
House vacation rentals in Pickens County
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Top-rated house rentals in Pickens County
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Pickens County house rentals
House rentals with a pool

Keowee Key Luxury Condo - Stunning Views!

Lake Keowee condo by marina&pool close to Clemson

Lake Keowee Access-Dock-Pool-Grill-Clemson 17 Min

Clemson football 15 minutes away. 2 night minimum.

Historic Pendleton SC

Golf view, lake access, 3 pools!

* Keowee Key* Lake* Fireplace*Golf*Tennis*Gym*

Cottage close to Clemson
Weekly house rentals

Pickens Place Unit A

Easley Cottage: near Clemson & Greenville & Lakes

Robin’s Nest- Cottage in the Woods

Lake Keowee SC Lakehouse Escape

King Bed Quiet Modern Farmhouse w/ HUGE yard

Cozy Brick House

Respite House

Whispering Meadow Cottage
Private house rentals

Elegant 3BR Near Wed Venu | Grill+ Golf Next Door

Singing Pines Cottage

Cozy Foothills Retreat

Modern home near Clemson, Keowee

Taking it Easley/FirePit/Near Dwn GVL/HtTub/Silos

Forest Getaway 5 mins to Clemson- Private Entrance

The Llama Retreat Beautiful, Cozy Bungalow!

New! 4/3 Home In Pendleton, 10 Mins to Clemson U!
Destinations to explore
- Rentals with a patio Pickens County
- RV rentals Pickens County
- Rentals with a kayak Pickens County
- Rentals with a firepit Pickens County
- Fitness-friendly rentals Pickens County
- Rentals with a hot tub Pickens County
- Condo rentals Pickens County
- Rentals with breakfast Pickens County
- Rentals with pools Pickens County
- Waterfront rentals Pickens County
- Apartment rentals Pickens County
- Rentals with a fireplace Pickens County
- Rentals with lake access Pickens County
- Pet-friendly rentals Pickens County
- Rentals with a washer and dryer Pickens County
- Cabin rentals Pickens County
- Rentals with outdoor seating Pickens County
- House rentals South Carolina
- House rentals United States
- Blue Ridge Parkway
- River Arts District
- Black Rock Mountain State Park
- Gorges State Park
- Tugaloo State Park
- Chimney Rock State Park
- Mountaintop Golf & Lake Club
- Table Rock State Park
- The North Carolina Arboretum
- Tallulah Gorge State Park
- Tryon International Equestrian Center
- Lake Lure Beach and Water Park
- Ski Sapphire Valley
- Wade Hampton Golf Club
- Jump Off Rock
- Maggie Valley Club
- Biltmore Forest County Club
- Old Edwards Club
- Vineyards for Biltmore Winery
- Victoria Valley Vineyards
- French Broad River Park
- Woolworth Walk
- Discovery Island
- Thomas Wolfe Memorial