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Vacation rentals in Panama City

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Top-rated vacation rentals in Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favourite
A modern living space features an open kitchen with wooden cabinetry and a dining area. A curved gray sofa is complemented by yellow pillows, positioned next to a round coffee table. Natural light streams through blinds, illuminating the minimalist decor.
Apartment in Panamá
5 out of 5 average rating, 82 reviews

Apartamento Nuevo en calle 50

Disfruta de una experiencia con estilo en este alojamiento céntrico. Con acceso directo a líneas de buses y el Metro. Cerca de sitios turísticos y a pasos de variedad de restaurantes, grocery store, vida nocturna, casinos y a cuadras de la cinta costera, iglesia del Carmen, parque Urraca. El casco antiguo a solo minutos en uber. Cerca de área de compras. Soho Mall, Multi Plaza Mall y Albrook Mall. Relajante Piscina para adultos y niños. Bar y restaurante, coworking, gym. la pasaras genial.

Top guest favourite
A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.
Apartment in Panama City
5 out of 5 average rating, 37 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Guest favourite
The entrance to the building is framed by manicured trees and architectural elements. Large glass doors lead into the space, reflecting warm lighting from chandeliers overhead. A pathway lined with tiles guides the way, creating a welcoming approach.
Apartment in Panamá
5 out of 5 average rating, 22 reviews

Moderno y lujoso apartamento en Cinta Costera

Vive la experiencia del lujoso PH Yoo con vista a la ciudad en este elegante apartamento con cama king y ventanales de piso a techo. Disfruta de amenidades de primer nivel: piscina, gimnasio, cancha de squash, spa y más. Ubicación privilegiada cerca de zonas turísticas, restaurantes, bares y centros comerciales. Dentro del edificio hay opciones gastronómicas con descuentos exclusivos y valet parking gratuito. Espacio moderno, amplio y sofisticado para una escapada inolvidable.

Guest favourite
A modern living area features a large wave mural that enhances the space's vibrant decor. Comfortable seating arrangements include a sleek white sofa and a pair of stylish armchairs. A glass coffee table is centered among the furnishings, with tastefully arranged decorative accents.
Apartment in Panamá
4.93 out of 5 average rating, 262 reviews

Modern apt ocean view in heart of Panamá yoo tower

Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Guest favourite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Apartment in Panamá
4.98 out of 5 average rating, 146 reviews

Escápate al Corazón de Casco con Balcón Privado

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Guest favourite
A modern living area is showcased, featuring a light gray sofa positioned across from a flat-screen TV on a wooden console. Two abstract art pieces adorn the walls. Floor-to-ceiling windows offer views of the city skyline, enhancing natural light in the space.
Condo in Panamá
4.95 out of 5 average rating, 128 reviews

Beautiful Apartment 3 guests

Moderno, elegante y cómodo departamento, cerca de todo! Restaurantes, farmacias, supermercados, canchas de padle, a pocos minutos del centro comercial Multiplaza. Totalmente amoblado, 1 recamara, 1 baño completo, walking closet, cocina, sala, área de desayunador, lavadora-secadora y balcón. Para su disfrute, piscina de agua salada en el último piso, gimnasio, espacio de co-working, incluye un espacio de estacionamiento con valet parking.

Guest favourite
An aerial view showcases a vibrant pool area featuring a flower-patterned design, surrounded by lounge chairs and numerous umbrellas. A hot tub is positioned beside the pool, with the modern building rising in the background, adding a sleek architectural element.
Apartment in Panama City
5 out of 5 average rating, 10 reviews

Luxury apartment in the Panamá city

This apartment perfectly combines comfort, style, and location. You'll love its modern design, impeccable cleanliness, and peaceful atmosphere. It's equipped with everything you need to feel at home and offers a beautiful view. Plus, you'll be in a prime location, close to restaurants, shopping centers, and with easy access to transportation. Ideal for business trips or simply enjoying the city from a comfortable and stylish location.

Top guest favourite
An inviting living area is featured, showcasing a modern grey sofa accented with decorative pillows. A round glass dining table is surrounded by chairs, and artistic wall frames complement the space. Natural light is filtered through elegantly layered window shades.
Apartment in Panamá
4.97 out of 5 average rating, 118 reviews

Apartamento de lujo Panamá centro, área bancaria

Contamos con una ubicación estratégica justo sobre la vía principal de Panamá (Calle 50) Bella Vista, te encontraras ubicado en el corazón del área bancaria. Si vienes por trabajo o vacaciones, este es el lugar ideal, encontrarás todo tipo de restaurantes a los alrededores, comercios, centro comerciales, tendrás la Cinta Costera a tan solo 10 minutos a pie donde podrás pasear o ejercitarte. Diversión y disfrute a pocos pasos

Guest favourite
Apartment in Panamá
4.99 out of 5 average rating, 118 reviews

Apartamento completo en Panama

Este encantador apartamento está ubicado en uno de los mejores barrios de Panamá, San Francisco, un lugar céntrico donde encontrarás amplía gastronomía, lugares de diversión, cerca a estaciones de buses, y al centro comercial más importante de la ciudad, Multiplaza. Este apartamento céntrico y tranquilo es una oportunidad que no querrás dejar pasar. Ofrece la combinación perfecta de comodidad, belleza y ubicación conveniente.

Guest favourite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.93 out of 5 average rating, 129 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favourite
A private terrace features a jacuzzi surrounded by lush greenery against an exposed stone wall. Wooden decking creates a warm ambiance, complemented by two lounge chairs designed for relaxation, offering an inviting outdoor space for guests.
Apartment in Panama City
4.9 out of 5 average rating, 153 reviews

Jacuzzi in colonial ruins in beautiful apartment

Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.

Guest favourite
A modern living space features a light-colored sofa accompanied by a round coffee table. A large television is mounted on a decorative wall behind the sofa. Natural light streams through tall windows dressed with sheer curtains, enhancing the cozy atmosphere.
Apartment in Panamá
4.94 out of 5 average rating, 47 reviews

Elegant apartment with a view & the warmth of home

This apartment with the warmth of home, elegant and comfortable with spectacular views of the city, located in one of the best areas of Panama City, surrounded by places of interest such as restaurants, commerce and the most important banking area of ​​the city, and its proximity to the Iglesia del Carmen metro station provides easy transportation in and out of Panama City.

Popular amenities for Panama City vacation rentals

Quick stats about vacation rentals in Panama City

  • Total rentals

    4.7K properties

  • Nightly prices starting at

    $14 CAD before taxes and fees

  • Total number of reviews

    114K reviews

  • Family-friendly rentals

    1.5K properties are a good fit for families

  • Pet-friendly rentals

    1.7K properties allow pets

  • Rentals with a pool

    2.6K properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City