a window, allowing natural light. The turquoise tile backsplash adds a pop of color. Open shelving displays dishes, and a stainless steel stove is visible.
Apartment in Melrose
4.89 out of 5 average rating, 230 reviews

The Orchid of Lake Santa Fe

Melrose Bay on Lake Santa Fe This apartment is newly remodeled. It features new cabinets, new appliances, a private porch and lovely furnishings, WIFI and cable. Downtown Melrose is in walking distance with three restaurants (one is the famous Blue Water Bay), public library, post office, grocery store, dollar store and Ace. Bring your boat and launch at the nearby boat ramp. Lake Santa Fe is a recreational lake with clean spring fed water for swimming, boating, skiing and fishing.

Guest favourite
A quaint cottage with blue exterior is shown, featuring a covered porch with a wooden walkway. The entrance is accented by large windows and a charming sign. Lush greenery surrounds the property, complemented by a clear blue sky above.
Cottage in Earleton
4.94 out of 5 average rating, 36 reviews

Lake Santa Fe Cottage Get Away (1 Room Studio)

Cozy, quiet space to relax and enjoy beautiful Lake Santa Fe. Perfect for a 2-3 day getaway. Spacious 1 room, 1 bath lakeside studio cottage at the historic former Buddy's Landing site on Lake Santa Fe in Earleton. Private and gated with direct lake access. A peaceful, quiet space to unplug and get away from the daily chaos. Use of the private boat launch for a small additional fee ($20). (Currently 6 cottages for rent. Perfect for multiple families to hang together on the lake!).

Top guest favourite
A wooden boardwalk leads to a gazebo on the water’s edge, surrounded by a calm lake reflecting warm colors from the sunset. Grass borders the walkway, creating a serene atmosphere for relaxing by the water.
Home in Hawthorne
5 out of 5 average rating, 23 reviews

Private Lakefront Retreat Near Gainesville UF

Escape to Monkey Business - your peaceful, serene, waterfront getaway on beautiful, private, Cowpen Lake! Nestled just outside Gainesville, in Hawthorne, this cabin offers everything you need to unplug, unwind, and reconnect with nature. Whether you're sipping coffee on the screened-in porch, casting a line from the private dock, or boating or paddling in the lake, every detail invites you to slow down and enjoy the moment. Great fishing, tranquil views, and cozy cabin vibes await!

Top guest favourite
Dome in High Springs
5 out of 5 average rating, 5 reviews

Soluna GeoDome 2: Stargazing, Springs, Outdoor Tub

Check out our latest handcrafted geodome creation. Tucked into the trees at Soluna Springs, 3 min to Poe, 5 min to Blue, and 12 min to Ginnie Springs, our geodome has everything you need to stay comfortable while being close to nature, and nothing you don’t. Rest on our King organic Birch mattress, stargaze while soaking in our outdoor tub, take a hot outdoor shower after the sauna, fire up the charcoal grill and fire pit, and sit back and relax. This isn’t a hotel. Its a reset.

Top guest favourite
A figure glides across the water at sunset, creating ripples in the smooth lake surface. The sun casts a golden reflection, enhancing the serene ambiance. Soft clouds are visible in the sky, adding depth to the tranquil scene.
Cottage in Melrose
4.99 out of 5 average rating, 102 reviews

The Nest on Lake Santa Fe in Melrose, FL

The Nest is a beautiful two-story cottage on Lake Santa Fe. Enjoy some peace and serenity, catch monster bass, or bring your ski boat for high-speed fun. We are located just 20 minutes from Gainesville and UF. The Nest is great for a weekend getaway or a week of peaceful relaxation. We do not allow parties or events out of respect for our neighbors and we allow a maximum of 6 guests (max 4 adults). Absolutely no animals are allowed on the property at any time for any reason.

Guest favourite
Cabin in Trenton
4.92 out of 5 average rating, 24 reviews

Cozy A-Frame: Hand-Feed Animals on 800-Acre Farm

Escape the ordinary in our stunning A-frame nestled on a massive 800-acre working farm. This isn't just a stay; it’s an immersive wildlife adventure! Wake up to the sights of over 200 animal species right outside your door. From morning coffee to sunset strolls, you’ll have the unique chance to hand-feed and get up close with our friendly residents. Perfect for nature lovers and families seeking a rustic yet magical retreat. Book your unforgettable farm-stay safari today!

Guest favourite
An open and airy dining area is showcased with a wooden table surrounded by upholstered chairs. A contemporary ceiling fan is positioned overhead, while natural light pours in through expansive windows, illuminating the space and highlighting the modern decor.
Home in Melrose
4.97 out of 5 average rating, 38 reviews

Lakefront Haven w/ Pool!

Discover the historic town of Melrose, FL! This exquisite 4 bedroom 3.5 bathroom residence is idyllically situated along the serene Lake Santa Fe, granting you exclusive access to its tranquil waters. Whether you're a couple seeking a romantic getaway or a family in search of a memorable vacation, this home has it all. With the vibrant city of Gainesville just a short 30-minute drive away, the possibilities for adventure and entertainment are limitless.

Popular amenities for Santa Fe Lake vacation rentals

  1. Airbnb
  2. United States
  3. Florida
  4. Alachua County
  5. Santa Fe Lake