House vacation rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favourite

Home in Panamá

4.94 out of 5 average rating, 53 reviews

Cozy cabin in the mountains of Cerro Azul

Disfrute de la naturaleza y un clima agradable, alejado del ruido y el calor de la ciudad en esta espaciosa y hermosa cabaña, decorada con detalles de madera que dan una sensación de calidez increíble. En ella encontrará WIFI, TV y Netflix incluido. A solo 50 minutos de la ciudad, es el lugar perfecto para viajar con familia y amigos. Además para familias viajando con niños pequeños, le ofrecemos play y silla de comer. Escríbanos para cualquier duda y estaremos siempre disponible para ayudarle.

Guest favourite

Home in Panamá

5 out of 5 average rating, 10 reviews

Rare oasis of calm & comfort.

Make your trip a memorable one at this unique and family-friendly home. Relax within the comfortable and tastefully decorated living spaces, 4 large en-suite br's & fully equipped kitchen, living room, terrace & garden. Relax in a hammock in the tropical back garden. Watch the sunset from the 360 rooftop terrace. Indulge at Panama's best restaurants within short walking distance. Soak in the exotic bathtub of the master en-suite. Sample delicious flavors from the on-site Kombucha laboratory.

Guest favourite

Home in Panama City

4.91 out of 5 average rating, 44 reviews

Central, comfortable, surrounded by nature|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo, te encantará. Descansar en una hamaca en el balcón y disfrutar de tu casa en la ciudad; lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo; en familia o en grupos de amigos y tu mascota es bienvenida. Una casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. Cercano a Albrook Mall, parque Metropolitano, Casco Antiguo, Coast Way de Amador.

Superhost

Home in Panamá

4.85 out of 5 average rating, 74 reviews

Cozy 3BR Home in Ancon Hill's Lush Oasis

Unwind in a cozy house nestled in Ancon Hill, an urban oasis bordering a nature preserve in Panama City. Perfect for leisure or work trips, relish the close proximity to city treasures such as the captivating Casco Viejo, iconic Panama Canal Miraflores Locks, and the lush Gamboa Rainforest. With Albrook International Airport just 10 minutes away, and Tocumen International Airport 35 minutes, this spot is your seamless gateway to both adventure and productivity.

Guest favourite

Home in Panamá

4.93 out of 5 average rating, 14 reviews

Cantabria House - 10 minutes from the Airport

Welcome to your home in Panama, near the Tocumen International Airport. This comfortable house is conveniently located 200m from the metro station, making it easy to access places of interest in the city. 500mbps wifi connection. The rooms are equipped with Air Condition for your comfort. The kitchen is fully equipped and for your entertainment, enjoy a wide selection of cable television channels. Book now and enjoy an unforgettable stay in Panama!

Guest favourite

Home in Panama City

4.78 out of 5 average rating, 97 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Guest favourite

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 199 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Guest favourite

Home in Panamá

4.93 out of 5 average rating, 14 reviews

Cozy Cabin in Los Altos de Cerro Azul

Relax with all family and friends in this quiet place and very cool weather to stay. Connect all your senses with nature. Panama ⛰️ City Highlands🇵🇦. Enjoy all the greenery around with its viewpoints, waterfall, lake, spas and rivers, not to mention the beautiful hiking trails. In the cabin you can rest, see the pines around, relax in the hammock area, enjoy the sun in cool weather or just sit on the terrace or deck.

Superhost

Home in Panamá

4.86 out of 5 average rating, 29 reviews

Hummingbird House/Casa de Colibri

Hummingbird House Panama is a wheelchair-friendly, serene oasis in Cerro Azul, in the heart of the Chagres National Park, 90 minutes from Panama City and 60 minutes from Tocument Airport. Experience the blend of relaxation and outdoor adventure. This exquisite three-bedroom retreat offers a harmonious fusion of modern comfort, surrounded by natural beauty, ensuring an unforgettable stay for up to six guests

Guest favourite

Home in Panamá

4.94 out of 5 average rating, 34 reviews

Unique 4 room house - direct access to the beach

Incredible newly renovated villa with the best location and views of the entire Old Town. There is no villa that is better located, with the sea at your feet and being able to enjoy the beach. Enjoy the best property in all of Casco Viejo, on the golden mile, on the beachfront. You will enjoy the best sunrises and sunsets, turning the sky completely pink and seeing the Panama Canal.