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Vacation rentals in Cape Girardeau

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Top-rated vacation rentals in Cape Girardeau

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest suite in Cape Girardeau
Cape Comfy! 5 Star Reviews! Totally Private! CLEAN
The Cape Comfy is in a safe, quiet neighborhood perfectly located next to SEMO, SE Hospital, Capaha Park & the historic district - all less than a 7 minute walk! We have turned the bottom floor of our house into a magnificently cute apartment with complete privacy - private entrance, bathroom, & even your own laundry room! There is also a dining room table, frig, microwave, living room w/TV, pool table, & free WIFI. No shared space & CLEAN! We are Superhosts with over 255 reviews! ALL 5 STAR!
SUPERHOST
Rental unit in Cape Girardeau
Unique Design | Walk Downtown/River | .5 mile SEMO
At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy the Luxury of being near Downtown with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.
SUPERHOST
Home in Cape Girardeau
❤ of Cape Girardeau *5min→Hospitals & SEMO
Perfect for nurse/professional or weekend traveler looking for a house to themselves. This 2 bd. 1 ba. home sleeps four, it offers WIFI and loads of privacy with a mid-century feel! Cook meals in the fully stocked kitchen. Convenient washer and dryer. Wake up to the sights and sounds of nature in the large front yard and private backyard. Hit the coffee/tea bar then relax in the sunroom, porch, or back patio. Private drive with carport. Close to both hospitals, univ., and interstate 55.
SUPERHOST

Stay near Cape Girardeau's top sights

Photo of Katy O'Ferrell's Publick House
Katy O'Ferrell's Publick House9 locals recommend
Photo of Capaha Park
Capaha Park4 locals recommend
Photo of Dogwood Social House
Dogwood Social House3 locals recommend
Photo of Port Cape
Port Cape13 locals recommend
Photo of Pilot House Restaurant & Catering
Pilot House Restaurant & Catering3 locals recommend
Photo of Mary Jane bourbon + smokehouse
Mary Jane bourbon + smokehouse7 locals recommend

Other great vacation rentals in Cape Girardeau

Rental unit in Cape Girardeau
Historic Downtown Getaway Sleeps 1 to 4 guests
SUPERHOST
Guesthouse in Cape Girardeau
Downtown Guesthouse- Romantic Getaway
SUPERHOST
Guest suite in Cape Girardeau
MAINSTAY CAPE [downtown]
SUPERHOST
Private room in Cape Girardeau
"White Picket Fence" 'Lower Area Get Away'
SUPERHOST
Home in Cape Girardeau
Herman’s Cozy Corner
Loft in Cape Girardeau
Loft #4 Downtown Cape Girardeau , Music & Food
SUPERHOST
Rental unit in Cape Girardeau
Beautiful Historic Boulevard District Apartment
SUPERHOST
Rental unit in Cape Girardeau
Updated 3 bedroom unit with balcony!
SUPERHOST
Private room in Cape Girardeau
Private room by the university and hospital
SUPERHOST
Rental unit in Cape Girardeau
Brand new 2 bedroom unit right in downtown Cape.
SUPERHOST
Home in Cape Girardeau
Escape to DOWNTOWN CAPE! Entire House!
SUPERHOST
Tiny homes in Cape Girardeau
Little Blue Cottage