Vacation rentals in Muscatine

La Casita Guest House

La Casita is a family freindly, fully remodeled 3 bedroom/2 bath home. We are located within a 3 minute drive to historical downtown Muscatine. The kitchen is fully equiped and the home features a king bed, a queen bed and a twin bed for use (a pack-n-play is available if requested). Other features include full tub/shower combos in each bathroom, full size washer & dryer, smoke/carbon monoxide detectors, self check in with keyless entry, wifi, smart TV, and an enclosed private backyard area.

Historic West Hill Retreat

Beautiful historic 4 bedroom, 4 bath home within walking distance to shopping, bars/restaurants and all that downtown Muscatine has to offer. Enjoy sweeping views of the Mississippi River from several vantage points in and outside this home. The 3000 sf interior offers many places to gather and relax. Two of the bedrooms have on suite full baths. The other two bedrooms share a full bath. Additional amenities include, fully equipped kitchen, laundry, games, grill, outdoor entertainment area.

Shade Tree Farms in Letts, Iowa

Forget your worries in this spacious log home on 30 acres. Perfect for relaxing and renewing. Short drive to Muscatine with many historic sites, shops, unique restaurants. Near Grandview, Wapello, Letts, Columbus Junction with small town features and 35 miles from Iowa City. Mowed walking path around field. Exercise equipment. 2 car garage, 1 motorcycle garage. New pond. Privacy tucked into the field but just off the main highway. Sit and relax on massive front porch and watch the wildlife.

Helen's Henhouse

Welcome to the coziness of Helen's Henhouse, a lovingly restored 1890 home. Offering 4 cozy bedrooms, a delightful eat-in kitchen, an extra third-floor twin suite, and a generous living room featuring a dedicated work area, it's designed for retreats but perfect for any escape. Unleash your creativity in our well-equipped workspace, complete with 10 tables, design walls, a cutting station, and an ironing board. Your retreat, your way! A Retreat Haven for Every Stay. Unwind, Create, or Relax.

Private & Modern. Near river and wildlife refuge!

Experience the outdoors in comfort from this modern cabin, situated next to the 2200 acre Princeton Wildlife Management Area, and the nearby Mississippi River. It is ranked as the most “Wish Listed” Iowa listing of 2025 on Airbnb. Are you into hiking, biking, fishing, hunting, boating, or other water, winter, and summer sports? This cabin can support it all! Sit back and relax on the large deck while enjoying a coffee & the local wildlife, flora, & fauna of the Mississippi Valley Region.

Downtown;Walk to Shops, Restaurants, Entertainment

Located in the heart of Downtown - Enjoy great views of historic downtown Muscatine. - Steps away from restaurants, pubs, museums, and shopping. - Two blocks away from Mississippi Riverfront. - Enjoy a walk or bike ride along the trail system. - 2 bedrooms - one King and one Queen bed - WiFi, Smart TV and charging stations - Secure, safe location There are stairs to climb to reach the loft, and there is no elevator, but the spectacular views of Downtown are worth it when you get there!

Pearl of Mulberry

Welcome to the Pearl of Mulberry! This cozy and elite property is perfect for business travel, families or small groups. Centrally located in Muscatine, you can quickly and easily get to our beautiful downtown area as well as the soccer fields and sports dome. Enjoy the convenience of amenities during your stay with a fully equipped kitchen, outdoor grill and full size washer and dryer. The Pearl of Mulberry will help you feel at home while you're traveling in picturesque Muscatine.

Anchored Inn…Fun area for Hunting/boating/fishing

Hiking, Hunting, Boating & Fishing. Near Big river forest & Delabar State park. Close to Mississippi River & boat launches. Game room with air hockey, fooseball, dart board & board games. 3 bedrooms, including a master with bath. Laundry area. kitchen w/ coffee bar. Private deck with gas grill. Yard has a Fire pit. Keithsburg has a free disc/ frisbee golf corse. (bring your own disc’s) We have easy access parking for truck with a boat. Explore the area or just stay…Anchored Inn

Bridgeview home in Muscatine, Ia.

Relax with the whole family at this peaceful place to stay. A beautiful home that sits right on the edge of the Mississippi River along the train tracks in downtown Muscatine, right next to the bridge. Breathtaking views and house is right on the bike trail and is walking distance from the best restaurants and bars in town. Also has a big hot tub on the deck where you can relax with family and friends and enjoy the beautiful views overlooking the Mississippi River and bridge.😎

The Emerald Loft Apartment

Stay in a Historic District Downtown loft! River views. Nearby park, playground, bike trails, boat ramps & marina. Shopping, live music, & restaurants. Private entry with 1,000 sqr ft of space, open concept, full kitchen, TV, laundry, private bath, literally right in middle of everything. Check in at Creations by Oz "Jewelry, Wine, & Unique Finds". Enjoy a glass of wine upon check-in. Come hungry. Photo comments provide dining options within steps of the Emerald Room.

Captain's Cove Muscatine

A relaxing country getaway for all of life's moments! Rental includes a fully furnished house, kitchen, washer & dryer, WiFi, gas grill (1 propane tank), access to 4 private ponds (no fishing license required), 3 kayaks, adult/youth/infant lifejackets, concrete patio w/ firepit and outdoor patio furniture, and 5+ acres of private country land access (surrounded by 40 acres of private farmland). If you have any suggestions/ideas please let us know!

Rock River Escape

Enjoy your coffee, a nice bbq dinner, glass of wine, a good book, or just enjoy the sweeping views out of this cute bungalow. With 180 ft of unobstructed river views and river access, bring your fishing poles and get ready to relax and enjoy watching the water slowly drift by at this centrally located bungalow in a quiet residential neighborhood. Firepit with firewood provided. No parties allowed so please do not inquire about them.