Guesthouse vacation rentals in National City

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouses in National City

Guests agree: these guesthouses are highly rated for location, cleanliness, and more.

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Top guest favourite

Guesthouse in Mission Hills

5 out of 5 average rating, 207 reviews

Santorini-Inspired Cottage w/ Hot Tub + Views

*CHECK OUT OUR OTHER AIRBNB* Travel 16 steps up a Greek-inspired curving stairway with 2-story high walls to your tucked-away cottage built into the hillside villa of Alta Colina. With spectacular views, step onto the balcony to watch planes take off & boats sail around the harbor. End the night in front of your secluded back patio fireplace or climb the steps of your spiral staircase to the rooftop Jacuzzi. European-inspired design & details, it'll be hard to believe you’re still in San Diego!

Top guest favourite

Guesthouse in Kensington

4.97 out of 5 average rating, 594 reviews

Central & Serene Secret Garden Guesthouse

My cozy & stylish Garden Guesthouse features colorful decor that gives a fun, relaxed vibe. Relax in style inside or outside in my peaceful garden w a cup of coffee, or glass of wine. I love to say a hi to my guests yet your privacy is #1. Reach me via Airbnb app if I can help! Kensington is a central, 1920’s historic neighborhood w shops & great local eateries. Close to downtown, Gaslamp, Zoo, airport, beaches, Balboa Park. Bus stop, & trolley nearby. Reserved off street parking space too!

Guest favourite

Guesthouse in San Diego

4.91 out of 5 average rating, 103 reviews

Casita Daisy: Fully Equipped 1BR Home in San Diego

Your Home Away from Home Casita Daisy. Equipped with high speed Wi-Fi, private patio, AC, and Pet-Friendly. Includes a full-equipped kitchen, private bedroom, comfortable living space, and 1-driveway parking. Casita Daisy is centrally located: - 20 mins/ 11 mi. > San Diego Airport & Downtown San Diego - 1 hr > mountains and deserts - 30 mins/15 mi. > Mexico Border - 25 mins/14 mi. > Sea World - 15 mins/8 mi. > San Diego Zoo - 40 mins/35 mi. > San Diego Zoo Safari Park Long term stays welcome.

Superhost

Guesthouse in Chula Vista

4.93 out of 5 average rating, 152 reviews

New! Beautiful Private Casita- King Bed & Office

Relax in this welcoming brand new casita featuring: ✓ Private side entrance with a keypad ✓ Modern kitchen fully equipped with cooking essentials ✓ Stocked coffee/tea bar with locally roasted coffee ✓ 1 bedroom with a comfy King size bed and smart TV ✓ 1 bath with essentials ✓ Separate office space, including monitor, keyboard, & fast internet, perfect for remote workers! ✓ In-unit washer/dryer, pods & dryer sheets provided ✓ Cozy outdoor living space ✓ Parking for 1 vehicle in the driveway

Superhost

Guesthouse in National City

4.86 out of 5 average rating, 160 reviews

Private Pet-Friendly Studio w/Parking Near Gaslamp

Escape to this cozy, private back-studio, perfect for couples! Located just 4 miles from San Diego’s lively Gaslamp District, this studio offers a peaceful retreat in a safe neighborhood. Enjoy hassle-free parking and a fenced space with a private entrance through the side gate—no face-to-face contact. Fenced yard perfect for pets to play safely, plus nearby dog-friendly beach. Whether you’re here to explore downtown, relax in comfort, or visit Coronado, this studio is your ideal getaway!

Superhost

Guesthouse in Sherman Heights

4.87 out of 5 average rating, 158 reviews

Downtown Cottage Minutes to Gaslamp & Petco Park

Welcome to your urban cottage just steps away from downtown San Diego! The Queen Anne Cottage combines brand-new renovations with historic charm. The Cottage has a private entrance so you can easily come and go and is located in quiet, family-oriented neighborhood in the Sherman Heights historic district just a few blocks from downtown San Diego. It is minutes away from the Convention Center, Petco Park, the Gaslamp District, the Coronado bridge, Balboa Park, and the San Diego Zoo.

Guest favourite

Guesthouse in San Diego

4.96 out of 5 average rating, 380 reviews

Betty- Guesthouse near CBX & San Ysidro border

This comfy studio located in San Diego is the perfect spot for a quiet & cozy weekend retreat. Inside is bright & inviting with stylish spacious studio, private entrance from side gate, private patio with bbq & hanging hammocks; driveway parking spot & plenty of street parking! The view from the patio is very relaxing, making it the perfect weekend get away. Centrally located in a quiet & peaceful area within 5 minutes away from Plaza Las Americas & 10 minutes away from the CBX.

Top guest favourite

Guesthouse in Kensington

5 out of 5 average rating, 129 reviews

Private Studio in Walkable Kensington Neighborhood

Private studio apartment w/parking & private entrance. Located in a quiet pocket of the trendiest area in central San Diego in the Kensington neighborhood. Amenities include blackout roller shades, heat/AC, full kitchen, 300 mbps wifi, private patio, parking. Next to the lively neighborhoods of Normal Heights/North Park and close to Hillcrest & Balboa park. Walking distance to cafés, breweries, restaurants, & local grocery store. Hit up the beaches (8 miles) and downtown (4 miles).

Top guest favourite

Guesthouse in National City

4.96 out of 5 average rating, 181 reviews

Trendy 1 BR Guesthouse. Great views, no chores.

This is a beautiful 1 bedroom guest house with a full-size bed and full-size sofa bed. It is close to everything, making it easy to plan your visit. AirPort, Downtown, Coronado, Balboa Park, local beaches, Mexico, and Navy bases are just a few minutes' drive. Private on-site parking. Charge your EV on site. 110v or 220V Don't waste precious time on charging stations. Public transportation as well as plenty of shopping and restaurants within walking distance.

Top guest favourite

Guesthouse in San Diego

4.96 out of 5 average rating, 121 reviews

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV

This is the perfect Guest House with a salted & heated pool & hot tub. We are located in a super quiet & very safe neighborhood in beautiful San Diego, 15 minutes drive to Downtown, La Jolla, Beaches, Zoo, Sea World & Convention Center. Hike next door at Mission Trails & Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo and top quality finishes await you inside. Everything you need for memorable vacation! No smoking or vaping on the property.

Guest favourite

Guesthouse in Greater North Park

4.95 out of 5 average rating, 255 reviews

California Cottage in North Park

Walking along side the main house into this secluded cottage, you’ll embark on your own vacay just 10 minutes from the airport. This converted separated garage is a home away from home with walking distance to University Ave with Communal Coffee for breakfast, and outdoor dinner dinning at Louisiana Purchase. If the zoo is what you desire, it is not a far walk but a little hike through the canyon is required.

Top guest favourite

Guesthouse in Adams North

4.99 out of 5 average rating, 437 reviews

Mountain View Retreat in Gated Estate (Hot Tub)

Perched above a canyon with spectacular panoramic mountain views, this private guest house is a secluded retreat in one of San Diego’s most eclectic and desirable neighborhoods less than 6 miles from the Downtown San Diego airport. Enjoy a fully equipped kitchen, luxe king size bed and dual sliding glass doors that open to an expansive deck with patio seating, private hot tub and BBQ area.