Lake house vacation rentals in Santee

Find and book unique lake houses on Airbnb

Top-rated lake house rentals in Santee

Guests agree: these lake houses are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Guest favourite
The image features a private dock extending over the calm waters of Lake Marion. The dock is accompanied by wooden seating and surrounded by lush greenery. In the background, a cozy home is nestled among tall trees, providing a peaceful lakeside setting.
Home in Manning
5 out of 5 average rating, 13 reviews

Tie One On! at 4 Bdr Waterfront Lake Marion

Relax, Recharge and "Tie One On" waterfront on Lake Marion! Welcome to your perfect lake escape! This cozy, pet-friendly retreat offers lovely wrap-around peninsular views, waterfront with a small dock, sunrooms, a spacious yard, and all the comforts of home. Enjoy mornings overlooking the water, afternoons kayaking or fishing, and evenings grilling & gazing at tranquil waters. Modern lake living! (Not on "big water" of Lake Marion but on amply sized arm of Lake Marion separated by causeway)

Guest favourite
An outdoor deck features a hot tub, surrounded by trees and comfortable seating arrangements. A gas fire table is located nearby, creating a cozy atmosphere. The picturesque lake view extends beyond the railing, with a vibrant sunset painting the sky in warm hues.
Home in Lake Murray
4.95 out of 5 average rating, 109 reviews

Lake Murray: Panoramic Views, Kayaks & Hot Tub

Welcome to 'Sunshine and Naptime' - This newly renovated home is located on the Chapin side of Lake Murray. The entire house is newly furnished and full of amenities. This 3 bedroom lakefront cottage sits on a point with 180 degree panoramic views. Vaulted rustic pine ceilings showcase the wall to wall windows for a view that will take your breath away. You can watch the sunrise AND sunset from the living room or 600 sq ft deck. There is a hot tub, 2 kayaks, shuffle board & private dock.

Guest favourite
A spacious outdoor area features a sleek in-ground pool surrounded by modern lounge chairs. The chalet showcases a screened porch and an inviting deck with steps leading up to the entry. Lush greenery and a serene landscape create a peaceful environment.
Home in Manning
4.91 out of 5 average rating, 116 reviews

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach

Bring the whole family to this gorgeous lakefront chalet with tons of guest amenities in a quiet neighborhood on Wyboo Creek. Sleeps 2 families comfortably w/ 4 large BR, 2 bathrooms, a game room, a fully equipped kitchen, living area, & screened porch. Enjoy the in ground pool w/ tanning ledge, hot tub, built-in fire pit, outdoor grilling & dining area, private sandy beach, & pier on open water. Launch your boat at the public ramp at the end of the street (.2 miles) & dock at the private pier.

Guest favourite
A vibrant garden filled with blooming orange and yellow flowers creates a colorful border. Green grass stretches out toward a marina, where boats are docked. Sunlight filters through trees, casting light and shadows on the yard, which features picnic tables and recreational seating.
Home in Lake Murray
4.87 out of 5 average rating, 176 reviews

Lake Murray Paradise~2 BR, 1 Bth, Kit/Living area.

Enjoy the full lake adventure with 4 kayaks included. Our property is a lake front paradise w/ about 1 acre on Lake Murray near the dam on the Lexington side of the lake. Close to Columbia, USC and Ft. Jackson. 3 Decks, 1 dock, hot tub & fire pit w/ wood. Private upper deck to the 2 Bedroom, 1 Bath suite with Open Kitchen, Living & Game Area w/ large flat screen TVs, Pool, Ping Pong & Foosball table. The entire upstairs is your private area w/ views of the lake. We offer boat tours. Fees apply.

Guest favourite
A fire pit surrounded by several dark chairs is set on a grassy area by the water's edge. The calm lake reflects the trees and distant docks, creating a serene lakeside environment. A few boats can be seen anchored along the shore.
Home in Ridgeway
4.95 out of 5 average rating, 129 reviews

Hillside Haven on Lake Wateree- Entire House

Lake Wateree rental with 3 bedrooms, 2 bathrooms that will comfortably sleep 8 guests. It also has 2 sleeper sofas. It is located in Ridgeway, SC and less than 5 minutes to Buck Hill Landing. Upstairs, you will find a fully stocked kitchen, living\dining room and master bedroom. Downstairs, there is a second living area with second kitchen, bathroom and 2 bedrooms. Home includes private deep water dock. Perfect location for swimming, kayaking and fishing. Fire pit is perfect for cool nights.

Guest favourite
A serene view of Lake Marion at sunset, with vibrant hues reflecting on the water. A wooden dock extends into the lake, surrounded by lush greenery. The soft contours of the shoreline are visible, creating a peaceful natural setting.
Home in Santee
4.91 out of 5 average rating, 64 reviews

Lakefront Lookout

The best panoramic views of Lake Marion! Whether you're out on the porch or indoors in our air-conditioned unit, you will not miss out on the beauty of the lake. Our updated kitchen and two full bathrooms are stocked with all the essentials. Hop on a boat, swim in the community pool, fish, walk, run, or bike the pedestrian bridge, or just hang out with your company while watching the boats go by. Please respect the fact that there is a small pet fee and we’re alerted when pets are present.

Guest favourite
A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.
Home in Santee
4.96 out of 5 average rating, 168 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Top guest favourite
An aerial view captures the lakeside property surrounded by lush greenery and mature trees. The mobile home sits adjacent to the water, featuring a landscaped yard and access to a private boat launch. Nearby structures and pathways are also visible.
Home in Cross
5 out of 5 average rating, 33 reviews

Fish Haven

Looking for a quiet, yet charming lakeside property? Look no further! Come enjoy this three-bedroom home with direct access to the diversion canal and a private boat launch. Great space for fisherman, families or couples. Ample space for your boat and hitch. Enjoy your days fishing, savor your afternoon by having a beverage and grilling out on the back patio. Spend the evenings playing cornhole and relaxing by the fire pit. It is the perfect setting to create wonderful memories!

Guest favourite
The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.
Home in Summerton
4.83 out of 5 average rating, 110 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Guest favourite
The exterior of the home features a modern architectural design with large windows and a spacious deck. An inviting infinity pool is illuminated, reflecting the colorful sunset. A comfortable outdoor seating area surrounds a fire pit, creating a serene lakeside atmosphere.
Home in Summerton
4.92 out of 5 average rating, 122 reviews

Ultimate Lake Marion Dream Home W/Pool & Swim Spa

Welcome to The White House—a stunning lakefront retreat on Lake Marion. This luxurious home features 4 spacious bedrooms, 3.5 baths, a chef’s kitchen, private dock, gas grill, and HDTVs throughout. Relax in the infinity pool or unwind in the swim spa as you take in the tranquil views. The master suite is a true sanctuary, offering unmatched comfort and elegance. Hosted by Lake Marion Luxury Vacations, this home is your gateway to peace, luxury, and unforgettable memories.

Guest favourite
A spacious outdoor area features a large grassy lawn, a swimming pool, and an enclosed porch. A shaded pavilion with seating stands nearby. The home showcases a blend of modern design and natural surroundings, creating an inviting setting for relaxation and outdoor activities.
Home in Summerton
4.94 out of 5 average rating, 18 reviews

Lake House Retreat

Newly renovated home directly on the big waters of Lake Marion with beautiful open water views and direct lake access. Large open concept interior, a brand-new enclosed back porch. Outdoor kitchen & shower and a gorgeous swimming beach. Park your boat or fish from the dock, kayak down the beach and through the cove, or relax on your own private beach for endless hours of summer fun. Huge backyard for outdoor games with a pool and spa. It's a perfect retreat!

Top guest favourite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 122 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Popular amenities for Santee lake house rentals