Vacation rentals in Cape Girardeau

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Top-rated vacation rentals in Cape Girardeau

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favourite
Apartment in Cape Girardeau
Beautiful Historic Boulevard District Apartment
This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.
Jan. 21 – 28
$144 CAD per night
4.97 out of 5 average rating, 344 reviews
Guest favourite
Home in Jackson
The Rusty Owl-A Charming Victorian Dwelling
The Rusty Owl is a peaceful place with easy access to I-55. House has high speed (300 up and down) wifi. Jackson: Check out Flickerwood Arena, (9 minutes away... for ATV and barrel racing; horse shows and rodeos) Jackson History Center: Free. Open daily. Cape Girardeau: Live music and relaxation at The Library and 21 Taps. Hunter Valley Winery open weekends. 1 private lower level queen bedroom/ two private (1 queen, 1 twin) rooms and room with a antique full bed and a twin bed upstairs.
Aug. 29 – Sep. 5
$168 CAD per night
4.92 out of 5 average rating, 264 reviews
Guest favourite
Treehouse in Greenville
NEW treehouse B&B for 2 "The Roost” with hot tub
Cozy new 2022 custom built rustic but not primitive cabin 2 hours south of St Louis MO. Yes it has indoor plumbing and running water. Accommodates two adults only, has a fully equipped kitchen and breakfast items are provided for you to cook. Surrounded by thousands of acres of national forest. Observe wildlife sightings from the deck while soaking in the hot tub, sleep comfortably in a queen size pillowtop Serta bed on a Motion Air base, and relax as you enjoy the ambience of the fireplace.
Feb. 7 – 14
$269 CAD per night
5.0 out of 5 average rating, 134 reviews

Popular amenities for Cape Girardeau vacation rentals

Stay near Cape Girardeau's top sights

Capaha Park4 locals recommend
Dogwood Social House3 locals recommend
Port Cape13 locals recommend

Other great vacation rentals in Cape Girardeau

Guest favourite
Apartment in Cape Girardeau
Private Downtown Apartment
Nov. 15 – 22
$183 CAD per night
4.97 out of 5 average rating, 59 reviews
Guest favourite
Guesthouse in Cape Girardeau
Cozy 1-BR guest house w/free parking on premises
Feb. 5 – 12
$115 CAD per night
4.94 out of 5 average rating, 54 reviews
Guest favourite
Barn in Cape Girardeau
Under the Stars - Farmhouse
Sep. 17 – 24
$317 CAD per night
4.95 out of 5 average rating, 97 reviews
Guest favourite
Cottage in Cape Girardeau
Country cottage with view of winding creek
May 24 – 31
$195 CAD per night
4.91 out of 5 average rating, 74 reviews
Guest favourite
Home in Cape Girardeau
Ace Of Hearts- 1 Bed 1 Bath
Jul. 9 – 16
$179 CAD per night
4.84 out of 5 average rating, 19 reviews
Guest favourite
Guest suite in Cape Girardeau
Cape Comfy! Close to SEMO & Capaha! CLEAN! 5 Star!
Jun. 27 – Jul. 4
$112 CAD per night
5.0 out of 5 average rating, 91 reviews
Guest favourite
Apartment in Cape Girardeau
Gail's Corner Window- River View
Jun. 2 – 9
$226 CAD per night
4.82 out of 5 average rating, 22 reviews
Guest favourite
Apartment in Cape Girardeau
Historical Kage House
Jul. 19 – 26
$231 CAD per night
4.97 out of 5 average rating, 73 reviews
Guest favourite
Tiny homes in Jackson
The Cottage, Rusted Route Farms
Apr. 1 – 6
$235 CAD per night
5.0 out of 5 average rating, 13 reviews
Guest favourite
Home in Cape Girardeau
Deer Run Creek: 5 Bed Home in Great Neighborhood
Oct. 14 – 21
$307 CAD per night
4.8 out of 5 average rating, 86 reviews
Guest favourite
Home in Cape Girardeau
Cozy Cottage
Aug. 4 – 11
$231 CAD per night
4.95 out of 5 average rating, 38 reviews
Guest favourite
Apartment in Cape Girardeau
Visit the "Gone Girl" neighborhood
Dec. 29 – Jan. 5
$122 CAD per night
4.89 out of 5 average rating, 88 reviews

Quick stats about vacation rentals in Cape Girardeau

Total rentals

140 properties

Rentals with dedicated workspaces

90 properties have a dedicated workspace

Pet-friendly rentals

40 properties allow pets

Family-friendly rentals

60 properties are a good fit for families

Total number of reviews

8K reviews

Nightly prices starting at

$27 CAD before taxes and fees

Destinations to explore