Vacation rentals in Panama City

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Top-rated vacation rentals in Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favourite

Condo in Panama

4.99 out of 5 average rating, 206 reviews

Patty’s Cozy & Quiet Studio with K-bed in Casco

*TOTALLY renovated on NOV 15th 2023: new floors, modern bathroom, new design & art work* Photos to come! Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen beside from the main living space. It is spacious, comfortable and tastefully decorated!

Oct. 9 – 16

$144 CAD per night

Guest favourite

Apartment in Panamá

5.0 out of 5 average rating, 28 reviews

Amazing experience in Casco Viejo with ocean views

Disfruta la cultura panameña desde el centro de Casco Viejo, donde conocerás la arquitectura colonial, podrás visitar los mejores restaurantes, sitios nocturnos y rooftops característicos de la zona. Apartamento tranquilo y confortable. Cuenta con una cama queen, 1.5 baños, armario, aire acondicionado, cocina equipada, comedor, sala, acceso a WiFi de 500 mbps, espacio de trabajo, balcón y comedor al aire libre. ¡Te ofrecemos todo lo que necesitas para vivir la mejor experiencia local!

Aug. 22 – 29

$147 CAD per night

Guest favourite

Townhouse in Panamá

4.97 out of 5 average rating, 162 reviews

Casa Casco Amigos - The Only House in Casco.

Located by the French Embassy in Casco Viejo in the absolute safest and most prestigious area of Panama City, Casa Casco Amigos is a 3 level, 3 bedroom 351 square meter house with a roof terrace and a garden terrace which can sleep 9. Despite the liveliness of the area, there is no noise whatsoever in the bedrooms. Perfect for 1 or 2 families, or a group of 6 to 9 friends who want to be in the heart of the old city, with a sea view and many areas to lounge and avoid the midday heat.

Jul. 11 – 18

$516 CAD per night

Guest favourite

Apartment in Panamá

4.95 out of 5 average rating, 156 reviews

Modern apt ocean view in heart of Panamá yoo tower

Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Jul. 25 – Aug. 1

$249 CAD per night

Guest favourite

Apartment in Panamá

4.97 out of 5 average rating, 131 reviews

Angie’s Place Cozy n Comfy in the ❤️ of #CascoViejo

Remodelado, cómodo y céntrico en el corazón de Casco Viejo, pintoresco lugar declarado Patrimonio de la Humanidad por la UNESCO. Cerca de restaurantes, Bares, Impresionantes Iglesias y Museos. La propiedad data del siglo XVII (1756) historia y buen ambiente. Podrás explorar la zona a pie, cocina full equipada, te sentirás como en casa, rodeado de las famosas paredes de calicanto. -Amplia sala de estar-Smart tv -Cocina full equipada -1.5 baños Policía de turismo 24/7

Sep. 22 – 29

$154 CAD per night

Superhost

Apartment in Panamá

4.82 out of 5 average rating, 136 reviews

Deluxe rooftop with pool Ab4

**Update: Newly renovated with anti-noise windows for a perfect rest** Apartment recently renovated and decorated by an international designer, on the main avenue of Casco Viejo (nocturnal silence area) with views of the church and the most beautiful existing ruins. In addition to a 180º rooftop with an infinity pool. One bedroom apartment with King bed, living room, dining room, kitchen, beautiful bathroom, 55" Smart Tv, private balcony with views of the Church, etc.

Jul. 6 – 13

$144 CAD per night

Guest favourite

Loft in Panamá

4.91 out of 5 average rating, 179 reviews

Amazing Loft with the Best view of Casco viejo!

Hermoso loft ubicado en el centro de Casco Antiguo, la zona más turística de Panamá. Ven, disfruta y relájate en este impresionante loft, con una vista increíble de la Catedral de Panamá. Puedes visitar museos, bares, restaurantes e iglesias ubicados a tan solo unos cuantos metros de distancia. Beatiful Loft located in the center of Casco Antiguo, Panama´s most turistic location. Come, enjoy and relax at this amazing loft, with amazing view to Panama´s Cathedral.

Mar. 18 – 25

$159 CAD per night

Guest favourite

Apartment in Panamá

4.85 out of 5 average rating, 104 reviews

Yoo Panama, comfortable and cozy 54th floor.

Beautiful apartment located on the 54th floor of the most luxurious building in Panama. Areas designed by designer Philip Stark. It has 134 meters, it is fully furnished, it has a bedroom, walk-in closet, a full bathroom, open dining room and kitchen, half bathroom, terrace, laundry room. The building is a unique place, with special and luxurious communal areas; 2 elegant restaurants; 2 pools; Gym; SPA; 2 squash courts; poker sauce, lobby with billa table, etc.

Feb. 18 – 25

$203 CAD per night

Guest favourite

Apartment in Panama City

4.98 out of 5 average rating, 40 reviews

Stunning views from the clouds!

*** Internet 500Mbps Wifi Pro *** *** Netflix, Prime Video, HBOmax, Youtube Premium *** Cozy and spectacular apartment all dressed in white. You will enjoy daily incredible views of the symbols of Panama: the islands, Causeway, Old Town, Canal, Metropolitan park. In this bubble over the bay, you will feel like in the clouds! Place of inspiration and relaxation, strategically located, you will have the whole city at your feet!

Sep. 6 – 13

$252 CAD per night

Guest favourite

Apartment in Panamá

5.0 out of 5 average rating, 40 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a central place where you will find ample gastronomy, fun places, close to bus stations, and the most important shopping center in the city, Multiplaza. This central and quiet apartment is an opportunity that you will not want to miss out on. Offer the perfect combination of comfort, beauty, and convenient location.

Nov. 2 – 9

$113 CAD per night

Guest favourite

Apartment in Panamá

5.0 out of 5 average rating, 20 reviews

Tropicool Loft w/rooftop steps from Casco

This loft is located at the entrance of Casco Viejo where you’re steps from the fish market and all the cool cafés, rooftop bars, and trendy restaurants that make up the neighborhood. Fully equipped kitchen, washer/dryer, 1.5 bath, bedroom on 2nd floor, 2 balconies + communal rooftop, projector w/Netflix, fiber optic internet, and great AC to keep the place cool.

Apr. 18 – 25

$140 CAD per night

Guest favourite

Apartment in Panamá

5.0 out of 5 average rating, 49 reviews

City center apartment with pool and ocean view

You and your family will stay in this relaxed apartment located in the center of the city with great ocean front view and a rooftop pool. The location is convenient for daily life, easy access to various type of restaurants, the commercial area, cinta costera and casco viejo. It is also ideal for people who work remotely.

May 25 – Jun. 1

$132 CAD per night