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Hotel vacation rentals in Los Santos Province

Find and book unique hotels on Airbnb

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Popular amenities for Los Santos Province hotels

Family-friendly hotels

Guest favourite
Hotel room in Playa Venao
4.74 out of 5 average rating, 23 reviews

Estrella Room - Quiet, budget friendly - queen bed

KiahRating, 5 stars2 weeks ago
I felt right at home here! I really enjoyed how quiet the property was in the room and by the pool. It was far enough away from music that can be loud at night that you can’t hear it. The whole staff are so kind and welcoming. Everything was very clean. I can’t wait to come back!
Guest favourite
Hotel room in Playa Venao
5 out of 5 average rating, 12 reviews

Brisa - Ocean Views, Calm Vibes, King/Twin beds

KristinaRating, 5 stars3 weeks ago
El Sitio exceeded our expectations. The staff are warm, helpful, and professional. We arrived late and the staff were wonderful at checking us in and getting us settled. The suite was beyond the pictures. The hotel is right on the beach, perfect for us as we were surfing. The restaurant on site was equally amazing, exceeded expectations, and reasonably priced. The bar and restaurant staff were fantastic. In the late afternoon each day a dj would spin until after sunset. The only thing we wished was that we could have stayed longer. Whether for a relaxing trip, surf and sun, family, romance or a friends trip, we highly recommend visiting Playa Venao and staying with the folks at El Sitio. It is truly a magical place!
Superhost
Private room in Playa Venao
4.73 out of 5 average rating, 11 reviews

Arena Room - Family Room, Incredible Ocean Views

MiguelRating, 5 stars4 months ago
I have already gone before and I always get a lot of attention. And the clean rooms, great pool on the beach shore. Good attention. Recommended
Superhost
Hotel room in Playa Venao
4.67 out of 5 average rating, 12 reviews

Playa Room - First floor family space, ocean views

OliverRating, 5 stars2 weeks ago
Excellent everything! Recommended full for beach lovers

Hotels with a pool

Superhost
Hotel room in Playa Venao
5 out of 5 average rating, 7 reviews

Olas Room - Quiet, Second Floor w/ Queen bed

NataliRating, 5 stars1 month ago
My friend and I had the best time! Perfect location, walking distance from all the cute cafes and all employees were lovely :) will definitely be going back 😁
Guest favourite
Hotel room in Playa Venao
5 out of 5 average rating, 8 reviews

Palmas Room - Tranquil Space with King Bed

AmandaRating, 5 stars1 month ago
An incredible oasis and perfect location right on the beach and close to all the fun Venao has to offer. We were lucky to get an upgrade to a premium room for my husband’s birthday. The hosts were very attentive and responsive. Would definitely return.
Superhost
Hotel room in Playa Venao
4.92 out of 5 average rating, 12 reviews

Luna Room - Peaceful and Economical, two twin beds

AdrienRating, 5 stars2 months ago
Great place. I had a terrible ending of being drugged and robbed. Regardless, amazing Airbnb host and a good location.
Guest favourite
Hotel room in Playa Venao
5 out of 5 average rating, 8 reviews

Sol Suite - Large room, King bed, Ocean Views

AndrewRating, 5 stars12 months ago
Amazing stay. Great communication. Great view. The one disruption was there’s light construction happening next door. Overall great stay.
Superhost
Hotel room in Playa Venao
5 out of 5 average rating, 5 reviews

Morro Room - Second Floor, Peaceful location

AbsRating, 5 stars1 month ago
Close to everything. Bed and Sheets were of very high quality. For this room not a super view of the pool & beach but that was expected. Accurate description.
Superhost
Hotel room in Playa Venao
4.75 out of 5 average rating, 4 reviews

Oria Room - Quiet and Peaceful Space, King bed

AstrixRating, 5 stars26 months ago
Great place to stay, right on the beach with a beautiful pool.
Superhost
Hotel room in Las Tablas Abajo
4.67 out of 5 average rating, 15 reviews

Yellow Room for 4 at Casa Lassini - Oceanfront!

LeoRating, 5 stars1 week ago
Very well maintained rooms.
Guest favourite
Hotel room in Las Tablas Abajo
4.87 out of 5 average rating, 15 reviews

Green Room for 3 at Casa Lassini - Oceanfront!

ChristineRating, 5 stars3 weeks ago
Katherine and Rob were wonderful hosts
. Very helpful and nice people
. We enjoyed our stay very much

Hotels with a patio

Private room in PocrĂ­
4.63 out of 5 average rating, 8 reviews

Charming SIMBA Room! Casa Wabi Sabi

RobynRating, 5 stars21 months ago
This is a great place to stay in Pedasi! There isn’t much to do in pedasi - was an extremely quiet town. But this place was attached to a restaurant with great food and live music so it was perfect. Highly recommended!
Private room in PedasĂ­
4.64 out of 5 average rating, 28 reviews

Royal Suite - CASA WABI SABI

Frederic MapgenixRating, 5 stars13 months ago
Alexa was very nice and let us do a late checkout! The place was very clean and very well located near the main park. I definitely recommend to stay at Alexa’s place.
Private room in Las Tablas
4.75 out of 5 average rating, 8 reviews

Hotel Villas Don Pablo / Las Tablas Villa No. 1

MaraRating, 5 stars16 months ago
Very nice hostel, very friendly owners and very nice food in the restaurant right next door. Unfortunately a little off the beaten path so you need a taxi or car to get into the city or to the beach.
Superhost
Hotel room in Cambutal
4.9 out of 5 average rating, 10 reviews

Boutique Inn_The Hill 3_Private Entry_Sea View_16+

FernandoRating, 5 stars7 months ago
My room was decorated with excellent taste (the photos are accurate), very confortable and the bed, huge and relaxingly firm. The view over the garden and the sea from inside as well as from its private terrace are one of its best features. The internet connection is fast, which allowed me to work from there and have conf calls without any problem. The kitchen, gravity center of the Hill, is beautiful and perfectly equipped. The common areas are very well designed - as befits the house - and actually make you want to stay there all day. But there's so much to do in Cambutal. On top of hanging out on its black sand beach set against the tropical greenery, there's good surfing spots, hikes in the jungle, swimming in cascade pools...Stephan had very good advice and helped me organize all these activities. I had such a great time there that I extended my stay and would have stayed more if I could.
Superhost
Hotel room in Cambutal
5 out of 5 average rating, 10 reviews

Boutique Inn_The Hill 1_Private Entry_Sea View_16+

OddRating, 5 stars3 weeks ago
I only stayed for 3 days but I had such an amazing time. Without a doubt, I would stay here again. The accommodation is stunning - beautifully designed and an amazing view. Five minute walk to the beach and restaunts with great food. Duy and Stephan made me feel so comfortable. They were honestly the best hosts ever! And their dog and two cats were the chillest!
Top guest favourite
Hotel room in Cambutal
5 out of 5 average rating, 10 reviews

Boutique Inn_The Hill 4_Private Entry_16+

MajaRating, 5 stars3 months ago
I can wholeheartedly recommend Stephan and Duy’s place. The house and surroundings are stunning, and the hosts are warm, friendly and helpful. The only backside of our stay was that we needed to work (which is totally feasible thanks to good WiFi, desk etc). We hope to return soon. Thanks again Stephan and Duy 😊
Hotel room in La Enea
4.7 out of 5 average rating, 33 reviews

2nd floor room for up to 6 people!

MarieRating, 5 stars2 months ago
The cabanas, pool/patio area and attention met our expectations, keep them clean and nice; the owners are very friendly and the restaurant offers delicious food for lunch and dinner. We felt right at home, the treatment is very warm and friendly, they support what you always need. The only observation is that El Puerto Beach is not as cute as other beaches in Panama. We really enjoyed it because we know it and we already know what to expect, it is a beach that we have gone to many times and we love it because it is quiet, with a delicious breeze, it is shallow and safe for the boys. This place is perfect for a quiet getaway to be secluded for a few days but is also very close to Las Tablas or Chitre if you want to visit. We loved it!

Destinations to explore

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