
Family-friendly vacation rentals in Picayune
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Top-rated family-friendly rentals in Picayune
Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for Picayune family-friendly rentals
Family-friendly home rentals with a hot tub

Legacy Tower 2- 1101
Very smooth transaction. The unit was clean and functional, Since we checked in late we had some challenges finding our parking permits, but the host facilitated and delivered the passes to our unit the following day. We'll recommend the location. Great view, not within a walking distance, but shops and eateries were a short drive away. Did enjoyed our stay. Thank you!

Legacy Tower 2- 809
The pictures don’t do justice to this beautiful condo! Location is superb, the condo itself is spotlessly clean and our house so very responsive. We plan to be back next year

Coastal, Casual, Comfortable Living
This beautiful condo would get a 10 star review if we could. Conveniently located, very quiet and you don’t hear any road noise, which is appreciated during the car shows. Brenda is super nice and keeps her place more than clean, it’s amazing! She responds quickly although there shouldn’t be any open questions since she has everything laid out perfectly in a folder. We had a fantastic week and are hoping to come back soon.
Family- and pet-friendly home rentals

Old Town Beach Cottage Newly Renovated
Perfect peaceful getaway. Wonderful location. Everything you could possibly need is provided. The golf cart was a fun way to explore the quaint neighborhoods and beach road. Highly recommend.

Secluded Beach House with Amazing Views 5 Bedrooms
This is the third winter that we have stayed at Amy's beach house. It is by far our favorite rental property and we have stayed at several rentals over the years. The house is awesome and has everything you need for a very enjoyable and relaxing vacation. The location, 600 feet from the beach, is incredible and the beach is dog friendly which is very important for us. The area is very quiet with very little traffic even during peak hours. There are countless restaurants in the area including Waveland, Bay St. Louis, Pass Christian, Gulfport, Biloxi, Ocean Springs etc. All are very drivable. Amy is an excellent and responsive host. Mr. Billy, who provides handyman services for Amy, is wonderful and rapidly dealt with any household issues which were very minor in nature and easily resolved. We certainly very much appreciate Mr. Billy. We are planning on renting the house again for next winter. Thank you Amy for your excellent support throughout our stay.

"Chickie's Roost" family-friendly barn apartment
We had an amazing stay! The accommodations were clean, comfortable and thoughtful. Lavonne was super kind and accommodating, and we truly appreciate her hospitality. Her animals were so sweet and always ready for pets. The location was quiet, beautiful, and relaxing. The only downside is that we couldn’t stay longer!

Secret Garden
This house was perfect for our family. Lots of space inside and outside. They had a stocked kitchen with everything we needed.

Unique lake house minutes from Coast attractions
If you are looking for a relaxing, quiet, and peaceful place to rest, this is it. Far from the hustle and bustle with the amenities of home. The house sits on a hill overlooking part of the lake. There is a small local grocery and deli nearby. You will travel 20-30 minutes for hiking trails, full grocery stores, and a larger selection of places to eat. We enjoyed our stay very much.

Biloxi Beach View Getaway
This was such a wonderful home and place to stay! We had both of our mothers travel in with us for the Christmas holiday and we couldn’t have asked for a better stay. The location is perfect - so close to the beach, shopping and the casinos. The house was so clean and had everything we needed and a great backyard for our dogs. Would definitely recommend and would look to stay here again the next time we’re in Biloxi.

3bed/3bath(17)Townhouse Gulfport/Biloxi near Beach
We had a great family stay. Easy to access, clean, kids had a great time. Easily accommodated our family of seven. Quiet area. Train runs thru and was noisy during night but even that kids thought was fun. Sadly the pool was not available but the beach was close and we had a good time there. Really enjoyed. Would definitely go back. Thank you.

Sycamore Street Cottage
Very nice little place with lots of charm and plenty of room, 3 outdoor sitting areas, great TV and wifi, in a super location, so if you can walk a few miles you can get anywhere in the historic district on foot. We enjoyed our stay very much.
Family-friendly home rentals with a pool

Biloxi Cozy Retreat
This was a beautiful space, very updated, pool right outside your back door and the neighbors were very hospitable. This was the perfect short term living arrangement for my training. Bed comfy, couch comfy and the kitchen with bar seating was super inviting. Jim was very responsive with the only immediate issue. Location was perfect for everything! Only con was the extensive cleaning check out list required for check out that was not received until after booking.

Beach Getaway
As two girls traveling alone, Stephanie’s place was exactly what we were looking for. Clean, private, safe, and we loved that we could walk to the beach along with other attractions! Thank you for an awesome stay and being attentive to our needs!

Biloxi Blues! MS Gulf Coast
First floor condo. Right by the pool. As described. Very clean! We had a great time! Thank you!

Ground Floor Beach & Casino Getaway!
Very clean and cozy place. Was gated and very safe. I would recommend this place to anyone, the owners were very communicative and helpful. You won’t find a cleaner nicer place for the money !

South Beach Condo
We had a wonderful stay! We cannot wait to stay again! Staff were very friendly and made us feel at home!

Seaside Gem
It’s my 22nd birthday today and I loved it everything was neat and clean the beds were comfortable the patio was clean and privately comfortable and the bathroom was so nice it was definitely the sink for me it was fancy everything was just comfortable neighborhood was quiet but most of all the host’s was very polite and they responded quickly anytime we had questions and checkout was at 10 i think and time flies up there so they gave us a later checkout over all I will definitely be coming back because you can’t really beat the price nor can you always find people who are respectful and nice to their guests and I would suggest anyone who is thinking about booking this place to book it because you won’t regret it the food was amazing everything was walking distance like it was lit I didn’t wanna leave…book it!!

Bayou Bonfouca Bungalow, Waterfront by Palmettos
Loved the place. Literally a few feet from the Bayou. Very quiet & peaceful and was perfect for my month-long business trip. Cynthia is great!

Top Floor 2BR-2BA Beachfront Condo - No Owner Fees
The condo was spacious and well appointed with everything we needed. It was a quiet, peaceful location! Great early morning beach walks and awesome saltwater pool.
Quick stats about vacation rentals that are family-friendly in Picayune
Total rentals
20 properties
Nightly prices starting at
$111 CAD before taxes and fees
Total number of reviews
520 reviews
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Wifi availability
20 properties include access to wifi
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- St. Louis Cemetery No. 1
- Biloxi Beach
- Tulane University
- Smoothie King Center
- Get Wet
- The National WWII Museum
- Saenger Theatre
- Mardi Gras World
- Fontainebleau State Park
- Fallen Oak Golf
- Mississippi Aquarium
- Gulf Island National Seashore
- English Turn Golf & Country Club
- Buccaneer State Park
- Crescent Park
- Louis Armstrong Park
- Steamboat Natchez
- Milićević Family Vineyards
- Money Hill Golf & Country Club
- Harrison County Sand Beach
- The Beach
- Grand Bear Golf Club
- Backstreet Cultural Museum
- Ogden Museum of Southern Art