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Vacation rentals in San Antonio

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in San Antonio

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost
Home in Santiago

Valle de Barbarena House

Excelente ubicación cerca del centro a tan solo 2 kilómetros un lugar tranquilo. Cerca del mall Casa de dos cuartos y dos camas Doble un sofá cama Espacio de Lavandería o depósito de almacenamiento Ve vecindario tranquilo Nice location near the city 2 km Away from the center of Santiago close to the mall It has 2 rooms each with a doble bed and a sofa bed in the living room Laundry room with nice space to bring in your bike or any thing that you will like to store inside the house.

4.83 out of 5 average rating, 12 reviews
Home in Santiago

House minutes from Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

4.84 out of 5 average rating, 25 reviews
Guest favourite
Home in Santiago

Yary's Little House

My accommodation is special because of its comfort and location. This accommodation is perfect for business trips, group trips, or relaxing with family. Strategically located at the entrance to the city of Santiago, it allows you to be close to everything: supermarkets, restaurants, shopping centres and more. 🏡 The space Enjoy a comfortable, modern and cozy atmosphere that will make your stay an unforgettable experience. Please do not smoke inside the property.

5.0 out of 5 average rating, 7 reviews
Top guest favourite
Home in Canto del Llano

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

4.92 out of 5 average rating, 63 reviews
Apartment in Santiago

San Juan Loft

San Juan Loft is a comfortable apartment located in the heart of Santiago de Veraguas, ideal for resting for one or more nights. It has a room with air conditioning, a private bathroom, an equipped kitchen, a living room, a dining room, Wi-Fi, and private parking. We also offer complimentary coffee, tea, sugar, and salt. We also offer self check-in. Perfect for travelers, work, or relaxation in one of the most important cities in inland Panama.

4.63 out of 5 average rating, 8 reviews
Guest favourite
Apartment in Santiago

Comfortable and safe apartment in downtown Santiago

Family apartment in downtown Santiago — comfortable, safe and fully equipped Enjoy a prime location in the heart of Santiago de Veraguas, a few steps from the cathedral, the municipal park and the main avenue. Everything you need is within walking distance: supermarkets, pharmacies, banks, shops, restaurants and transportation. Ideal for families, professionals, business travellers or people visiting the city for paperwork or events.

4.93 out of 5 average rating, 14 reviews
Apartment in Santiago

Cozy and beautiful apartment

Whether you are going for a walk to the city of Santiago, Veraguas, or work, in this beautiful apartment you will find comfort and tranquility so you can rest and disconnect from the routine. Its welcoming spaces, carefully decorated and equipped, will make you feel at home from the moment you arrive. Located in a quiet and safe area, it is the ideal place to relax after a day of work, sightseeing or shopping in the city.

5.0 out of 5 average rating, 4 reviews
A small dining area is featured with a round table and two folding chairs. Large windows offer views of lush greenery outside, while sheer white curtains partially filter natural light.
Apartment in Santiago

d'rosas apartments 3PB

Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from the city center, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

4.79 out of 5 average rating, 19 reviews
Superhost
Cottage in Parita District

Colonial House in Parita

Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.

4.8 out of 5 average rating, 50 reviews
Top guest favourite
A charming house is surrounded by lush greenery, featuring tall trees that frame the structure. The red exterior complements the vibrant garden, which includes a variety of colorful plants. A shaded porch invites relaxation, while the expansive lawn offers open space for family activities.
Home in París

Farmhouse

Relax with the whole family in this accommodation where tranquility is breathed. It is a farmhouse 100 meters from a Grade A milking parlor. Surrounded by nature with beautiful sunsets and centuries-old trees. It is fully equipped.

5.0 out of 5 average rating, 10 reviews
Superhost
A modern one-story home with a flat roof features large windows framed by wooden slats. A well-manicured lawn surrounds the entrance, while a concrete pathway leads to the front door. The exterior is painted in neutral tones, contributing to its contemporary design.
Home in Santiago

3BD, 2BTHS, furnished house

House with 3 bedrooms, 2 bathrooms, central, furnished, security booth, kitchen, automatic washing machine, A/A, Wi-Fi, cable TV, new construction in a nice residential area.

4.78 out of 5 average rating, 114 reviews
Guest favourite
Home in Santiago

Meters from Mall, Supermarkets, Hospital, etc.

Cozy, spacious, wifi, meters from Pricemart, pharmacies, restaurants, 40 minutes from Playa Torio, for families and groups of friends

5.0 out of 5 average rating, 10 reviews

Popular amenities for San Antonio vacation rentals