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Vacation rentals in Muscatine

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Muscatine

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favourite
The exterior of a two-story home features brick accents and a welcoming porch. A staircase leads to the entrance, flanked by a neatly maintained lawn. The surrounding area includes a fence for added privacy.
Home in Muscatine
4.91 out of 5 average rating, 80 reviews

La Casita Guest House

La Casita is a family freindly, fully remodeled 3 bedroom/2 bath home. We are located within a 3 minute drive to historical downtown Muscatine. The kitchen is fully equiped and the home features a king bed, a queen bed and a twin bed for use (a pack-n-play is available if requested). Other features include full tub/shower combos in each bathroom, full size washer & dryer, smoke/carbon monoxide detectors, self check in with keyless entry, wifi, smart TV, and an enclosed private backyard area.

Guest favourite
A historic four-bedroom home is captured with tall trees framing the exterior, set against a clear blue sky. The architectural features include a prominent turret and multiple windows, reflecting the home's charm. A snow-dusted yard leads to a view of the nearby Mississippi River.
Home in Muscatine
4.96 out of 5 average rating, 151 reviews

Historic West Hill Retreat

Beautiful historic 4 bedroom, 4 bath home within walking distance to shopping, bars/restaurants and all that downtown Muscatine has to offer. Enjoy sweeping views of the Mississippi River from several vantage points in and outside this home. The 3000 sf interior offers many places to gather and relax. Two of the bedrooms have on suite full baths. The other two bedrooms share a full bath. Additional amenities include, fully equipped kitchen, laundry, games, grill, outdoor entertainment area.

Guest favourite
Two Adirondack chairs face a glowing fire pit, surrounded by a grassy area. A swing set stands nearby, and the tranquil water reflects the colors of the sunset. Smoke gently rises into the evening sky, creating a relaxed atmosphere.
Cabin in Moline
4.93 out of 5 average rating, 235 reviews

Riverfront Firepit, Kayaks, Huge Deck

Firepit ready for relaxing nights by the river. Kayaks included for warm days Wake up to sweeping Rock River views, sip coffee on the wrap-around deck, paddle out in the kayaks, and end your evening by the firepit as the sky glows at sunset. This eclectic riverfront bungalow blends vibrant décor with cozy comfort and seamless indoor-outdoor living. Perfect for girls’ weekends, fishing trips, romantic escapes, or peaceful fall getaways — just steps from the water and minutes to shops and dining

Guest favourite
A wooden deck overlooks Lake Odessa, with several blue chairs arranged for seating. The calm water reflects the cloudy sky, and green vegetation borders the shore, creating a peaceful lakeside environment.
Cabin in Wapello
4.88 out of 5 average rating, 25 reviews

Waterfront Cabin on Lake Odessa

Take it easy at this unique and tranquil getaway on Lake Odessa in Wapello, Iowa. Enjoy beautiful views and access to fishing, boating, and other natural attractions. This quaint cabin offers plenty of space to relax and enjoy the peace and quiet. Cabin offers two bedrooms with 3 beds and 1 sleeper sofa in the living room. Enjoy two full bathrooms, a half bath and a full kitchen. Cabin is within walking distance of water access, boat ramp, fishing areas and a cute local seasonal restaurant.

Top guest favourite
The log home features a front porch with several chairs, inviting relaxation while enjoying the surrounding nature. A wooden balcony extends from the upper level, complemented by decorative planters filled with flowers, enhancing the welcoming exterior.
Home in Letts
4.95 out of 5 average rating, 44 reviews

Shade Tree Farms in Letts, Iowa

Forget your worries in this spacious log home on 30 acres. Perfect for relaxing and renewing. Short drive to Muscatine with many historic sites, shops, unique restaurants. Near Grandview, Wapello, Letts, Columbus Junction with small town features and 35 miles from Iowa City. Mowed walking path around field. Exercise equipment. 2 car garage, 1 motorcycle garage. New pond. Privacy tucked into the field but just off the main highway. Sit and relax on massive front porch and watch the wildlife.

Top guest favourite
Home in Le Claire
4.96 out of 5 average rating, 435 reviews

Aire Leclaire 2-bedroom home

Your family will be close to everything when you stay at Aire Leclaire! Within walking distance from downtown and 2 blocks from American Pickers. This modern 2 bedroom, 1 bath home is a block away from the tugfest parade route. A barnyard turned farmhouse in the 1940’s, this home completely remodeled with the modern farm charm it has today. In town for a day or several, enjoy outdoor amenities, a lighted deck, outdoor couch, and table. Inside, a modern LED fireplace mixed with rustic beauty.

Top guest favourite
A bright eat-in kitchen features a wooden dining table surrounded by chairs, illuminated by pendant lights. A cozy bench sits near the entrance, while light streams through the window blinds. Wooden cabinetry and a granite countertop add functional elegance to the space.
Home in Muscatine
4.98 out of 5 average rating, 40 reviews

Helen's Henhouse

Welcome to the coziness of Helen's Henhouse, a lovingly restored 1890 home. Offering 4 cozy bedrooms, a delightful eat-in kitchen, an extra third-floor twin suite, and a generous living room featuring a dedicated work area, it's designed for retreats but perfect for any escape. Unleash your creativity in our well-equipped workspace, complete with 10 tables, design walls, a cutting station, and an ironing board. Your retreat, your way! A Retreat Haven for Every Stay. Unwind, Create, or Relax.

Top guest favourite
A screened porch features a round table surrounded by four chairs, all with green cushions. Natural light streams through the screens, showcasing views of a tranquil lake framed by colorful autumn foliage.
Guesthouse in Berwick
4.98 out of 5 average rating, 256 reviews

Private Guest Lake House On 37 Acres In Country

Private guest lake house, located next to main house, on private lake in the country. 2 bedroom, 1 full bath, full kitchen, washer and dryer and large attached screen porch. Private 37 acres of woods and prairie. Fishing and walking trails. Great window views of lake, woods, prairies and river valley. Please note, this guest house is located 1 mile down a county maintained gravel road. 25 minutes from Galesburg, IL, 20 minutes from Monmouth, IL and 35 minutes from Macomb, IL.

Top guest favourite
Cabin in Princeton
4.96 out of 5 average rating, 162 reviews

Private & Modern. Near river and wildlife refuge!

Experience the outdoors in comfort from this modern cabin, situated next to the 2200 acre Princeton Wildlife Management Area, and the nearby Mississippi River. It is ranked as the most “Wish Listed” Iowa listing of 2025 on Airbnb. Are you into hiking, biking, fishing, hunting, boating, or other water, winter, and summer sports? This cabin can support it all! Sit back and relax on the large deck while enjoying a coffee & the local wildlife, flora, & fauna of the Mississippi Valley Region.

Top guest favourite
Loft in Muscatine
5 out of 5 average rating, 16 reviews

Downtown;Walk to Shops, Restaurants, Entertainment

Located in the heart of Downtown - Enjoy great views of historic downtown Muscatine. - Steps away from restaurants, pubs, museums, and shopping. - Two blocks away from Mississippi Riverfront. - Enjoy a walk or bike ride along the trail system. - 2 bedrooms - one King and one Queen bed - WiFi, Smart TV and charging stations - Secure, safe location There are stairs to climb to reach the loft, and there is no elevator, but the spectacular views of Downtown are worth it when you get there!

Top guest favourite
Home in Muscatine
4.94 out of 5 average rating, 18 reviews

Pearl of Mulberry

Welcome to the Pearl of Mulberry! This cozy and elite property is perfect for business travel, families or small groups. Centrally located in Muscatine, you can quickly and easily get to our beautiful downtown area as well as the soccer fields and sports dome. Enjoy the convenience of amenities during your stay with a fully equipped kitchen, outdoor grill and full size washer and dryer. The Pearl of Mulberry will help you feel at home while you're traveling in picturesque Muscatine.

Top guest favourite
A vibrant garden of zinnias in shades of pink and orange flourishes in the foreground, leading to a red barn in the background. The barn features a gabled roof and is surrounded by greenery, creating a serene outdoor scene.
Barn in Solon
4.97 out of 5 average rating, 146 reviews

Beautiful, cozy barn in the quiet countryside

Come enjoy a relaxing get away on beautiful Sugar Bottom Road. A great place for the outdoor enthusiast, no matter the season. Ideal also for quiet relaxation and privacy. We are a small acreage just 15 minutes from Iowa City, 7 minutes from Solon, and 30 minutes from the Cedar Rapids airport. Our converted barn is at the back of the property, behind the house. There is a separate road leading back to the barn for super convenient parking. It’s rustic, cozy, warm and inviting.

Popular amenities for Muscatine vacation rentals

When is the best time to visit Muscatine?

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Avg. price$250 CAD$250 CAD$250 CAD$193 CAD$196 CAD$193 CAD$204 CAD$227 CAD$250 CAD$227 CAD$250 CAD$250 CAD
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Quick stats about vacation rentals in Muscatine

  • Total vacation rentals

    Explore 20 vacation rentals in Muscatine

  • Nightly prices starting at

    Muscatine vacation rentals start at $112 CAD per night before taxes and fees

  • Verified guest reviews

    Over 800 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space and kid-friendly amenities

  • Wifi availability

    10 of Muscatine vacation rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Muscatine rentals

  • 4.8 Average rating

    Muscatine stays are highly rated by guests—averaging 4.8 out of 5!

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