
Vacation rentals in Panama City
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Panama City
Guests agree: these stays are highly rated for location, cleanliness, and more.

Modern apartment in the heart of Obarrio
This apartment stands out for its privileged location in Obarrio, with a modern and cozy design. Located on the 14th floor, it offers a spectacular view, its decoration in neutral tones conveys serenity. The convenience of having two bathrooms makes it unique. Ideal for travelers looking for peace of mind and functionality. Located a few steps from 50th Street and the iconic El Tornillo building. You're surrounded by casinos, hotels, and restaurants. Safe area for walking and enjoying the city.

The Penthouse Annex
Inspired by Panama's rich history with France and located in one of the oldest watch towers in Panama, this chic apartment combines original features of this historically important building with the elegance and style of Europe. Perfectly situated to indulge in the restaurants, cafes, museums and boutique stores of Casco Viejo, and equipped with everything you expect from a home-from-home base, the annex is the perfect combination of comfort and style for couples and small groups of friends.

Cozy apartment near Casco Viejo
Enjoy a stay in one of the most exclusive areas in the center of Panama, few minutes from Casco Viejo the Cozy Apartment City Center offers free WiFi, air conditioning and stunning views amidst skyscrapers. The apartment has one bedroom with a queen-size bed, a bath and shower, a sofa bed, two smart TV, a fully equipped kitchen, a washer and dryer, and a half bath. On the property there is a work area, a gymnasium, a community pool, and a barbeque area FREE PARKING

Central, comfortable studio with bay view
Enjoy a stay in the Center of Panama City! Small, equipped and comfortable studio on Av. Centro de España with 42nd Street in Bella Vista, ideal for one or two travelers. Steps from the Santo Tomás Metro station. A 5-minute walk from the Cinta Costera going down, Parque Urracá, Supermarket Rey and Riba Smith, Zona Bancaria (Calle 50), Calle Uruguay (restaurant area), 15 minutes by car from the Old Town and more. Enjoy the different amenities we offer you!

Cozy apartment facing the sea.
This place is unique, it has its own style. Its location is strategic, it will be very easy to get there. It is located next to the Cinta Costera, near the metro station, Casco Antiguo, and all the tourist centers that Panama offers you. Come and enjoy this beautiful experience in one of the best buildings in Panama, which offers you tranquility, entertainment, gastronomy, cocktails, Panama's history, breathtaking views, all within the same building. Visit us!

Escape to the Heart of Casco with a Private Balcony
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Beautiful Apartment 3 guests
Moderno, elegante y cómodo departamento, cerca de todo! Restaurantes, farmacias, supermercados, canchas de padle, a pocos minutos del centro comercial Multiplaza. Totalmente amoblado, 1 recamara, 1 baño completo, walking closet, cocina, sala, área de desayunador, lavadora-secadora y balcón. Para su disfrute, piscina de agua salada en el último piso, gimnasio, espacio de co-working, incluye un espacio de estacionamiento con valet parking.

Luxury apartment in downtown Panama, banking area
We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

King Bed, Creative Design Steps from Casco Viejo
Casco 114 is a stay created by travelers, for travelers. Located in the heart of Santa Ana, the creative district of Panama’s Casco viejo, it offers a king bed, full-size trundle, sofa bed, private terrace, washer/dryer, and unique decor. At PH Casco View: enjoy a saltwater pool, coworking space, stunning views of both the Old Town and the modern city, paid parking, and all the comforts for an unforgettable stay.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Patty’s Cozy Studio with K bed in Casco Viejo
Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen aside from the main living space. It is spacious, comfortable and tastefully decorated!

Jacuzzi in colonial ruins in beautiful apartment
Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.
Popular amenities for Panama City vacation rentals
Other great vacation rentals in Panama City

New Modern Condo 1BR Best Location! Rooftop Pool

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO

Ocean View Studio Queen bed & pool

Apartment with home warmth Yoo & Arts Panama

Luxury apt in Panama City 2 Rooms 3 Baths

Tropicool Loft w/rooftop steps from Casco

k*| Delightful 1 BR w/King Bed in Calle 50

Luxury Mid-Century Apartment In Casco Viejo
Quick stats about vacation rentals in Panama City

Total vacation rentals
Explore 4,740 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at $14 CAD per night before taxes and fees

Verified guest reviews
Over 114,280 verified reviews to help you choose

Family-friendly vacation rentals
1,480 properties offer extra space and kid-friendly amenities

Pet-friendly vacation rentals
Find 1,680 rentals that welcome pets

Vacation rentals with a pool
2,570 properties feature pools

Rentals with dedicated workspaces
2,880 properties have a dedicated workspace

Wifi availability
4,490 of Panama City vacation rentals include wifi access

Popular amenities for guests
Guests love Gym, BBQ grill, and Laptop-friendly workspace across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City’s top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Destinations to explore
- Cartagena Vacation rentals
- San Andrés Vacation rentals
- Puerto Viejo de Talamanca Vacation rentals
- Uvita Vacation rentals
- Boquete Vacation rentals
- Coveñas Vacation rentals
- Playa Blanca Vacation rentals
- Bahía Ballena Vacation rentals
- Ancón Vacation rentals
- Limón Vacation rentals
- David Vacation rentals
- Valle de Antón Vacation rentals
- Rentals with a washer and dryer Panama City
- Pet-friendly rentals Panama City
- Rentals with lake access Panama City
- Rentals with outdoor seating Panama City
- Hostel rentals Panama City
- Fitness-friendly rentals Panama City
- Rentals with a firepit Panama City
- Apartment rentals Panama City
- Beachfront rentals Panama City
- Guesthouse rentals Panama City
- Smoking-friendly rentals Panama City
- Boutique hotel rentals Panama City
- Hotel rentals Panama City
- Serviced apartment rentals Panama City
- Rentals with beach access Panama City
- Rentals with a sauna Panama City
- Loft rentals Panama City
- Rentals with a hot tub Panama City
- Rentals with an EV charger Panama City
- Private suite rentals Panama City
- Rentals with pools Panama City
- Villa rentals Panama City
- Rentals with an accessible height bed Panama City
- Bed and breakfasts Panama City
- Ski-in/ski-out rentals Panama City
- Family-friendly rentals Panama City
- Rentals with a fireplace Panama City
- Rentals with a home theater Panama City
- Rentals with a patio Panama City
- Townhouse rentals Panama City
- Condo rentals Panama City
- Rentals with breakfast Panama City
- Cabin rentals Panama City
- Waterfront rentals Panama City
- House rentals Panama City
- Things to do Panama City
- Food and drink Panama City
- Art and culture Panama City
- Tours Panama City
- Sightseeing Panama City
- Nature and outdoors Panama City
- Sports activities Panama City
- Things to do Panamá Province
- Food and drink Panamá Province
- Nature and outdoors Panamá Province
- Tours Panamá Province
- Sightseeing Panamá Province
- Art and culture Panamá Province
- Sports activities Panamá Province
- Things to do Panama
- Sightseeing Panama
- Food and drink Panama
- Sports activities Panama
- Nature and outdoors Panama
- Entertainment Panama
- Art and culture Panama
- Tours Panama

