Boutique hotel vacation rentals in Missouri

Find and book unique boutique hotels on Airbnb

Top-rated boutique hotels in Missouri

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Guest favourite

Boutique hotel in Washington

4.98 out of 5 average rating, 102 reviews

River Sirens Hotel Deluxe Suite

11 Room Boutique Hotel in beautiful Downtown Washington. Each room has: Private Entrance Guest Access - Key Pad, Free Parking, King Size bed, TV, Wifi, Hair Dryer, Individual A/C & Heat. Guests can enjoy a shower room featuring a changing area with separate vanity and water closet spaces. Every room as a very large balcony with river views. Each room is also equipped with a full kitchen featuring large refrigerators w/ ice dispensers, induction stove top, microwave, toaster, and coffee station.

Jan. 6 – 13

$257 CAD per night

Guest favourite

Boutique hotel in Springfield

4.97 out of 5 average rating, 122 reviews

King of the Road at Rockwood Court on Route 66

King of the Road, named after Roger Miller’s 1965 #1 hit song, is a throwback to the 1960’s at Rockwood. Decorated in kitsch and camp; this room is a deja vu of those days of velvet paintings, shag carpet, and the age of Aquarius. Release your inner hippie and enjoy a stay in King of the Road! Newly renovated in 2019, you’ll enjoy clean and comfortable room amenities while experiencing authentic motor court lodging. Need more space? We can package multiple rooms to accommodate your group!

Nov. 21 – 28

$119 CAD per night

Guest favourite

Boutique hotel in Osceola

4.92 out of 5 average rating, 75 reviews

Historic Commercial Hotel(1868),Sally Rand Suite

The Historic Commercial Hotel (Est.1868) on the Downtown square in beautiful Osceola,Missouri. Old world feel with modernized accommodations. The Historic Commercial Hotel has numerous themed rooms which are designed and named after past historical guests. This specific room is "The Sally Rand Suite". Named after past historical guest Sally Rand ( 1904 – 1979) who was an American burlesque dancer and Silver Screen star, most noted for her ostrich feather fan dance and balloon bubble dance.

Nov. 1 – 8

$116 CAD per night

Guest favourite

Boutique hotel in Eldon

5.0 out of 5 average rating, 26 reviews

#10 A 1930’s motor court, Historic Randles Court

Family owned and operated! Built in the early 1930s, our recently restored rooms will take you back to simple times. The days of bus & railway rest stops, road-trips in the family car, and the quintessential motor court -the era of the Great American Motel. Our town is alive with new and old businesses alike - places to eat, shop, and play for everyone in the family! We’re centrally located in downtown Eldon-just 15 minutes from the Lake of the Ozarks and 30 minutes from Jefferson City.

Nov. 11 – 18

$151 CAD per night

Guest favourite

Boutique hotel in Springfield

4.98 out of 5 average rating, 41 reviews

Culture Boutique Hotel: Casablanca Suite

We're located on Historic C-Street, home to artisan shops, Askinosie, a farmer’s market, yoga studios, wedding venues + more. Downstairs from our hotel is our very own coffee shop! Our loft-like suites feature furniture made from reclaimed materials from our building, a converted mattress factory. Each suite is inspired by a city in Eurasia. The rooms boast high ceilings, a 39in tv, a refrigerator, microwave and a V60, Electric Kettle, + complimentary coffee from Eurasia Coffee & Tea.

Apr. 13 – 20

$197 CAD per night

Guest favourite

Boutique hotel in Hannibal

4.95 out of 5 average rating, 100 reviews

The Woodsman Suite

A third floor suite, facing the river with the train tracks only a couple blocks away. It took 2 months to do the ceiling. Carefully polished and placed the old lath in a specific design, the ceiling is a work of art. Eighty percent of the material used in this room is from re purposed lumber, either from this building or from a childhood barn built in the late 1800's. It will take you a while to notice every detail down to the toilet paper holder which is from an old barn post.

Jan. 10 – 17

$190 CAD per night

Guest favourite

Boutique hotel in Pacific

4.9 out of 5 average rating, 39 reviews

Pilot four. room for two with pool

Bookings are allowed 6 months in advance. Private queen room in a new boutique hotel offers a cozy queen bed, half bath in suite. There are shower rooms located on the 2nd floor near this room. There is a comfy common area outside the room, as well as additional shared spaces on the main floor. There is a large community kitchen for use and plenty of dining and activity spaces. Please only 1 med to lg dog for this space. if traveling with smaller pets please inquire.

Aug. 27 – Sep. 3

$185 CAD per night

Guest favourite

Hotel room in Kansas City

4.94 out of 5 average rating, 17 reviews

Westside at Oak Street Mansion

Interested in staying somewhere unique, high class, and yet central to all that KC has to offer? Look no further! You are at the epicenter of culture: split between the Nelson Atkins & Kemper Art Museums, not to mention the Kansas City Art Institute. The Mansion is minutes away from the Country Club Plaza, Westport and Brookside. Enjoy the beautiful grounds and gazebo while sipping a mug of coffee, or lounge in the sunroom on the first floor of the Main House.

Jan. 15 – 22

$241 CAD per night

Guest favourite

Boutique hotel in Hermann

4.97 out of 5 average rating, 121 reviews

The Artists Suites, Claude Monet Suite

One of four rooms available at the Artist Suites, The Monet Room is carefully crafted to represent the unmatched talent of Claude Monet. You will not be disappointed with your stay at this creative property, which also hosts an art gallery and studio next door. All 4 rooms are located on the second floor, sharing a hallway in our beautiful brick building, constructed in the late 1800’s.

Aug. 21 – 28

$200 CAD per night

Guest favourite

Boutique hotel in Saint Louis

4.89 out of 5 average rating, 829 reviews

King Redwood Bedroom at BnB in CWE!

This is the largest of the rooms we have at our CWE BnB - an historic house in St. Louis' premier neighborhood. It has one King sized bed, a pullout sleeper sofa, two back-to-back 45" 4K Smart TVs with Rokus, and bathroom and kitchen space shared with guests of other rooms on this floor. Within a short walk of the basilica and many bars and restaurants in the CWE!

Sep. 16 – 23

$137 CAD per night

Superhost

Boutique hotel in Washington

4.86 out of 5 average rating, 132 reviews

430 West Front: Balcony Riverfront View

This room is located on the second floor over our quaint wine bar with a private balcony overlooking the Missouri River. Enjoy a cup of coffee or glass of wine from our wine bar on your private balcony. Just steps from our Historic downtown riverfront community with plenty of bars, restaurants, and charming shops to explore.

Feb. 12 – 19

$205 CAD per night

Superhost

Boutique hotel in Louisiana

5.0 out of 5 average rating, 4 reviews

The Eagles Nest Inn

The Eagles Nest Inn is a family-run Inn tucked away in historic downtown Louisiana, Missouri. Our lovingly restored historic building features comfortable and inviting guest rooms, each with its own unique character. You'll experience our quaint town like a local, thanks to our helpful tips and recommendations.

Dec. 14 – 21

$192 CAD per night