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Guesthouse vacation rentals in Santa Ana

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouses in Santa Ana

Guests agree: these guesthouses are highly rated for location, cleanliness, and more.

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Top guest favourite
A modern living area features a light-colored sofa and a wooden coffee table placed on a soft area rug. In the background, a dining table with chairs is visible, alongside a well-equipped kitchen with wooden cabinets. Natural light brightens the space through large windows.
Guesthouse in Santa Ana
4.97 out of 5 average rating, 167 reviews

Cozy 2-bedroom private guesthouse near South Coast

Step into this getaway house, away from all the hustle and bustle of daily life. You will find calmness and peace on your vacation. Indulge in a hot cup of coffee under the patio in a quiet environment or make your family a hot breakfast in the new kitchen before you head out to nearby attractions. Just bring your sun glasses and luggages. 5 minutes from South Coast Plaza. 25 Minutes from Disneyland Park. 20 minutes from all beautiful beaches, shopping centers and top restaurants of the region.

Guest favourite
A detached guest house is surrounded by a landscaped yard featuring various succulents and palm trees. A tall, textured wall provides privacy, while large windows reflect natural light. The outdoor area is paved and includes a small seating arrangement, creating a welcoming outdoor space.
Guesthouse in Eastside Costa Mesa
4.91 out of 5 average rating, 491 reviews

Eastside Casita

Located 1/2 mile from Newport Beach and walking distance to a variety of restaurants, cafes, bars, and stores it is great home base for exploring the Newport Beach and Costa Mesa area and is just 2 miles from the water! Guest house is detached from main house, has private entrance, parking, full kitchen and fenced off back yard space. The Patio includes a BBQ and patio table to enjoy So-Cal evenings or take in the sun while not out exploring. Accommodating for both adventure and work travel!

Top guest favourite
A comfortable living area features a light-colored sofa adorned with decorative pillows. A medium-sized television is positioned on a sleek wooden console. Large windows allow natural light to fill the space, offering views of surrounding greenery, while a wooden coffee table rests in front.
Guesthouse in Santa Ana
4.95 out of 5 average rating, 1,348 reviews

Quiet Peaceful Studio

Private studio apartment. Second-story unit, set back from the street, in a separate building behind the hosts' home. Located in a beautiful historic neighborhood, on a quiet street shaded by oak trees. Disneyland and the Anaheim Convention Center are only 10 minutes away. The Honda Center and Anaheim Stadium 5 minutes. The beaches are an easy 20 minute drive. Excellent restaurants and shopping are abundant. Close to Old Town Orange, Chapman University, and the Santa Artists Village.

Superhost
The spacious studio features a queen-size bed framed by minimalist decor. A comfortable sofa bed is positioned opposite a sleek coffee table. Large windows bring natural light into the room, while a stylish light fixture adds a modern touch to the space.
Guesthouse in Santa Ana
4.93 out of 5 average rating, 240 reviews

Lux Upper-Level Guest House 3mi to Disney Magic

Step into our inviting and snug haven! Our AirBnB is for anyone seeking a practical and budget-friendly lodging option. Situated in a secure and welcoming community, it offers seamless access to public transit and a plethora of eateries, coffee houses, and stores. Additionally, it's strategically placed near popular spots like Disney, Knotts Berry Farm, and Angel Stadium. Be it a work trip or a leisurely escape, our AirBnB promises a cozy abode away from home. We can't wait to host you!

Top guest favourite
A modern kitchen and living area are seen, featuring white cabinetry and stainless steel appliances. A wooden table with metal stools is positioned near the kitchen, while a blue couch with decorative cushions faces a light wood coffee table. Natural light enters through a window above the sink.
Guesthouse in Midway City
4.93 out of 5 average rating, 288 reviews

Oasis new unit near beaches, Little SG, Disney

This secluded unit is a newly built backyard cottage in the center of Orange County. 500 sqft. It has private entrance, equipped kitchen, 1BA, modernly furnished 1BR and living room. It is ideal for visiting Little Saigon (5 mins), SoCal beaches (15 mins), theme parks such as Disneyland (20 mins) coming from LAX (30 mins) or John Wayne Airport ( 14 mins). Minutes from Asian Garden Mall (PLT), Korean Garden Grove town, Bella Tera, Pacific City, Knott Berry Farms, Disney downtown etc.

Top guest favourite
A neatly organized kitchen features dark blue cabinets and light countertops, enhancing the functional space. Stainless steel appliances, including a gas range and microwave, are prominently displayed. A washing machine is positioned to one side, offering convenience for guests.
Guesthouse in Santa Ana
4.99 out of 5 average rating, 181 reviews

Near Disney, Private, Fast Wifi, Self Check-in

Private Guesthouse in the Heart of Orange County! Enjoy your own peaceful retreat in this newly built, detached guesthouse nestled in a quiet residential neighborhood. This bright and modern space offers complete privacy with its own entrance and a fully fenced patio—perfect for morning coffee or evening relaxation. Centrally located in Orange County, you’ll be just a short drive from top attractions, beaches, shopping, and dining, while still enjoying a calm, cozy place to unwind.

Top guest favourite
Guesthouse in Costa Mesa
4.95 out of 5 average rating, 699 reviews

Relax and revive at THE OASIS Poolside Bungalow

Relax, reset and revive in this chic and contemporary poolside bungalow with your own private pool and spa. The attention to detail in this mini-retreat will make you feel right at home. Lay out in sun or take a dip in the pool during the day and sit in the revitalizing spa at night. The bungalow is located within miles of many major attractions in OC such as Newport, Huntington and Laguna beaches, Disneyland, hiking trails and OC Fairgrounds. 2 guests maximum and NO PARTIES PLEASE

Guest favourite
An outdoor seating area is set beneath a covered deck, featuring a cozy sofa and two armchairs arranged around a coffee table. A patterned area rug brings warmth to the space, with panoramic views visible through the railing.
Guesthouse in Fullerton
4.96 out of 5 average rating, 540 reviews

Aviary with Amazing Views!

Perched on a hilltop with Amazing Views, Our place is walking distance from CSU of Fullerton and Fullerton Arboretum. We are located off the 57 fwy and a 20 min drive to Disneyland! It is a tiny cottage with modern amenities and although the cottage is detached from the main home, there is a cottage directly below, where you may hear noise if occupied. You may never see us, but available if needed. Enjoy a tranquil space with sounds of morning birds, outdoor fountains and a dog!

Top guest favourite
A spacious living area is showcased, featuring a white sofa adorned with yellow accent pillows. A warm brown lounge chair complements the neutral decor. A round mirror reflects natural light, while a small plant adds a touch of greenery to the welcoming atmosphere.
Guesthouse in Costa Mesa
4.96 out of 5 average rating, 252 reviews

Sunny Days - A Bright and Cheerful Guesthouse

Sunny Days is a beautiful and spacious 600 sq. ft. studio apartment with private entrance. You'll love the bright and airy space, complete with 10-foot ceilings! In the evenings, relax with a glass of wine in the cozy patio, grilling dinner on the BBQ, and hanging around the gas fire pit. We are centrally located to Newport Beach, John Wayne Airport, and Disneyland. Only a short walk to TeWinkle Park and the OC Fairgrounds. Easy free street parking in a lovely neighborhood.

Top guest favourite
A spacious bedroom features a king-size bed with decorative pillows and a throw blanket. Soft, neutral curtains frame large glass doors leading to an outdoor patio, and warm wall sconces illuminate the room. Nightstands are positioned on either side of the bed.
Guesthouse in Santa Ana
4.98 out of 5 average rating, 112 reviews

Cozy King-Bed+SofaBed 6Mi Disney 1.6 Mi Hospitals

Luxury Unit with King-Size Bed, Relax and unwind in our fully equipped unit. With everything you need for a comfortable and enjoyable stay, you're sure to have a memorable time. The unit features: Spacious bedroom with a king-size bed, 54" TV, and a Desk. The Living-room has a sofa bed, making it the perfect place to relax. The kitchen is fully equipped with everything you need. Whether you're on a business trip, vacation, or simply need a place to stay for a few nights.

Top guest favourite
The living area features a comfortable tan leather sofa paired with a woven storage ottoman. Natural light pours in through expansive sliding doors, leading to a private patio. A staircase with a black railing elegantly ascends beside the textured gray wall.
Guesthouse in Santa Ana
4.99 out of 5 average rating, 218 reviews

D'Loft By JC

D'Loft is newly built in July 2023. Your family will be close to everything when you stay at this centrally-located place. We are located 10-15 Min from Disneyland, the beach, shopping and much more! D'Loft features an open concept design, dressed in high end appliances and it's own private patio. Relax in a comfy Cal King Bed in addition to a queen size sofa bed + a twin sleeper, available at your disposal. Open the double sliders and make indoor outdoor space!

Top guest favourite
The bedroom features a spacious bed with plush bedding, flanked by stylish bedside lamps. A decorative rug adds warmth to the wooden floor. Accented by vibrant wall art, the room is illuminated by natural light filtering through a window above a mirrored closet.
Guesthouse in West Floral Park
4.98 out of 5 average rating, 454 reviews

Safe+Comfy! * 11 Min to Disneyland * Fruit Trees

Clean. Quiet. Comfortable. Safe! 11 minutes to Disneyland, this 1BR/1BA newly-renovated guesthouse in Santa Ana offers a relaxing atmosphere. Explore a beautiful yard w/Flowers+Organic Fruit Trees! Private & separate (doesn’t share walls w/main home). Safe and walkable neighborhood adorned w/gorgeous Gardens+Architecture. Centrally located within a 5-mile radius of theme parks, event venues, restaurants and shops. Relax, you've arrived.

Popular amenities for Santa Ana guesthouses

When is the best time to visit Santa Ana?

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Quick stats about guesthouse rentals in Santa Ana

  • Total vacation rentals

    Explore 80 vacation rentals in Santa Ana

  • Nightly prices starting at

    Santa Ana vacation rentals start at $69 CAD per night before taxes and fees

  • Verified guest reviews

    Over 7,650 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space and kid-friendly amenities

  • Rentals with dedicated workspaces

    40 properties have a dedicated workspace

  • Wifi availability

    80 of Santa Ana vacation rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santa Ana rentals

  • 4.8 Average rating

    Santa Ana stays are highly rated by guests—averaging 4.8 out of 5!

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