
House vacation rentals in Seneca
Find and book unique houses on Airbnb
Top-rated house rentals in Seneca
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Seneca house rentals
House rentals with a pool

Your Lakeside Family & Dog Retreat Awaits!

Hartwell Hideaway

Lake Hartwell: Private Pool, Dock, Pets, Fire Pit

Lake Keowee Access-Dock-Pool-Grill-Clemson 17 Min

Keowee Lakeside with pool for 16

Golf view, lake access, 3 pools!

Mountain Laurel Retreat

Historic peaceful 1906 Farmhouse
Weekly house rentals

Keowee Cottage: lakefront home

Pet-Friendly 5BR Lake Keowee Getaway

Lakefront Keowee Luxury Cottages 127

Lake Keowee Lakefront Rental ,Kayaks, Dock, pets

No cleaning fee farmhouse lake keowee near Clemson

Forest Getaway 5 mins to Clemson- Private Entrance

Lake House Retreat Near Clemson

Sunrise Ridge
Private house rentals

Family-Friendly Farmhouse

water front 4bedrooms,3baths, pontoon rental

5BR*Lakefront*Games*Luxury*Dock

Modern home near Clemson, Keowee

Lake Home & Treehouse ❤ Seneca Treehouse Project

Keowee’s family house with hot tub, kayaks, & more

Cozy Modern Home Close Clemson

Race Car Addict Pit Stop 3BR 3BA
Quick stats about house rentals in Seneca
Total rentals
30 properties
Nightly prices starting at
$55 CAD before taxes and fees
Total number of reviews
1.5K reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Destinations to explore
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- Gorges State Park
- Black Rock Mountain State Park
- Table Rock State Park
- Helen Tubing & Waterpark
- Mountaintop Golf & Lake Club
- Tugaloo State Park
- Tallulah Gorge State Park
- Bell Mountain
- Don Carter State Park
- Jump Off Rock
- Wade Hampton Golf Club
- Victoria Bryant State Park
- Anna Ruby Falls
- Ski Sapphire Valley
- Old Edwards Club
- Victoria Valley Vineyards
- Funopolis Family Fun Center
- Carl Sandburg Home National Historic Site
- Discovery Island
- Haas Family Golf
- Louing Creek