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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favourite
A modern single-story house is displayed with a large front porch and a carport. The exterior features a mix of light and dark materials, with a neatly landscaped yard and a white picket fence. Clear blue skies and scattered clouds complete the setting.
Home in Chame District
5 out of 5 average rating, 25 reviews

Casa de Veraneo

Lleva a toda la familia a este fantástico lugar con muchas zonas para divertirse. Cerca a todas las amenidades de Coronado, a pocos minutos de playas, laguna de San Carlos y a tan solo una hora y media de la ciudad. El PH cuenta con piscina del PH y una privada, en una zona tranquila y espaciosa. Encontraras 4 supermercados, farmacias, hospital privado (urgencias). Cerca a actividades campestres, playas, montañas, lago. Tiene en un gazebo con todas las comodidades. El lugar es seguro y completo.

Top guest favourite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 103 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Guest favourite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guesthouse in Panamá Oeste
4.81 out of 5 average rating, 101 reviews

Casa de Montaña en Panamá

Disfruta de la paz y la naturaleza en esta acogedora y equipada cabaña, perfecta para desconectar y relajarte. Rodeado de bosques y con vistas espectaculares, aquí podrás respirar aire puro y contemplar las estrellas. ✔️ Ideal para parejas, familias o aventureros. ✔️ Senderos, ríos y miradores cercanos. ✔️ Espacios cómodos y equipados para tu confort. - Capacidad de 4 personas. - Posibilidad de tener 1 cama doble y 2 individuales o 4 camas individuales. - Descuento a partir de dos noches.

Top guest favourite
An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.
Home in Costa Esmeralda
4.98 out of 5 average rating, 179 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with solar and battery backup systems.

Guest favourite
A balcony with a panoramic view of the coastline and turquoise waters is furnished with two cozy chairs and a small table. A long wooden bar table stands nearby, offering additional seating. The bright blue sky complements the scenic landscape.
Apartment in Nueva Gorgona
4.88 out of 5 average rating, 57 reviews

Apto piso 15 frente a la playa

Relájate con la familia en este alojamiento donde la tranquilidad se respira. El edificion cuenta con 4 piscinas, 1 jacuzzi, 1 sauna, Gimansio, cancha de volleyball, futsala, Pickelball o mini Tenis, ranchitos, un restaurante y area de BBQ esta ultima se renta por $25 adicionales. El Apto cuenta con 2 habitaciones, sala, area de desayunador, linea blanca completa con lava platos, centro de lavado, 3 aires acondicionados, secador de cabello, plancha, balcon. 1 cama queen y un camarate.

Superhost
An aerial view reveals a stretch of coastline featuring sandy beaches with a mix of dark volcanic sand and vibrant turquoise water. Lush greenery lines the shore, complemented by residential areas visible in the background, creating a serene and inviting landscape.
Tiny homes in San Carlos
4.8 out of 5 average rating, 123 reviews

Cozy beach cabin at Costa Esmeralda.

Cozy private community cabin on a triple space for up to three people located in Costa Esmeralda beach, over the Pacific ocean. Very quiet area with a 2,200 Square meter patio with trees and vegetation. Relax enjoying of the tropical sun, warm temperatures all year long and the ocean breeze. Only 8 minutes away by walk from the closest beach with warm waters and volcanic black sand. 10 minute drive to Coronado (Grocery Stores, restaurants, bakeries, movie theater, malls and more)...

Guest favourite
A stone paved area features four wooden chairs arranged around a central fire pit, illuminated by soft landscape lighting. In the background, a cabin structure can be seen, bordered by lush greenery and softly lit paths, creating an inviting outdoor space.
Cabin in Provincia de Panamá Oeste
4.88 out of 5 average rating, 250 reviews

Cabaña Buenavista by Casa Amaya

Casa Amaya es un complejo de cabañas ubicado a una hora de la ciudad capital, en Chicá de Chame, con temperaturas agradables entre 18 y 24 grados, donde podrás contactarte con la naturaleza y relajarte con tu pareja, amigos o familia. Otras cabañas: https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya Contamos con generador eléctrico en caso de apagón.

Top guest favourite
An elegant terrace features a private jacuzzi and is surrounded by lush greenery, with tranquil seating arrangements. The view includes distant mountains and a valley, enhanced by soft sunlight during sunset.
Loft in Chame District
5 out of 5 average rating, 15 reviews

Direction Chica 2 Grands Lofts, vue mer/Autodromo

🩷 DEUX Grands lofts indépendants. (2 personnes par loft) Endroit privé, exclusif, non partagé Chaque unité : WiFi - Air climatisé - Frigo 1 chambre 🛏️ (lit orthopédique) 1 salon 🛋️ 1 salle de bain 🚿 Stationnements Très sécuritaire Terrasse privée VIP juste pour VOUS Coin cuisine & Four à pizza au feu de bois 🍙 Profitez d'une vue incroyable sur la vallée, la mer, les îles de Punta Chame et le nouvel AUTODROMO 🏁 25 km de Coronado 28 km de Costa Verde 50 km de Panama

Top guest favourite
The exterior of the house features a charming design with a red-roofed upper level and a welcoming terrace. A small pool is visible in the foreground, surrounded by lush greenery and natural rock formations. Cloudy skies create a serene atmosphere, enhancing the tranquil setting.
Home in El Nancito
4.94 out of 5 average rating, 18 reviews

Mountain Retreat: Peaceful & Private Escape

Escape to tranquility in our beautiful rural retreat near Laguna de San Carlos, Panama. Nestled on a private hectare of lush land, this cozy two-bedroom, two-bath house boasts an open terrace with breathtaking views of the San Carlos mountains. Whether basking in summer sun or enveloped in clouds during the rainy season, you’ll find peace and beauty here. Just a 30-minute drive to Coronado and the stunning beaches of Panama Oeste, it’s the perfect sanctuary for your getaway.

Superhost
Cabin in Chame District
5 out of 5 average rating, 3 reviews

Puente entre Las Nubes

Puente entre Las Nubes cuenta con una habitación con cama queen y un baño exterior privado con vista a la montaña. Adicionalmente, cuenta con una amplia terraza bajo techo para colocar hasta 2 tiendas de acampar. Sala, comedor y cocina de concepto abierto brindando una experiencia de total inmersión en la naturaleza e impresionantes vistas a la montaña. Cuenta con area para BBQ, hamacas, columpios y redes suspendidas para descansar y relajarse.

Guest favourite
An inviting infinity pool is positioned on a spacious patio, overlooking a sweeping mountain view. Two lounge chairs are arranged on the deck, facing the water, while lush greenery and colorful blooms enhance the serene environment surrounding the pool area.
Cottage in Altos del Maria
4.94 out of 5 average rating, 165 reviews

Mountain Cottage with Heated Pool and Amazing View

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a heated infinity pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

Top guest favourite
Home in Nueva Gorgona
5 out of 5 average rating, 17 reviews

Spectacular Beachfront House

Beautiful house with private beach access right on the property. Relax on the hammocks and be surrounded by nature, with the best ocean view. Only 10 minutes drive from Coronado with all its amenities. There are two wonderful caretakers on the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz