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Vacation rentals in San Antonio

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in San Antonio

Guests agree: these stays are highly rated for location, cleanliness, and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.73 out of 5 average rating, 56 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Home in Santiago
4.78 out of 5 average rating, 9 reviews

Valle de Barbarena House

Excelente ubicación cerca del centro a tan solo 2 kilómetros un lugar tranquilo. Cerca del mall Casa de dos cuartos y dos camas Doble un sofá cama Espacio de Lavandería o depósito de almacenamiento Nice location near the city 2 km Away from the center of Santiago close to the mall It has 2 rooms each with a doble bed and a sofa bed in the living room Laundry room with nice space to bring in your bike or any thing that you will like to store inside the house.

Home in Santiago
4.83 out of 5 average rating, 24 reviews

House minutes from Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Home in Santiago
5 out of 5 average rating, 3 reviews

Yary's Little House

My accommodation is special because of its comfort and location. This accommodation is perfect for business trips, group trips, or relaxing with family. Strategically located at the entrance to the city of Santiago, it allows you to be close to everything: supermarkets, restaurants, shopping centres and more. 🏡 The space Enjoy a comfortable, modern and cozy atmosphere that will make your stay an unforgettable experience. Please do not smoke inside the property.

Guest favourite
Home in Canto del Llano
4.91 out of 5 average rating, 43 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Superhost
Cabin in Toza

LaEstancia F13 House with Private and Equipped Pool

Welcome to La Estancia F13, a refuge designed for those looking to disconnect from the noise of the city and reconnect with the tranquility that only the interior can offer. Located in Toza de Natá, Coclé, this house has a private pool, is fully equipped and is only 5 minutes from the Toza River, one of the best-known natural attractions in the area. Here you will enjoy privacy, comfort and a truly peaceful environment to rest and recharge.

Guest favourite
Apartment in Santiago
4.92 out of 5 average rating, 12 reviews

Comfortable and safe apartment in downtown Santiago

Family apartment in downtown Santiago — comfortable, safe and fully equipped Enjoy a prime location in the heart of Santiago de Veraguas, a few steps from the cathedral, the municipal park and the main avenue. Everything you need is within walking distance: supermarkets, pharmacies, banks, shops, restaurants and transportation. Ideal for families, professionals, business travellers or people visiting the city for paperwork or events.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Apartment in Santiago
5 out of 5 average rating, 5 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

Top guest favourite
A charming house is surrounded by lush greenery, featuring tall trees that frame the structure. The red exterior complements the vibrant garden, which includes a variety of colorful plants. A shaded porch invites relaxation, while the expansive lawn offers open space for family activities.
Home in Paris
5 out of 5 average rating, 8 reviews

Farmhouse

Relax with the whole family in this accommodation where tranquility is breathed. It is a farmhouse 100 meters from a Grade A milking parlor. Surrounded by nature with beautiful sunsets and centuries-old trees. It is fully equipped.

Superhost
A modern one-story home with a flat roof features large windows framed by wooden slats. A well-manicured lawn surrounds the entrance, while a concrete pathway leads to the front door. The exterior is painted in neutral tones, contributing to its contemporary design.
Home in Santiago
4.78 out of 5 average rating, 114 reviews

3BD, 2BTHS, furnished house

House with 3 bedrooms, 2 bathrooms, central, furnished, security booth, kitchen, automatic washing machine, A/A, Wi-Fi, cable TV, new construction in a nice residential area.

Guest favourite
Home in Santiago
5 out of 5 average rating, 10 reviews

Meters from Mall, Supermarkets, Hospital, etc.

Cozy, spacious, wifi, meters from Pricemart, pharmacies, restaurants, 40 minutes from Playa Torio, for families and groups of friends

Superhost
A single-story house features an arched entry with decorative windows. The front porch is equipped with seating, surrounded by greenery. A paved driveway leads to the home, providing access for vehicles, while the roof offers ample shade.
Home in Santiago
4.73 out of 5 average rating, 37 reviews

Casa Nuevo San Juan

Easy access from the Panamericana. It is a central area with supermarket, pharmacy, restaurant, hospital.

Popular amenities for San Antonio vacation rentals