Boutique hotel vacation rentals in San Diego

Find and book unique boutique hotels on Airbnb

Top-rated boutique hotels in San Diego

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Guest favourite

A modern luxury tower with a sleek, angular design is depicted against a clear blue sky. The building features numerous glass windows, reflecting light and surroundings. Lush greenery flanks the base, enhancing the contemporary aesthetic of this high-rise structure.

Hotel room in Agua Caliente

4.85 out of 5 average rating, 92 reviews

Hotel Boutique Adamant Magic

If you are traveling for work, this is a perfect place to stay. LUXURY TOWER!!! Its a Loft, adorable SMALL place, that you would want to stay inside. either working or just enjoying your day . NO VISITS ALLOWED ADAMANT COMPLEJO DE LUJO!!! Perfecto para 2 adultos 2 niños. Pool is under maintenance, so it will not be available for the time being. Pago por adulto extra por noche $20.00 Dollars. PUEDES RENTAR A LARGO PLAZO TAMBIÉN Se requiere identificacion de los huesped para el acceso.

Guest favourite

A bright sleeping area features a spacious bed covered in crisp white linens, complemented by a plush accent pillow. Light wood furniture is arranged around the room, including a desk with a small television and a decorative plant, while natural light fills the space through a high ceiling.

Hotel room in South Oceanside

4.93 out of 5 average rating, 201 reviews

Cozy Designer King Room Steps 2 Restaurants&Shops

Featured in T&L, Conde Nast, and the LATimes! Located in hip, tranquil South Oceanside - blocks to the beach and great restaurants - and Carlsbad Village. Complimentary with your stay: 1 parking space Anytime use of natural cedar hot tub Beach cruisers Surf & boogie boards A spacious, private, and relaxing patio/picnic/firepit area for lounging Hi speed WiFi Outdoor shower for rinsing off after the beach Great bar/restaurant (Heritage BBQ) & grocer next door Local Guide/Map No service fees

Guest favourite

Hotel room in Barrio Logan

4.95 out of 5 average rating, 43 reviews

Hotel Narcissus - Room 6

Hotel Narcissus is a brand new 6-Room Boutique Hotel in the Logan Heights neighborhood of San Diego and features a Mexican Fusion Restaurant and Speakeasy Cocktail Bar called Alchemy. Logan Heights is one of the most beloved urban neighborhoods in San Diego due to its eclectic art scene and close proximity to Downtown. Hotel Narcissus is located at the base of the Coronado Bridge, less than 1-Mile Southeast of Petco Park. It is a 5-10 minute bike ride and a 20-25 minute walk to Downtown.

A well-lit room features a queen-sized bed with an aqua-colored throw and purple accent pillows. A flat-screen TV and a mini-fridge are positioned at the foot of the bed. A modern bathroom is visible through a partially opened door, with patterned tiles and natural light streaming through the window.

Hotel room in Ramona

4.19 out of 5 average rating, 27 reviews

Quite & Clean 2 Bed Room Country Suite in Ramona

Friendly Country Living Set along California State Route 78, this low-rise, wood-sided Inn is 7 miles from Lake Sutherland and Swartz Canyon County Park, and 12 miles from the San Diego Wild Animal Park. Homey, Air-Conditioned 2-Bedroom suites with country-style furnishings offer free WiFi and Digital Cable TV. Airy rooms feature mini-fridges and microwaves. Amenities include complimentary parking and an outdoor pool with a patio, lounge chairs and tables. Multiple restaurants nearby.

Guest favourite

A spacious room features a king bed adorned with soft, Italian linens and a plush throw. An accent wall in a calming blue contrasts with the bright white bedding. A doorway leads to the bathroom, visible in the background, completing the serene atmosphere.

Hotel room in Coronado

4.94 out of 5 average rating, 52 reviews

Hotel Marisol Coronado - King Room

With just fifteen rooms, this intimate setting is a perfect couples retreat. The hotel even has a private courtyard where you can relax and surrender to the coastal breeze. Guests rave about our ideal location, tucked away on a quiet street, but walking distance to everything Coronado - beach, shops, restaurants, and entertainment. Jumpstart your getaway with a glass of complimentary champagne upon arrival. Ask our staff about local dining spots. Take a sunset stroll along the beach.

Hotel room in Stockton

5 out of 5 average rating, 5 reviews

3BR Suite w/ Event Space & Resort Amenities Sleep8

What You Need to Know: - Exclusive rentals with top resort perks and amenities. - Event spaces with free upgrades for private gatherings. - Best value in San Diego—amazing rates per bed. - Early check-in from 1 PM (with approval); start your vacation early. - Prime location: 12 blocks from downtown, 3 miles from SAN Airport. - Good Life Resorts: 10 rentals, 34 bedrooms, 4 event venues. - Conference-grade WiFi and dedicated workspaces. - Complimentary welcome snacks and essentials.

Hotel room in Gaslamp Quarter

5 out of 5 average rating, 3 reviews

Prime SD Studio Suite | Queen Bed + Kitchen

Explore this centrally located San Diego suite designed for comfort and convenience. Perfect for up to 3 guests, it features a queen bed and twin air mattress with fresh linens. Enjoy free WiFi, an HD Smart TV, AC/heat, and a fully stocked kitchen for easy meals. Professionally cleaned to high standards, this non-smoking space ensures peace of mind. With Petco Park, Gaslamp Quarter, and Balboa Park nearby, you’ll be right at the center of it all in a safe and inviting setting.

Superhost

The illuminated Gaslamp Quarter entrance arch is captured at twilight. Streams of colorful light from passing vehicles create a dynamic scene. The surrounding buildings exhibit a mix of classic and contemporary architecture, contributing to the vibrant energy of this iconic San Diego neighborhood.

Hotel room in Downtown

4.94 out of 5 average rating, 17 reviews

San Diego Comicon Marriott Pulse-2 Bedroom Suite

Perfect for Comicon & Convention Center Events, the hotel is inspired by San Diego’s renowned Gaslamp Quarter, Enjoy the sleek, sophisticated setting to unwind from a day of exploration and recharge before venturing out to experience San Diego’s amazing nightlife. The suite includes 2 separate bedrooms and 2 separate living areas that are conjoined into one luxurious living space. With so much to see and do, you will need a place to come back to relax!

Guest favourite

Hotel room in Downtown

4.89 out of 5 average rating, 36 reviews

Stay in Charming APT | Modern + Prime location!

Explore all of San Diego’s beautiful downtown from this gorgeously restored historic hotel. Walk to everything … Gaslamp Quarter, Petco Park, Convention Center, world-class restaurants and lounges. … King Bed, with Queen Sofa Bed … Keyless entry … 42" Samsung Smart TV - Direct TV is included … Efficiency Kitchen / Kitchenette … Air conditioning … High ceilings, ceiling fan … Fast free WIFI … Professionally cleaned & managed

Superhost

A modern guest room features two spacious beds with light-colored bedding and decorative pillows. A plush toy is positioned on one bed. The room is illuminated by bedside lamps, with sleek wooden panels providing a warm contrast to the textured wall.

Hotel room in Gaslamp Quarter

Hotel Z, Z 2 Queen Suite Mobility Accessible w/Tub

You’ll get your much needed pampering experience when staying in the comfy accommodations at Hotel Z. Located in San Diego’s Gaslamp Quarter, we provide you with modern rooms full of signature amenities from our Stayppineapple Hotel brand that will ensure an exciting stay. We’ll even help you with getting around the city. An amenity fee with tax ($28.09 per day) will be charged upon arrival.

Hotel room in University Heights

New place to stay

2 Queen Beds

The listing is distributed and managed by RoomPicks Accommodations. THE UNIT This 350 sq ft 2 Queen Beds features: - 2 Queen beds; - Work desk; - Flat-screen TV; - Hairdryer; - Iron/ironing board; - Coffee maker, microwave and mini-fridge; - All linens, towels, and bathroom essentials are provided. You don’t need to bring a thing!

A spacious guest room features a king bed with a blue throw blanket and decorative cushions. Natural light enters through a large window dressed with sheer curtains. A wooden chair and bedside tables with lamps provide additional comfort and functionality in the modern, light-colored decor.

Hotel room in Shelter Island

4.51 out of 5 average rating, 185 reviews

Standard King, Ground Floor - Sea Harbor Hotel

Standard King, Ground Floor - is perfectly catered for a nightly retreat or long term stay by the shore. The newly renovated room features one king bed, modern nautical aesthetics and premium furnishings for a memorable experience on the San Diego Marina.