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Guesthouse vacation rentals in Santo Domingo

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouses in Santo Domingo

Guests agree: these guesthouses are highly rated for location, cleanliness, and more.

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Top guest favourite
A single-story studio is presented with a warm orange exterior and two front windows, framed by black metal bars. A gated fence and small grassy area enhance the inviting entrance, while a paved driveway provides access to the space.
Guesthouse in El Millón
4.95 out of 5 average rating, 42 reviews

Private Cozy Apartment Studio

One bedroom studio, centrally located in the heart of El Millón, Santo Domingo, where comfort, convenience, and warm space offers the intimate feel of a family home, featuring: A private entrance for your complete privacy. Dedicated parking for your convenience and peace of mind. Whether you're visiting for leisure or business, our studio is thoughtfully designed to meet your needs. Remote workers will appreciate the high-speed internet, ensuring uninterrupted connectivity throughout your stay.

Guest favourite
A spacious room features a full bed with crisp white linens, flanked by two bedside lamps. Decorative artwork is displayed on the walls, while a wooden desk and a chair are positioned adjacent to the bed. The original hydraulic tile floor adds character to the space.
Guesthouse in Ciudad Universitaria
4.93 out of 5 average rating, 28 reviews

Centrally located and unique colonial-style studio

Unique space in a 1930s house, with rustic-industrial elements. Elegant room with original hydraulic floor. Large patio with perimeter fence and electric gate. Centrally located, less than 3 kilometers from the Colonial Zone, 2.5 kilometers from the Central Polygon. Hospital, Laundry, Pharmacy, Malecon 1-2 blocks away. 500-600 meters from 2 subway stations, close to museums and restaurants. Updated technology. Smart speaker. Wi-Fi. TV with YouTube, Netflix, Prime Video. Double bed (full size).

Guest favourite
Guesthouse in Santo Domingo
5 out of 5 average rating, 8 reviews

VillaMella Oasis 2bedroom2bathroom Patio Hot Water

Welcome to your Oasis in Villa Mella. Relax in comfort and luxury with a second-floor-level, 2 queen beds, 2 private baths, and a fold-out sofa. Enjoy A/C, hot water, fast WIFI, and 3 Roku TVs with Netflix. Secure smart lock entry and 24/7 on-site staff that will ensure peace of mind. Just a 5-minute walk from the Gregorio Gilbert Metro station. Bring the whole family to this great place with lots of room for fun. Need a driver? We've got you covered. Let us melt your stress away! Book now!

Guest favourite
A cozy bedroom is highlighted by a white bed with a bright yellow pillow. A small vase holds cheerful orange flowers, adding a touch of color to the space. Rich wooden cabinetry can be seen in the background, contributing to the room's inviting atmosphere.
Guesthouse in Santo Domingo Este
4.84 out of 5 average rating, 50 reviews

Cozy 2 BR with BBQ

This 2 bedroom apartment with BBQ private area is truly bright and cozy . It takes 25 minutes to arrive from the airport. The spacious master bedroom has a queen size bed and the very bright single room have two twins bed. You have discount with our car rental services with airport pick-up. The neighborhood is very safe, is private with access control and very clean, there are many restaurants nearby many bars, gyms, movie theaters, shopping malls . The neighbours are lovely and quiet.

Superhost
Guesthouse in Santo Domingo Este
4.67 out of 5 average rating, 30 reviews

Nest in the courtyard, 40 min from Bocachica beach 5 downtown

You will have the entire apartment just for you. Enjoy the tranquility that the area offers, an ideal place to rest and work, and a strategic point to travel to places of interest You are responsible for cleaning the accommodation during your stay. It is delivered clean. If you need it, you can request cleaning service at an additional charge. The patio is rarely shared. Usually, only you will enjoy the patio. The host is in charge of cleaning the patio area.

Top guest favourite
A bright living area features a decorative wall with a warm brick design, complemented by a wooden ceiling. A television is positioned on a simple black console, while a round dining table is adorned with a vase of elegant flowers, adding a touch of nature.
Guesthouse in El Millón
4.96 out of 5 average rating, 84 reviews

Cozy apartment for work / holidays.

Comfortable apartment, on second level, with private parking, ideal for holiday trips, congresses, jobs and others. Close to shopping centers, Recreational park, clinics, universities; 25 minutes from the colonial area. Located in downtown area of the city, in the urbanization El Millón del Distrito Nacional. Peaceful, residential place with access to the main roads of the city.

Top guest favourite
The exterior of the property features a modern one-story structure with a terracotta roof. Steps lead down to a clear pool, surrounded by well-manicured hedges and lush greenery. Soft lighting highlights the entrance, offering a welcoming presence during twilight.
Guesthouse in Santo Domingo
5 out of 5 average rating, 16 reviews

Guest House in the city/pool/USA Embassy

You no longer need to leave the city to feel in the mountains, this is an independent 1 bed 1 bath Guest House in a closed residence with a 10-meter pool shared with the Hosts. With a Coway potable water filter. Supermarkets, Cinema, Shops, and Hair Salon nearby. A few minutes from the center of Santo Domingo and 1.8 km from the American Embassy.

Top guest favourite
Guesthouse in Las Caobas
4.91 out of 5 average rating, 22 reviews

Your little corner of peace in SDO

Kick back and relax in this calm, stylish space. “Tu rinconcito de Paz” is an oasis in the middle of the city rush, take some fresh air in our outdoor Gazebo area, enjoy the privacy and security of our small but cozy house. Commercial centers as Carrefour and numerous restaurants are located at 8 minutes away from our spot.

Guest favourite
The outdoor area features a spacious parking lot with several vehicles, surrounded by greenery and landscaped pathways. A basketball court is visible in the background, alongside a multi-level patio area with seating for outdoor gatherings. Palm trees provide shade in this tranquil setting.
Guesthouse in Santo Domingo
4.93 out of 5 average rating, 15 reviews

U.S. Embassy Suites

Have fun with the whole family at this stylish place while taking it easy at a unique and tranquil getaway. Perfect while on the go or for appointments at the U.S. embassy. Guesthouse comes included with access to an olympic style pool, outdoor patio and barbecue grill. Great for evening get togethers and celebrations.

A wide view of a vibrant street lined with historic buildings features a prominent clock tower in the background. Arched doorways and balconies are visible, while pedestrians and birds inhabit the bustling area, showcasing a lively atmosphere.
Guesthouse in San Carlos
4.65 out of 5 average rating, 152 reviews

Cozy Separate Room in Santo Domingo Colonial

Aparta - Estudio- Privado con Patio compartido. Cómodo - espacioso, próximo a la zona colonial, palacio presidencial, parque independencia, Malecon. Primera ciudad del continente americano. Zona más turística de Santo Domingo. Most tourist area of ​​santo domingo! Great for sightseeing

Guest favourite
A lush backyard features a swimming pool surrounded by greenery and decorative elements. A barbecue grill is positioned on a stone patio, while comfortable seating arrangements invite relaxation. Colorful plants and well-maintained flower beds enhance the serene outdoor setting.
Guesthouse in Residencial Alameda
4.87 out of 5 average rating, 87 reviews

Private oasis with pool in quiet residential area

Private pool just for you. Independent attached house with large garden and terrace ideal for enjoying with the family. Located in a quiet and safe residential area, close to everything. Air-conditioned and comfortable spaces. Perfect for getaways, weekends and city breaks.

Guest favourite
Guesthouse in Los Frailes
4.83 out of 5 average rating, 6 reviews

Mamuchi House, San Isidro Free Trade Zone, Air Base

2 bedroom apartment with A/C, private bathroom, 3rd floor. Ideal for you if you are looking for a comfortable space near the Free Trade Zone of San Isidro and Air Base, rest in a family atmosphere. Base rate valid for 2 people, one room.

Popular amenities for Santo Domingo guesthouses

When is the best time to visit Santo Domingo?

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Quick stats about guesthouse rentals in Santo Domingo

  • Total vacation rentals

    Explore 70 vacation rentals in Santo Domingo

  • Nightly prices starting at

    Santo Domingo vacation rentals start at $14 CAD per night before taxes and fees

  • Verified guest reviews

    Over 1,270 verified reviews to help you choose

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    50 properties have a dedicated workspace

  • Wifi availability

    70 of Santo Domingo vacation rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santo Domingo rentals

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