Vacation rentals in Cape Girardeau

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Cape Girardeau

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favourite

Apartment in Cape Girardeau

4.97 out of 5 average rating, 345 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Jun. 7 – 14

$148 CAD per night
Guest favourite

Home in Jackson

4.92 out of 5 average rating, 263 reviews

The Rusty Owl-A Charming Victorian Dwelling

The Rusty Owl is a peaceful place with easy access to I-55. House has high speed (300 up and down) wifi. Jackson: Check out Flickerwood Arena, (9 minutes away... for ATV and barrel racing; horse shows and rodeos) Jackson History Center: Free. Open daily. Cape Girardeau: Live music and relaxation at The Library and 21 Taps. Hunter Valley Winery open weekends. 1 private lower level queen bedroom/ two private (1 queen, 1 twin) rooms and room with a antique full bed and a twin bed upstairs.

Nov. 18 – 25

$155 CAD per night
Guest favourite

Guest suite in Cape Girardeau

4.96 out of 5 average rating, 108 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

May 7 – 14

$122 CAD per night

Popular amenities for Cape Girardeau vacation rentals

Stay near Cape Girardeau's top sights

Capaha Park4 locals recommend
Dogwood Social House3 locals recommend
Port Cape13 locals recommend

Other great vacation rentals in Cape Girardeau

Guest favourite

Apartment in Cape Girardeau

4.97 out of 5 average rating, 59 reviews

Private Downtown Apartment

Oct. 16 – 23

$184 CAD per night
Guest favourite

Treehouse in Cape Girardeau

4.98 out of 5 average rating, 53 reviews

Twisted Sassafras Treehouse

Mar. 5 – 12

$404 CAD per night
Guest favourite

Guest suite in Cape Girardeau

4.86 out of 5 average rating, 57 reviews

[*Charming Cozy Suite*]

May 30 – Jun. 6

$95 CAD per night
Guest favourite

Guest suite in Cape Girardeau

5.0 out of 5 average rating, 92 reviews

Cape Comfy! Close to SEMO & Capaha! CLEAN! 5 Star!

Sep. 4 – 11

$125 CAD per night
Superhost

Home in Cape Girardeau

4.82 out of 5 average rating, 66 reviews

Herman’s Cozy Corner

Nov. 16 – 23

$140 CAD per night
Guest favourite

Barn in Cape Girardeau

4.95 out of 5 average rating, 100 reviews

Under the Stars - Farmhouse

Nov. 10 – 17

$323 CAD per night
Guest favourite

Guesthouse in Cape Girardeau

4.95 out of 5 average rating, 56 reviews

Cozy 1-BR guest house w/free parking on premises

Feb. 15 – 22

$115 CAD per night
Guest favourite

Cottage in Cape Girardeau

4.91 out of 5 average rating, 75 reviews

Country cottage with view of winding creek

Apr. 26 – May 1

$220 CAD per night
Guest favourite

Apartment in Cape Girardeau

4.83 out of 5 average rating, 23 reviews

Gail's Corner Window- River View

Apr. 19 – 26

$197 CAD per night
Guest favourite

Home in Cape Girardeau

4.94 out of 5 average rating, 65 reviews

House Of Clubs- 2 Bed 1.5 Bath

May 28 – Jun. 4

$217 CAD per night
Guest favourite

Home in Cape Girardeau

4.95 out of 5 average rating, 38 reviews

Cozy Cottage

Aug. 21 – 28

$233 CAD per night
Superhost

Home in Cape Girardeau

4.78 out of 5 average rating, 27 reviews

3 Bed Bungalow w/ Deck and Fenced-In Back Yard

Oct. 14 – 21

$170 CAD per night

Quick stats about vacation rentals in Cape Girardeau

Total rentals

140 properties

Rentals with dedicated workspaces

90 properties have a dedicated workspace

Pet-friendly rentals

40 properties allow pets

Family-friendly rentals

60 properties are a good fit for families

Total number of reviews

8K reviews

Nightly prices starting at

$27 CAD before taxes and fees

Destinations to explore