
Hotel vacation rentals in Mission Bay
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Top-rated hotels in Mission Bay
Guests agree: these hotels are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Mission Bay hotels
Family-friendly hotels

Stylish San Diego downtown Suite

Ocean Beach - Bed in 6-Bed Female Dorm

Soothing neutrals & killer coastline location

Stylish South Bay Home

Pet-friendly Hotel with Free Breakfast and Pool!

Equipped with the essentials

Ocean Beach - Bed in 6-Bed Mixed Room

3BR Suite w/ Event Space & Resort Amenities Sleep8
Hotels with a pool

Recently reno’d escape near the Gaslamp Quarter

Convenient Base Near San Diego Zoo & Balboa Park

Marriott At San Diego - Studio

Iconic Resort in San Diego

San Diego Stay w/ Pool + Free Airport Shuttle

Playful escape near games & concerts at Petco Park

1-Bedroom Hotel Suite - 2 beds

Free B’fast & Parking – Minutes to Pacific Beach
Hotels with a patio

Coronado Beach Resort July 6-13

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

San Diego 2 Queen Suite City View w/ Breakfast

Charming 1 bedroom resort steps away from beach

Comic-Con 2026: Spacious King Suite + Sofa Bed
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