
Vacation rentals in Murphysboro
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Top-rated vacation rentals in Murphysboro
Guests agree: these stays are highly rated for location, cleanliness, and more.

Beautiful Cabin close to SIU/wineries/Shawnee
Beautiful cabin sitting in the middle of woods w/ a large entertaining deck that makes you feel like are " away from it all" even though you are 3 mins away from SIU! Features 4 bedrooms & 2 full baths with an open floor plan with plenty of room for family and friends! Enjoy the large deck to grill or to just enjoy a glass of wine from one of our local wineries. Large master suite with jacuzzi tub to unwind. Make use of the concrete party pad with firepit & bar/ game room. Location is perfect!

Ma's Cabin, Alto Pass, IL. Fine country lodging.
Cute and country remodel done in 2019. Recent new appliances, furnishings, flooring, heat & A/C, washer & dryer. Cabin is secluded and quiet plus 1/2 mile from Alto Pass Lookout Point and right in the middle of many award-winning wineries. 15 miles from Carbondale 4 miles from Giant City 30 miles from Garden of the Gods 6 lakes within 10-mile radius Hundreds of miles of hiking trails in nearby Shawnee National Forest 6 miles from Bald Knob Cross Please, no dogs! No smoking in cabin!

Homestead Cottage
Enjoy tiny farmhouse life in this adorable 375 sq. foot cottage. Loaded with everything you need this little cottage is nestled privately behind some trees on our 11 acre farm. You will soon forget how close you are to town with the beautiful view from your windows and the pasture fence just steps out the back door. Whether you’re here for the wineries, amazing hiking, an SIU event (3 miles) or to visit with family, the Homestead Cottage will provide a comfortable retreat from any adventure.

Artist Vibe on the SI Wine Trail. New Kitchen!
What makes The Loft truly unique is its location. At the start of the S.I. Wine Trail, the cabin is just minutes to Cedar Lake, 15 minutes from nationally award winning BBQ, delicious ice cream, shopping, and fun of all sorts! On a 70 acre organic farm, the cabin is tucked into a breathtaking valley next to the Shawnee National Forest and has a gourmet kitchen and is filled with antiques, games & play space, original eclectic artwork, plus toddler gear so you can travel light! You’ll love it!

Embers of Murphysboro
Escape to the beauty of Embers of Murphysboro. The sprawling landscapes and cabin with high end amenities have everything to offer for a weekend getaway or larger gathering. Sucumb to the beauty of nature around you that will awaken your inner senses and relax your mind. Nestled upon a 26 acre property the cabin will astound you with picturesque landscapes and a lodging infused with both character and luxury. Explore local wineries, hiking trails, fishing, boating , dining and more...

Modern Cabin at Trillium Ridge
Tucked into the rolling hills of the Shawnee National Forest, our modern cabin offers a welcoming retreat where comfort and nature meet. Wander down a private trail to explore or climb at the Holy Boulders, or take an easy drive to local wineries and see the iconic sights of Little Grand Canyon, Inspiration Point, and Pomona Natural Bridge. When you’re ready to slow down, return to soak in the hot tub, unwind in the sauna, and settle into our cabin made for rest and connection.

Cedar Lake Retreat A
Enjoy a quiet, peaceful, pet-friendly retreat, less than a mile from Cedar Lake boat ramp/kayak launch and Poplar Camp Beach. This cute and comfy duplex is less than 6 miles from Giant City State Park, located in Shawnee National Forest, and just 4 miles from Southern Illinois University-Carbondale. Enjoy fishing, kayaking, and rock-climbing, or hit the Shawnee Wine Trails. If you’re a nature buff or you’re in town for SIU festivities, this is the place for you.

Panthers Inn Treehouse
Come nestle amongst the leaves at Panthers Inn Treehouse. This secluded, well equipped, elevated cabin has the perfect combination of natural beauty and artful luxury. Isolated yet conveniently located 2 minutes from Blue Sky and Feather Hill wineries, within 5 minutes of Panthers Den hiking trail and the Shawnee Hills canopy tour and only 10 min from I-57 exit 40. Panthers Inn is the perfect starting and ending point to your Shawnee Hills Wine Country vacation!

Relaxing 3 Bedroom Cottage in Quiet Neighborhood
This happy 3 bedroom duplex will be a family favorite on your next trip to Southern Illinois. You'll enjoy 3 cozy bedrooms each equipped with a TV, 1 bathroom, ample deck space and firepit. We are located on a quiet street within walking distance of all Carbondale has to offer – Downtown Carbondale, restaurants and pubs (.8 miles), the Memorial Hospital of Carbondale (.5 miles), Carbondale Civic Center (.8 miles), Amtrak Station (.9 miles), and SIU (1.1 miles).

2 Bed 1.5 Bath Condo
We have a newly renovated 2 bedroom, 1.5 bath condo with WIFI located just 2 blocks off Walnut Street. Walking distance or just a short drive to many locally owned shops, restaurants, wine trails, lakes (both Kinkaid and Murphysboro lakes), SIU and breweries. Queen beds and TV's with Roku in both bedrooms. USB charging ports in both bedrooms.

Modern Queen Suite Near SIU Carbondale
Stay in Suite 3 at Wall Street Suites, a modern queen suite near SIU Carbondale. This newly renovated micro-suite blends industrial charm with stylish urban design. Enjoy a full kitchen, Smart TV, queen bed & updated bath, plus a shared lobby workspace. Perfect for mid-term or monthly stays near SIU East Campus. Note: Access via stairwell.

Country Club Road Getaway
Freshly remodeled!! Conveniently located between Murphysboro and Carbondale. Whether your stay is short or long term this getaway is comfortable and very practical with amenities such as kitchen, laundry, garage, and even a walk-in closet. Just down the road from Jackson County Country Club golf course.
Popular amenities for Murphysboro vacation rentals
Other great vacation rentals in Murphysboro

2 Bedroom country craftsman

Charmful Cabin Artist respite next to refuge

Vulture's Roost at the Iconic Makanda Boardwalk

Lakefront Woodland Wonderland—Shawnee NF—ILOzarks

The Lab! Come stay in our brand new space.

Gram's Cabin at Bald Knob

Cozy Ranch on Brookside/Serene Country Getaway

Koopers Landing Treehouse
Frequently Asked Questions
Are there family-friendly house rentals in Murphysboro?
Murphysboro has more than 10 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
How much does it cost to stay in house rentals in Murphysboro?
Experience the best of Murphysboro with our house rentals, starting at about $80 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there pet-friendly vacation rentals in Murphysboro?
Four-legged friends are welcome in Murphysboro. Choose from more than 10 vacation rentals for guests traveling with pets.
Are there vacation rentals with a dedicated workspace in Murphysboro?
Yes! Work meets play with ease at over 10 vacation rentals in Murphysboro featuring dedicated workspaces. Stay connected and productive in your home away from home.
Do house rentals in Murphysboro have air conditioning?
Absolutely! We offer over 10 house rentals with air conditioning in Murphysboro. Enjoy a tailored experience with all the comforts you desire.
Do house rentals in Murphysboro have a kitchen?
Absolutely! We offer over 10 house rentals with a kitchen in Murphysboro. Enjoy a tailored experience with all the comforts you desire.
Do house rentals in Murphysboro have wifi?
Absolutely! We offer over 10 house rentals with wifi in Murphysboro. Enjoy a tailored experience with all the comforts you desire.
Do house rentals in Murphysboro have free parking?
Absolutely! We offer over 10 house rentals with free parking in Murphysboro. Enjoy a tailored experience with all the comforts you desire.
Quick stats about vacation rentals in Murphysboro

Total vacation rentals
Explore 30 vacation rentals in Murphysboro

Nightly prices starting at
Murphysboro vacation rentals start at $41 CAD per night before taxes and fees

Verified guest reviews
Over 1,340 verified reviews to help you choose

Family-friendly vacation rentals
20 properties offer extra space and kid-friendly amenities

Pet-friendly vacation rentals
Find 10 rentals that welcome pets

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wifi availability
20 of Murphysboro vacation rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Murphysboro rentals

4.8 Average rating
Murphysboro stays are highly rated by guests—averaging 4.8 out of 5!
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