
Hotel vacation rentals in Mission Bay
Find and book unique hotels on Airbnb
Top-rated hotels in Mission Bay
Guests agree: these hotels are highly rated for location, cleanliness, and more.
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Vacation rentals for every style
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Popular amenities for Mission Bay hotels
Family-friendly hotels

Resort in Coronado
5 out of 5 average rating, 10 reviewsCoronado Beach Resort
StaciaRating, 5 stars10 months ago
This place is amazing. There are so many amenities to help you enjoy your vacation. We utilized the free beach chairs, umbrellas, and boogie boards the hotel offers as well as the day passes to Loews. The beds are comfortable. The small kitchen area is perfects for snacks and light cooking. There was a great balcony. The staff was amazing there as well. The location is right where you want to be. Surrounded by great restaurants and a very short walk to the beach. We would definitely stay again!!!

Hotel room in Tijuana
5 out of 5 average rating, 4 reviewsHobbit
EduardoRating, 5 stars51 months ago
Awesome place. I love the layout and location .

Private room in San Diego
4.63 out of 5 average rating, 54 reviewsPrivate Room in Hostel by the Beach, 2 Double Beds
MarkRating, 5 stars31 months ago
Great location for a hostel, just a few steps from the beach! We’ll maintained as well and clean for a hostel! You’ll meet fun people, enjoy!
Superhost

Hotel room in Carlsbad
4.76 out of 5 average rating, 45 reviewsLuxury Villa #6550 at Omni's La Costa Resort & Spa
MdcRating, 5 stars9 months ago
Great place! Looking forward to next time...will recommend to my contacts.

Hotel room in Chula Vista
4.29 out of 5 average rating, 14 reviewsHoward Johnson By Wyndham San Diego Chula Vista
MasonRating, 5 stars9 months ago
Stayed here during SDCC for a couple days. Price was solid especially for comic con. The check in host was very nice and helpful. Overall I would say it was a typical lower budget hotel stay. Nothing fancy by any means but it got the job done for what I needed!
Superhost

Hotel room in San Diego
4.87 out of 5 average rating, 177 reviewsGaslamp 2BdRm - w Parking & 5 Beds #303
KhalilRating, 5 stars1 month ago
This airbnb was right in the heart of Gaslamp if you want a fun weekend getaway this is the best spot for it. The open living room and natural sunlight was great. Beds were super comfortable. The host was very responsive and answered the phone 100% of the time and very friendly. Would definitely book again.
Hotels with a pool

Hotel room in San Diego
5 out of 5 average rating, 4 reviewsStylish San Diego downtown Suite
JoyRating, 5 stars2 months ago
Thank you! The double room suite had plenty of room for our 4. It was clean and close to the theater. It was everything we needed. Easy check in and friendly staff. Thank you!

Hotel room in San Diego
New place to stayIconic Resort in San Diego
PrisillaRating, 5 stars4 weeks ago
Great stay.

Hotel room in San Diego
4.47 out of 5 average rating, 59 reviewsSoothing neutrals & killer coastline location
HaileyRating, 5 stars1 week ago
Beautiful location and wonderful suite, will definitely plan a stay again!

Hotel room in San Diego
4.37 out of 5 average rating, 19 reviewsPlayful escape near games & concerts at Petco Park
MathewRating, 5 stars4 months ago
Great stay will definitely return to this location.
Hotels with a patio

Private room in San Diego
5 out of 5 average rating, 3 reviewsOhana House
ToscaneRating, 5 stars1 day ago
The listing is a good fit. We had a nice weekend there. It has a fairly central square in San Diego which allows you to visit the city without going too long.

Shared room in San Diego
4.6 out of 5 average rating, 10 reviews1 Bed in a 6 Bed Dorm near San Diego Airport
BrandonRating, 5 stars4 weeks ago
It was a nice stay. They were always attentive and felt very safe and trusted. They were also very nice and patient with my few English speaking skills😅, then showed up people who spoke Spanish, so all good.

Private room in San Diego
4.76 out of 5 average rating, 58 reviewsPrivate Queen Room With Shared Bathroom @ Hostel
AmandaRating, 5 stars2 weeks ago
Loved staying here! The hostel was so cute and cozy. Definitely recommend!
Top guest favourite

Hotel room in San Diego
5 out of 5 average rating, 38 reviewsHotel Narcissus - Room 2
BillRating, 5 stars4 days ago
This might be one of my favorite Airbnb’s. I’ve ever stayed at. I loved the entire set up of the restaurant and bar being right there in the lobby outside of my room(room 2). Benjamin was an amazing host and goes above and beyond whatever you need. He connected me to so many great restaurants nearby but none of them were better than the meals I had from Chef Eddie at Alchemy/Choose Thy Poison. It was incredibly great food every time I dined there plus the cocktails are amazing. You park on the street which was never an issue at all. It’s also near an interstate but it honestly seems like a soothing noise maker. If I go back to San Diego, I’m going back to stay here!

Hotel room in San Diego
4.39 out of 5 average rating, 49 reviewsModern King Suite | Steps from Little Italy & Bay
KelvinRating, 5 stars2 months ago
Actually, everything was perfectly fine. Location was ok.. The only thing they need to improve is their communication skills. I have told the reception earlier that I aim to have a late check-out at 12pm and she said okay. However, during my check-out date, at 10am, the housekeeping staff awkwardly asked me again when I'll check-out..
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